Medrometikon-Neo: instructions, application, composition, reviews, description

The drug "Metromicon-Neo" is a drug that has antiprotozoal, antibacterial and antifungal effects. Used to treat various gynecological diseases.

Description and form of release

The drug is available in the form of suppositories of white color, and the color may have a yellow tinge. The candles have a cylindrical shape that resembles a small torpedo. On the cut may be a porous rod with a funnel-shaped depression. The main active ingredient is metronidazole, one candle contains 500 mg of this active ingredient, as well as 100 mg of miconazole. Also in the composition of the drug include and auxiliary means, such as semisynthetic glycerides, which are used to achieve a weight of the suppository in 2000 mg. Candles are in contour packs of two blisters in a cardboard bundle. A total of 14 candles can be found in the package.

pharmachologic effect

"Metromicon-Neo" is a drug that has a bactericidal type of action, it is capable of interacting with deoxyribonucleic acid. The main substance biochemically recovers the 5-nitro group, which inhibits the synthesis of nucleic acid, thereby killing the bacteria. This drug shows high activity in relation to the simplest and obligate anaerobic bacteria: Entamoeba, Trichomonas vaginalis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Veillonella spp, Prevotella, Mobiluncus, Gardnerella vaginalis.

The second active substance - miconazole - has an antifungal effect. During the intravaginal application, the agent is active against Candida albicans. Miconazole exerts a fungistatic and fungicidal effect, thereby inhibiting the plasma membranes of fungi and the biosynthesis of the ergosterol membrane. By changing the lipid composition, the active substance causes death of the fungal cell.

Pharmacokinetics

In contrast to oral administration, with intravaginal administration, the bioavailability of metronidazole is 20%. Half-elimination of active substances from the body occurs in 6-10 hours. Approximately 20% of the basic dose is excreted along with the urine in unchanged form. Miconazole during intravaginal administration is slightly absorbed, so it is not detected in the blood plasma.

Indications for use

For the use of the drug "Metromicon-Neo" the instruction defines such indications:

• Trichomonas vaginitis;
• Vaginal candidiasis;
• Bacterial vaginosis;
• Vulvovaginitis;
• Mixed vaginal infections.

Contraindications

This drug has a fairly small amount of contraindications. The virgins, in the first place, can not be taken by Metronikon-Neo. The instruction also highlights other contraindications. For example, it is forbidden to use the drug for women who breastfeed, as well as pregnant women during the first trimester. It is forbidden to apply the drug to girls who have not reached adulthood (who are not 18 years old). Do not take the drug and those patients who are hypersensitive to individual components of this drug.

The drug should be taken with caution to people with hepatic and renal insufficiency, as well as diabetes, porphyria, in violation of microcirculation and impaired hematopoiesis. In the second and third trimester of pregnancy, as well as with diseases of the nervous system, Metronikon-Neo should also be used carefully.

Application of the drug

The drug is injected into the body by intravaginal route. To use, you need to release the suppository using scissors, cutting the film around the contour, and then insert the opened candle as deep as possible into the vagina. In acute vaginitis or bacterial vaginosis, the drug is used throughout the week. Use the drug should be 2 times a day for 1 candle in the morning and in the evening.

During chronic vaginitis "Metromikon-Neo" (suppositories), one suppository should be used for 2 weeks at night. When relapses of vaginitis, when treated with other means or in the absence of positive clinical dynamics of the candle are used 2 times a day. Use suppositories must be 1 piece in the morning and in the evening for two weeks.

Adverse Reactions

Quite different side effects can occur if you use Metronikon-Neo (candles). Instruction for use indicates several side effects. From local reactions, itching, burning and irritation on the mucous membrane of the vagina can occur, and swelling may also occur. With vaginitis, in connection with inflammation of the mucosa, after the first injection of the suppository irritation may increase. Also, increased irritation may occur after the third day of treatment. To clear these symptoms, you must stop treatment.

In addition, there may be symptoms associated with the gastrointestinal tract. It can be constipation or diarrhea, a spasm or abdominal pain, nausea or vomiting, as well as dryness and metallic taste in the mouth.

Concerning the central nervous system, dizziness or headaches, convulsions, psychoemotional and motor disorders are possible. Also, skin reactions (for example, rash, itching, urticaria) are possible.

An overdose of the drug

If you use "Metromicon-Neo" (candles) in the recommended dosage, there should not be an overdose, since the drug has a low absorption. But when using the drug in large doses, symptoms such as abdominal pain, vomiting, nausea, diarrhea are possible. And also dizziness, ataxia, dry mouth, paresthesia, dark urine, convulsions. When using a high dose of the drug for a long time, peripheral neuropathy is possible. To get rid of the symptoms of an overdose, you need symptomatic treatment. If the drug under any circumstances was taken internally, urgent rinsing of the stomach is necessary.

Special instructions

It should be noted that using the drug "Metromicon-Neo", you should refrain from sexual intercourse. To avoid re-infection with the infection, simultaneous therapy of the sexual partner is necessary. When using the drug, and also after a couple of days after stopping the use, it is necessary to exclude the use of ethanol, since it is intolerable.

In case of severe irritation, it is necessary to stop the treatment with Metronikon-Neo. Patients' feedback indicates that irritation occurs relatively frequently, in which case it is necessary to replace the drug. Suppositories should be used intravaginally, the use of any other method is prohibited.

The drug has little effect on the management of vehicles, but if there are any side effects, for example, dizziness, you should avoid working with mechanisms and do not get behind the wheel of cars.

Storage

The drug should be stored in the dark at room temperature. The storage location must be out of the reach of children. Shelf life of the drug is 36 months, after its completion the drug is prohibited.

The cost of "Metronikon-Neo"

The price of this drug depends on several factors, first of all - from the country in which the goods are manufactured and the distance of transportation to individual points of sale. On average, the price ranges from 350 to 550 rubles. The price is considered low, since in one package there are 14 suppositories (for 1 course of treatment).

Opinions of patients about the drug "Metromicon-Neo"

The reviews of many women are only positive. Practically everyone is happy with this drug. This tool though is an analogue of more expensive, but completely justifies itself. The symptoms of vaginal diseases disappear after only 2 days, this is very encouraging for patients.

Many girls warn that using this medication you need to use daily pads, since the candles flow out of the vagina during the day. There were also negative reviews from people who used Metronikon-Neo (candles). The price, according to them, is available to him, but he does not quite cure. They also add that the drug only relieves the symptoms, but does not have any treatment, so the infection is constantly in the body and occasionally occurs again. But it should be noted that such reviews are much less than positive.

In any case, prior to use, consultation with a doctor and an accurate diagnosis are necessary, as with the independent use of the drug, it can not only not act, but also harm the body.