"Clonazepam": reviews. "Clonazepam": instructions for use, side effects

"Clonazepam" is an antiepileptic drug that refers to benzodiazepine derivatives. After receiving the drug "Clonazepam" reviews are mostly positive. The drug has miorelaksiruyuschee and hypnotics, and also has a sedative effect.

Composition, form of the drug "Clonazepam"

The drug can be purchased in tablets with different contents of the main component:

• 0.5 mg. In addition to clonazepam, lactose monohydrate is included. The constituents of the tablets are sodium carboxymethyl starch. Tablets "Clonazepam" contain magnesium stearate, gelatin. Auxiliary substances are also talc and potato starch. The color of the tablets is given by the dye E110.

• 2 mg. Among the auxiliary ingredients are polysorbate 80, lactose monohydrate. The drug contains sodium carboxymethyl starch and sodium lauryl sulfate. Additional ingredients are also talc, gelatin. To the auxiliary components belong and other substances - magnesium stearate, rice, potato starch.

Pharmacological action of the drug "Clonazepam"

Clonazepam has a depressing effect on a large number of structures that make up the central nervous system, mainly on those that are related to emotional activity. The action of the drug "Clonazepam" instructions for use, the reviews display as soothing, anti-anxiety and hypnotics (the latter is moderately expressed). The drug helps to reduce the tone of skeletal muscles, prevents the emergence of generalized convulsive seizures. There is a positive effect on the course of epileptic seizures (focal, generalized).

Pharmacokinetics

The drug is almost completely absorbed from the digestive tract, is excreted mainly by the kidneys (metabolites), a small part of it (2%) is excreted unchanged. The half-life takes between 20 and 40 hours. Bioavailability of the ingested drug is 90%, the connection with blood proteins is 85%, the highest concentration is achieved on average 2.5 hours. When treated with clonazepam, its components are absorbed into breast milk.

Indications for use of the drug

Tablets "Clonazepam" are suitable for treating patients of different ages with epilepsy, regardless of its manifestation:

• Seizures are partial (local, focal) of any degree of severity;
• Convulsive conditions (tonic, clonic);
• Seizures are simple secondary generalized;
• Atypical absences (Lennox-Gastaut syndrome);
• Convulsions myoclonic;
• Typical absence;
• Tonic-clonic seizures of primary and secondary severity.

"Clonazepam" is prescribed to lower muscle tone, as a hypnotic and during the treatment of psychomotor crises.

Use of the drug "Clonazepam"

The desired dosage is determined taking into account many factors. At the initial stage of therapy a small dose of "Clonazepam" (0.5 mg) is used, gradually the dosage is changed until the necessary effect is obtained. Do not exceed the permissible dosage. As the reviews show, Clonazepam can not be abruptly abolished, even when the treatment was short-lived. Sharp refusal of the drug threatens the development of an epileptic fit.

Reception for epilepsy:

• Adults. Initial therapy is performed using no more than 1 mg of the drug. The dose calculated for a day is divided into 3 or 4 doses, which should be performed at the same interval. If there is no possibility to consume the drug in equal doses, the largest part of "Clonazepam" is drunk before going to bed. Usually, a sufficient daily dose is in the range of 4 to 8 mg of the drug. The maintenance dose should be no more than 20 mg (achieved within a period of 2-4 weeks of therapy). When an effective daily dose is determined that allows to maintain the normal state of the organism, it is allowed to take it once before bedtime.
• Children (weight not less than 30 kg). As the reviews show, Clonazepam is initially prescribed to children 0.5 mg each to determine its optimal dose.

Reception in case of a syndrome accompanied by paroxysmal fear:

• Adults. First a day, patients are prescribed 1-2 drug intake (0.5 mg at a time). Most patients have a therapeutic dose of 1 mg / day. In a day, you can not consume more than 1 mg of Clonazepam. The reviews, however, show that in some cases doctors can increase the dose to 4 mg. In such cases, the dosage changes gradually (the interval is 3 days, 0.5 mg may be added). When you want to reduce the severity of sleepiness during the day, a dose that is designed to be taken during the day, you can use before bed.
• Children. For patients who are under 18 years of age, the drug may be ineffective and unsafe if a syndrome is detected.

In order to avoid complications, the drug "Clonazepam" is recommended by doctors to be taken strictly according to the recommendations of the specialist who is carrying out the treatment.

Contraindications to the drug "Clonazepam"

Tablets are not used for hypersensitivity to the substances from which they are composed. The drug is contraindicated in such conditions:

• Myasthenia gravis;
• Impaired consciousness;
• Bearing of the child, breast-feeding;
• Glaucoma (closed-angle);
• Breathing disorders of central origin, severe respiratory failure;
• Severe renal and hepatic insufficiency;
• Manifestations of the syndrome of nocturnal apnea;
• Alcohol poisoning;
• Porphyria of acute form.

Side effects of the drug "Clonazepam"

Consider the side effects that can cause Clonazepam. The use of the drug may be accompanied by negative reactions of the body. Perhaps the appearance of apathy, nausea, irritability. With a negative reaction of the body, a person quickly becomes tired, he has a violation of coordination of movements. To reduce the strength of side effects, you must first apply a small dose, gradually increasing until it becomes optimal.

It is known that during the period of treatment with Clonazepam, its use in violation of the recommendations may cause an overdose. In such cases, there is stunning, which can lead to confusion, stupor, which can result in a coma. Other symptoms include vascular collapse, respiratory failure, drowsiness. It is necessary to wash the stomach (effective immediately after the use of tablets), to conduct appropriate therapy. It is important to regularly monitor changes in such indicators as blood pressure, pulse, respiration. In some cases, artificial ventilation is required. There is an antidote - "Flumazenil", but it is not suitable for administration to patients who are treated with "Clonazepam" for a long time.

Do not combine "Clonazepam" and alcohol. Testimonials make sure that this combination can be life threatening. The same applies to all drugs that act on the central nervous system, inhibiting its functioning.

Drug Interactions of Clonazepam

The effect of using the drug is enhanced by narcotic analgesics, anticonvulsants. The same result is observed when it is used together with antidepressants, neuroleptics, barbiturates, also when combined with alcohol and substances that reduce the tone of skeletal muscles. The effectiveness of treatment is reduced when nicotine enters the body.

Cost, reviews about the drug "Clonazepam"

You can buy tablets "Clonazepam" in Moscow for 97-150 rubles. (30 pcs.). The drug is effective for epilepsy, if the recommendations of a doctor are observed. With atonic cramps, there may be enough therapy lasting two months, for such a time it is possible to switch to supportive treatment. Sometimes there are side effects, but mostly only at the initial stage of treatment, often there is weakness.

Judging by the information that the reviews contain, Clonazepam allows you to get rid of the increased muscle tone in about three weeks. Doctors can prescribe medication for anxiety, fear, VSD, which is accompanied by panic attacks. The drug is effective, it acts quickly.

Reviews Clonazepam is depicted as a good tool that performs its task, but can lead to a deterioration of well-being (weakness, fatigue, etc.).