"Pharmadipin" (drops) from what?

Currently, there are many different drugs from hypertension and angina attacks. One of them is also such as "Pharmadipin" (drops) medicine. From what this drug, we will consider further in more detail.

Composition

The active substance in this case is nifedipine (nifedipine). In 1 ml of this solution, it is in a certain amount. Namely, when recalculating by 100%, the dry type substance is 20 mg. Thirty drops are obtained.

"Pharmadipin" (drops), the instruction for the use of which will be discussed below, has in its composition the presence of such auxiliary substances as polyethylene glycol 400 and ethanol 96%.

Pharmacological properties

This drug has a kind of pharmacodynamics. As already mentioned above, "Pharmadipin" (drops) contains the substance nifedipine, which carries out antihypertensive and anti-anginal action. It helps block the entry of calcium ions into cardiomyocytes and into certain smooth muscle cells of peripheral and coronary arteries through the potential-dependent slow corresponding channels of cell membranes. This is an important property. Nifedipine also relaxes the smooth muscles of the vessels, dilates the peripheral and coronary arteries, and eliminates spasms. This reduces blood pressure, OPSS, postnagruzka on the heart and oxygen demand of the myocardium. Also, when taking this drug, certain manifestations are still observed. Namely, there is a slight decrease in myocardial contractility and heart function, and platelet aggregation decreases somewhat .

Pharmacokinetics

In this regard, "Pharmadipin" (droplets), the instruction for use of which is considered in this review, has its own characteristics. With internal reception, it is absorbed well in the digestive tract. Its bioavailability is about 40-60 percent. Especially rapid development of the effect (after 5-10 minutes) is observed when sublingual administration is performed. This is important to know. Usually the greatest effect is manifested after 30-40 minutes. The exercise of food intake does not particularly affect the rate of absorption of this drug. The manifestation of hemodynamic effect will persist for 4-6 hours. Up to 90 percent of nifedipine binds to blood plasma proteins. Metabolized such a drug as "Pharmadipin" (drops), in the liver. The total clearance of nifedipine is from 0.4 to 0.6 l / kg / h. It is excreted from the body mainly in the form of metabolites of the inactive type. The half-life can be from 2 to 4 hours. In elderly people and patients with cirrhosis, the metabolism of nifedipine is significantly slowed down. As a result, they have an indicator of the half-life of this drug may increase by about 2 times. In this case, it is required to reduce the dose and to increase the intervals between the administration of the preparations of this preparation. Nifedipine in the body is not cumulated. Also, in a small amount, it can penetrate the placental and blood-brain barrier. In this case, it is excreted in breast milk.

Indications for use

Assigns "Pharmadipin" (drops) in the following cases:

• When there is an essential and symptomatic arterial hypertension.
• For the treatment and prevention of stenocardia attacks.
• With cardiomyopathy hypertrophic.
• With Raynaud's disease.

Application

Take "Pharmadipin" (drops) sublingually. With a sharp increase in blood pressure (for example, 180 / 100-190 / 110 mm Hg), a single initial dose of this drug for adults as a whole is about 3-5 drops (2-3.35 mg). Older patients are also given a certain dosage. Namely - no more than 3 drops (about 2 mg). Also, this amount can be dripped on a small piece of breadcrumbs or sugar. His patient should keep as long as possible in his mouth. If the result is insufficient, the dosage of this drug is increased gradually to clinical efficacy. In this case, everything depends on an individual approach. At the subsequent manifestations of the increase in blood pressure should be guided precisely to the prescribed dose. There is also one more specific criterion. It lies in the fact that if the blood pressure rose to 190 / 100-220 / 110 mm Hg. The reception of drops of this preparation can be gradually increased to 10-15 (6.7-10 mg). This should take into account the pressure changes in a particular patient. This is important to know.

It is also necessary to take into account the presence of hypersensitivity of some patients to a drug such as "Pharmadipin" (drops), the reviews of which are positive. In such cases, the dosage is selected individually. Begin with 3 drops, and then gradually increase by 2-3 (1.34-2 mg) until the moment when the necessary clinical effect is achieved.

It should be remembered that if the original dose of this medication is exceeded, a sharp decrease in blood pressure may occur!

Side effect

When using a drug such as "Pharmadipin" (drops from pressure), there may be manifestations of nausea, tachycardia, arterial hypotension, "tides" to the face of the blood. In some cases, the occurrence of allergic reactions in the form of edema of the feet, skin rash. Symptoms of weakness, dizziness, headache may also occur.

Contraindications

Admission of a drug such as "Pharmadipin" (droplets) is prohibited if there is an increased sensitivity to its components, cardiogenic shock, severe aortic and mitral stenosis, hypotension, tachycardia, and also during lactation and pregnancy.

Overdose

In this case, some negative symptoms may appear. Namely, an overdose of a drug such as "Pharmadipin" (drops) can be accompanied by the occurrence of heart failure, shock, metabolic acidosis and seizures, a sharp drop in blood pressure. When these symptoms occur, it is necessary to resort to certain urgent measures of care. They consist of washing the stomach, taking activated charcoal, administering calcium chloride and sympathomimetics, symptomatic therapy.

Features of use

"Pharmadipin" (drops from pressure) or a substitute for it should be used only with careful clinical observation of patients with advanced age and patients who have:

- Unstable angina.

- Expressed heart failure.

Hypertrophic cardiomyopathy.

- Acute aortic stenosis.

- Severe pulmonary hypertension.

- Acute disorders of blood circulation of the brain.

- Diabetes.

- Dysfunction of the kidneys and liver.

Dosage of other drugs that are used with nifedipine, should be installed individually. Cardiac glycosides can also be used during the administration of a medication such as "Pharmadipine" (drops), the analogues of which are indicated below in this text.

When taking nifedipine with the simultaneous use of intravenous magnesium sulfate, pregnant women need careful monitoring of blood pressure. This should be done because there is a possibility of lowering blood pressure, which can harm both the mother and the fetus.

Patients with impaired liver function also need to be closely monitored. In severe cases, the dose should be reduced.

Nifedipine is metabolized through the cytochrome system P450 3A4. As a result, drugs that inhibit or induce this enzyme region can change the effect of the "initial passage" or the clearance of the substance. With the concomitant use of nifedipine with medications of this type, you should monitor blood pressure. If necessary, it is necessary to resort to reducing the dosage of such a drug as "Pharmadipin" (drops).

Conducting separate in vitro experiments revealed the existence of a relationship between the use of calcium antagonists, in this case nifedipine, and biochemical reverse changes in spermatozoa, affecting the deterioration of the latter's ability to fertilization.

Taking "Pharmadipin" (drops), you should refrain from activities of a potentially dangerous type, requiring increased attention. Namely, it is not worthwhile to drive vehicles, work with other mechanisms and so on.

Interactions

"Pharmadipin" (drops) has antihypertensive effect. This property contributes to the strengthening of drugs from the category of blockers. That is, "Pharmadipin" (drops) increases the effect of β-adrenoreceptors, diuretics, nitrates, other antihypertensive agents, drugs and beverages containing alcohol, tricyclic antidepressants. In some cases, nifedipine reduces the concentration of quinidine in the blood plasma. But the cancellation of it substantially increases it. Thus, using combined therapy, it is recommended to monitor the level of quinidine concentration in the blood plasma.

"Diltiazem" reduces the clearance of a drug such as "Pharmadipin" (drops). "Fentanyl" significantly increases the manifestation of the hypotensive effect. As a result, before the introduction of this drug (for less than 36 hours), you should stop taking the "Pharmadipin". Joint use of β-blockers with nifedipine may lead to the development of hypotension. "Pharmadipin" (droplets) helps to increase the concentration of theophylline, carbamazepine and digoxin in the blood. "Rifampicin" leads to a weakening of the therapeutic effect of nifedipine, while accelerating the carrying out of its metabolism. "Cimetidine" helps to increase the concentration of "Pharmadipin" in the blood plasma.

Terms and conditions of storage

In this case, there are certain criteria. Store "Pharmadipin" (drops) in a dry place at room temperature. The medicine must be protected from light and inaccessible to children. Storage of this drug is designed for up to 1 year and 6 months. After the vial is opened - 28 days.

Vacation

"Pharmadipin" (drops) is sold exclusively by prescription.

Packaging

In vials of 25 ml or 5 ml. They are enclosed in a pack.

"Pharmadipin" (drops): analogues in Russia

There are many substitutes for this drug. The main ones are:

"Cordypin."

"Nifedipine."

"Adalat."

- "Cordaflex".

- "Corinfar Uno."

- "Cordaflex RD".

- "Fenigidine."

- Osmo-adalat.

"Cordipin retard."

- "Cordyxin xl".

Conclusion

Now you know what a drug like "Pharmadipin" (drops) is, what it helps and what properties it possesses. In any case, before taking this medication, consult a qualified doctor.