Injections "Texamen": instructions for use, analogues

What are the "Texamen" injections for? Instructions for use and indications of this tool will be presented below. Also we will tell you about whether there are contraindications, analogs and side effects of this drug, what is in its composition and so on.

Packaging of the preparation and its composition

What is the composition of the "Texamen" injections? Instruction for use says that the active substance of this medication is tenoxicam. In addition, the preparation contains additional components such as magnesium edetate, trometamol, sodium hydroxide, sodium metabisulphide and mannitol.

The medicine "Texamen" (injections) goes on sale in vials in the form of a lyophilizate with a solvent, placed in a pack of cardboard.

Pharmacological action of the agent

What is the medicine "Texamen" (injections)? The instruction attached to the drug says that it is an analgesic. Its active substance belongs to oxicam. It has antipyretic, anti-inflammatory and analgesic effects.

The main principle of the action of this medication is inhibition of the rate of synthesis of prostaglandins, as well as a slowing of the metabolism of arachidonic acid and inhibition of cyclooxygenase.

The agent under consideration reduces the rate of phagocytosis and the release of histamine, which allows eliminating any inflammatory process in a short period of time. It should also be noted that the drug slows the withdrawal of macro-energetic compounds, reduces the effect of bradykinin on receptors, reduces the permeability of capillaries and stabilizes lysosomal membranes.

Pharmacokinetic properties of the drug

How long is the preparation "Texamen" (injections) absorbed? The instruction states that the active substance of this agent is absorbed in its entirety immediately after the administration of the drug substance.

Biological availability of the drug is 100%. Virtually 99% of the active substance binds to plasma proteins. Metabolism of the drug is carried out through the hepatic system.

The drug comes out of the human body along with urine and bile. It should also be said that tenoxicam well passes through the hematoplacental (during pregnancy) and blood-brain barrier.

The drug "Texamen": indications for use

The "Texamen" injections are prescribed for patients suffering from degenerative diseases of the muscular and bone tissue, which have an inflammatory origin and are accompanied by a pain syndrome:

• gout;
• rheumatoid arthritis;
• Ankylosing spondylitis;
• Osteoarthritis;
• Osteochondrosis.

In what other cases are the injections "Texamen" used? Instruction for use says that such a remedy is often used to quickly relieve the severe pain syndromes that occur with such deviations as:

• Tendonitis;
• Traumatic injuries;
• Myositis;
• Peri-aerate;
• lumbago;
• Lesions of the ligamentous apparatus;
• polyarthritis;
• neuralgia.

Contraindications for use

When can not use the drug "Texamen"? Instruction (injections and tablets have the same contraindications), attached to the medication, contains the following prohibitions to use:

• Lactose intolerance;
• heart failure;
• Individual hypersensitivity to the active substance;
• Coagulation disorders;
• Impaired hearing;
• Aspirin triad in the anamnesis;
• hypertonic disease;
• Pathology of the digestive system (peptic ulcer and gastritis);
• diabetes;
• Diseases of the hepatic system;
• Pathology of the vestibular apparatus.

It should also be noted that the medication in question is not used in pediatric practice.

"Texamen" injections: instructions for use

With a minor pain syndrome, the drug in question is administered only in tablet form. If this method is not possible or if there are problems with the digestive tract, as well as with severe pain, it is recommended to give injections.

According to the instructions, the drug is administered intramuscularly for 1 vial (or 20 mg) every day. In this form, the drug should not be used for more than 5 days.

How to breed "Texamen" (nyxes)? In the bottle with powder should be added a solvent. After this, the preparation must be shaken vigorously (until the medicinal substances are combined).

Use injections in which small particles of powder remain, is prohibited. It is also not recommended to use a medication that changed color or blurred at the time of mixing.

The drug should be injected deep into the muscle. In this case, the medicine will act more efficiently.

Overdose Symptoms

The administration of elevated dosages of the drug may cause the patient to vomit, epigastric pain, stool, drowsiness, or agitation. In severe cases, people develop seizures, gastrointestinal bleeding (when taking tablets) and disorientation.

Adverse Reactions

The drug "Texamen" in injections is transferred by patients relatively well. However, very rarely the patients can display systemic reactions. As for tablets, they quite often cause undesirable phenomena.

• Digestive system: vomiting, heartburn, increased ALT and AST, flatulence, erosive lesions, gastropathy, stomatitis, epigastric pain, anorexia, stool disorders.
• Cardiovascular system and blood system: tachycardia, thrombocytopenia, agranulocytosis, increased blood pressure.
• Nervous system: increased drowsiness, changes in visual and auditory perception, depression, tinnitus, migraine, irritation of the mucous eyes, excessive excitability, dizziness.

It should also be noted that very rarely when using the drug "Texamen" bronchial spasms, allergic responses, Quincke's edema, skin itching, increased urea nitrogen and hyperhidrosis are recorded.

Drug Interactions

Before using this medication, you should always read the attached instructions. According to her, corticosteroids, salicylates and NSAIDs increase the likelihood of ulceration of the walls of the stomach.

This drug potentiates the effect of anticoagulants of indirect effects and derivatives of sulfonylurea. In this case, probenecid increases the excretion of the active substance of the medication (tenoxicam).

It should also be noted that the presented drug lowers the concentration of glycosides in the blood.

Quinolone antibiotics increase convulsive activity, and the effectiveness of "Mifepristone" decreases with the simultaneous administration of tenoxicam.

Potentially, nephrotoxic drugs, diuretics, serotonin receptor antagonists and antiaggregants are strictly contraindicated in the joint use of the "Texamen" medication.

Pregnancy and lactemia

Teratogenic effects of the drug in animal experiments were not detected. There is also no information on the negative effect of the active ingredient on the fetus. However, it must be remembered that tenoxicam penetrates well into the mother's milk. In this regard, this drug is contraindicated during breastfeeding.

The drug "Texamen" (injections): analogues and price

Structural substitutes for this medication are: Tenikam, Tenoktil and Tobitil. As for the analogs (for pharmacological effects), among them, one can especially highlight such drugs as "Meloksikam" and "Movalis".

The price of injections of "Texamen" is quite high. One bottle of medicine costs about 140-170 rubles. Given that the treatment should be carried out for 5 days, the patient is required to give about 600-900 rubles.

Reviews about the drug

Unlike tablets "Texamen", injections are tolerated relatively well by patients. Many people note that such a drug almost never causes local reactions, but only if all the rules of asepsis are observed.

As for the opinions of specialists, they are also positive. Doctors say that the injections of "Texamen" quite quickly cope with the task. They in a short time stop any pain syndromes, including pronounced. In connection with this fact, most specialists prescribe to their patients this particular drug, especially if therapy of inflammatory diseases of the muscular and bone system is required.