The preparation 'Pantothenate calcium': characteristics and use in medicine

Pantothenic acid (a drug form of "Pantothenate calcium") is part of the vitamin B group. It is an oily, optically active liquid, readily soluble in water, easily decomposed by exposure to high temperatures, acids and alkalis.

Pantothenic acid is found in foods and is synthesized by the intestinal microflora (Escherichia). After absorption, it enters the bloodstream and spreads to all organs and tissues, deposited in the liver, partially in the myocardium, kidneys and skeletal muscles. In the body, acid is mainly associated with proteins and is part of CoA (coenzyme A). Decomposition products of the drug "calcium pantothenate" are excreted from the body with urine and feces. It should be said that the amount of pantothenic acid extracted is always greater than what was ingested with food. This is due to its bacterial synthesis.

Pantothenic acid is an integral part of CoA, which consists of three parts: a residue of thiolamine, pantothenic acid, 3-phospho-5adenosine-5-diphosphate. CoA is a key link in the metabolism, takes part in the functioning of the Krebs cycle, in the biological synthesis and oxidation of carbohydrates, lipids, the formation of glucosamine, acetylcholine, hippuric acid, porphyrins, etc.

Medicinal preparation "Calcium pantothenate" - slightly yellowish or white powder, bitter to taste, odorless, readily soluble in water. Aqueous solutions are thermostable, however, when exposed to acids and alkalis, they quickly break down. Pharmacological agent is available in the form of tablets, powder and solutions in ampoules.

The preparation "Pantothenate calcium" manifests its pharmacological effect after pantothenic acid turns into coenzyme A, which provides beta oxidation, the synthesis of fatty acids, oxidative decarboxylation and the conversion of pyruvic and ketoglutaric acids into acetylcoenzyme. It helps the absorption of glucose in the intestine, increases the level of glycogen in the liver, normalizes the hormonal status of the organism, especially during pregnancy.

With a deficiency of pantothenic acid in the body, the hormonal function of the pituitary, adrenal and pancreas is inhibited. The level of steroid hormones decreases in the adrenal glands, which provide pigmentation of the hair and skin. The disturbance of the metabolism provokes the appearance of dermatitis, depigmentation of the skin. Dystrophic changes in the adrenal and nerve tissues are observed. Also, coordination of movements can be disturbed , kidney, heart, intestine and stomach diseases can become aggravated. The causes of primary hypovitaminosis are an insufficient amount of this vitamin in food, bowel disease, and also prolonged use of antibacterial agents (sulfonamides, antibiotics).

The main clinical signs of a lack of pantothenic acid in the body are depression, fatigue, fatigue, sleep disorders, headaches and muscle pains, nausea, diarrhea, hyperemia of the foot, duodenal ulcer. With a deficiency of this vitamin decreases immunological resistance of the body. Against this background, respiratory diseases often occur.

To regulate metabolic processes very often doctors prescribe the drug "Pantothenate calcium". This medication is taken for polyneuritis, paresthesia, neuralgia, bronchitis, eczema, dermatitis, burns, trophic ulcers, toxicosis of pregnant women, tuberculosis, hypothyroidism, pancreatitis, gastroduodenitis, etc. The medicine "Pantothenate calcium" is well tolerated by the body. With enteral administration, dyspeptic phenomena are possible , with parenteral (intramuscular injection) - soreness.

Overabundance of calcium (hypercalcemia) can occur due to dysfunction of the endocrine glands (parathyroid gland). Hypercalcemia is recorded in elderly people. Clinic of hypercalcemia can manifest itself in the form of general weakness, loss of appetite, sometimes there are convulsions and constipation.