The drug "Aprovel": analog, instruction, indications

п арат «Апровель» назначается обычно людям, страдающим от артериальной гипертензии. "Aprovel" is usually prescribed to people suffering from hypertension. At patients this medicine is considered the best among similar. «Апровель», применение которого показано, конечно же, далеко не всем пациентам, эффективно регулируя артериальное давление, практически не влияет на сердечную деятельность. The fact is that "Aprovel", the application of which is shown, of course, not all patients, effectively regulating blood pressure, practically does not affect cardiac activity. Very often, therefore, it is prescribed to those patients who can not drink hypotensive drugs.

«Апровель» инструкция по применению. From the article presented below, our reader will find out what instruction is provided for Aprovel preparation . этого лекарства также будут рассмотрены по всех подробностях. Analogs of this medication will also be examined in detail.

Structure of the preparation

This product is produced mainly in oval tablets. Also in the market there are solutions of "Aprovel", intended for intravenous infusion. The main active substance of the drug is irbesarton. Also in the composition of the drug include:

• Lactose monohydrate;

• corn starch;

• Croscarmellose sodium;

• silica;

• Poloxamer 188;

• Colloidal water;

• microcrystalline cellulose;

• Magnesium stearate.

The tablets "Aprovel" weigh 150 mg each. You can learn them by engraving - the heart on one side and the figures 2772 on the other. Also on the market sometimes there are tablets "Aprovel" for 300 mg.

pharmachologic effect

рецепторы ангиотензина 2-го типа. Once in the body of the patient, the drug "Aprovel" begins to actively affect the receptors of angiotensin type 2. The latter respond primarily to the contractility of the walls of the vessels. Upon contact with them, the enzyme angiotensin causes a narrowing of the lumen of the arteries. As a result, and lowering blood pressure.

The main feature of the drug "Aprovel", in comparison with similar, is that it does not interact at all with other enzymes. Due to this, the patient taking the drug has no changes in blood. In particular, the plasma does not increase the concentration of calcium and other kinds of other substances that can adversely affect the activity of the cardiovascular system.

Activate this medicine begins about 5-6 hours after it gets into the digestive tract. The hypotensive effect when taking the drug "Aprovel" develops within 7-14 days. Peak, he reaches about 6 weeks after the start of treatment.

Indications

Since this drug is effective, doctors often prescribe the drug "Aprovel" quite often to their patients. Its use is indicated for such diseases as:

• Essential hypertension;

• Nephropathy with type 2 diabetes and arterial hypertension.

In the latter case, "Aprovel" is prescribed by physicians usually as part of complex antihypertensive therapy. The doctors noticed that this medicine is able to positively influence the renal activity of patients with diabetes mellitus.

Drug analogues

Patients' remarks "Aprovel" medicine deserved good. Many believe that today it is the best tool in their group. But unfortunately, you can not always find it in a pharmacy. In the absence of this drug on sale, of course, we have to use its substitutes. If necessary, you can drink instead of the drug "Aprovel" analog:

• Ibertan.

• "Irsar".

• Converium.

• "Firmas".

Sometimes instead of this medicine patients are also assigned the means of "Lozap" or "Valz". Currently available and the generic of this drug "Irbesartan" (with the same composition, but not branded).

Ibertan

аналог «Апровель» 150 мг и 300 мг. This is a fairly effective analogue of "Aprovel" 150 mg and 300 mg. является и рбесартан. The main active substance in it is also ribesartan. Ibertan is produced in tablets of 75, 150 and 300 mg. Pharmacological action on the patient's body, he has exactly the same as "Aprovel". It differs from this medicine "Ibertan" only in that its composition includes other additional substances.

"Irsar" medication

и рбесартан. In the composition of this preparation , ribesartan is also included as the main active substance . Is issued "Irsar" in tablets. When he is admitted to the patient, a special diet is also prescribed (with the restriction of the amount of salt consumed). «Апровель», аналог его «Ирсар» очень хорошо снижает АД. Like "Aprovel", the analog of its "Irsar" very well reduces blood pressure. At the same time, he has practically no influence on the cardiac activity of the patient.

"Firma" and "Converium"

« Апровель». These drugs can also replace the drug " Aprovel". его «Фирмаста», как и «Конвериум», имеет в своем составе иберсартан. The analogue of his "Firmas", like the "Converium", has in its composition ibersartan. в таблетках. Both products are produced in tablets.

Means "Lozap" and "Valz"

Medicines "Firma", "Converium", "Irsar" and "Ibertan" are synonymous with "Aprovel", because they have a similar composition. л з» и «Лозап», по сути, именно его аналоги. Preparations "Va l z" and "Lozap", in fact, it is its analogs. The active substance is different. Валз» выпускается на основе валсартана, а «Лозап» - лозартана калия. " Valz" is produced on the basis of valsartan, and "Lozap" is losartan potassium. However, the pressure of these drugs is also reduced as effectively as "Aprovel".

Manufacturers and prices

французскими фармацевтическими компаниями Sanofi winthrop industrie и Sanofi-Aventis. The medicine "Aprovel" is produced by the French pharmaceutical companies Sanofi winthrop industrie and Sanofi-Aventis. It is worth packing this medicine from 14 tablets of 150 mg in the area of 320-350 rubles. Depending on the supplier. For a packet with the 14th tab. On 300 mg in drugstores usually ask about 450 r.

Sometimes this medicine is sold and in packages of 28 pcs. In this case, its value is 600 r. (For tablets of 150 mg) and 850 r. (300 mg).

Of course, many patients suffering from elevated blood pressure would like to know whether the drug "Aprovel" has analogs Russian. рсар ». Of the substitutes discussed above, only "I rsar " is produced in our country . российской компанией « КанонФарма Продакшн». It is produced by the Russian company " Canon Production". This medicine costs about 100 r. For 22 pieces of 150 mg.

On which firms produce other drugs considered, you can find out from the table below.

Analogues of "Aprovel"

A drug	Manufacturer country	Company name	Cost
Ibertan	Poland	POLPHARMA SA	202 p.
Converium	Cyprus	"Medekemi LTD"	315 r.
"Firmas"	Slovenia	KRKA dd	200-300 rubles.
Lozap	Slovenia	PHARMACEUTICALS	30 tablets of 50 mg - 300 r.
WALZ	Malta	Actavis Group h	90 tablets of 80 mg - 700 p.

«Апровель». These are the companies that produce substitutes for the drug "Aprovel". его, как видите, немногочисленны. Analogues of its Russian , as you can see, are few. The best of them is Irsar. However, the cost of foreign substitutes for this tool is relatively low.

Contraindications for use

Of course, you can not use "Aprovel" to all patients. You can not use this tool, for example, when:

• Stenosis of the renal artery;

• Hyposalt diet;

• Severe vomiting or diarrhea.

It is also contraindicated to drink these pills for children and adolescents under the age of 18 years. Of course, in no case should you take the drug with increased sensitivity to any of its components.

In addition, the "Aprovel" is contraindicated and is worn by a woman who is carrying a baby or breast-feeding. Stop taking it should be already in the planning of pregnancy. The analogues of the medicine considered above have the same contraindication. «Апровель». But there is today one and the one that is an exception to this rule is the substitute "Aprovel". этого лекарства «Лозап» принимать при беременности допускается. Analogue of this medicine "Lozap" to take during pregnancy is allowed. However, it should be done with great care. And of course, in no case can you assign it yourself to yourself. Drink "Lopaz" pregnant women should be under the strict supervision of the therapist and gynecologist.

special instructions

Do not prescribe the drug "Aprovel" doctors to patients, among other things, and in violation of the water-electrolyte balance. Before starting the use of the medication, all such problems must be corrected using other medications.

If the drug is prescribed to a patient with renal insufficiency, the doctor should periodically monitor the level of serum and potassium creatine in his blood. гиперкалиемией. The same goes for people with hyperkalemia.

Treatment of patients suffering from ischemic heart disease or atherosclerosis using this agent or its analogs should be done under strict control of blood pressure.

Aprovel medicine: instructions for use

эти таблетки больным обычно по одной штуке (150 мг) в день. These pills are prescribed to patients usually one piece (150 mg) per day. If necessary, the dosage can be increased to 300 mg. In large quantities, this drug is never prescribed, because it is ineffective. должного эффекта не наступает, пациенту обычно дополнительно назначают какое-нибудь лекарство из группы диуретиков. If, with an increase in the dose to 300 mg, no proper effect occurs, the patient is usually additionally prescribed some medicine from the group of diuretics.

гипонатриемией первоначально чаще всего выписывают не 150 мг препарата, а 75 мг. Patients with dehydration or hyponatremia are most often not prescribed 150 mg of the drug, but 75 mg. Also, with such a dose, elderly patients are usually treated.

Side effects of the drug

Here such here is provided for the drug "Aprovel" instructions for use. Analogues of it are taken approximately according to the same scheme. On cardiac activity, this medicine has virtually no effect. However, drinking it should, of course, only under the supervision of a doctor. In some cases, this medicine has various side effects on the patient's body. For example, the patient may drop too much pressure. In this case, the patient will have symptoms such as:

• weakness;

• nausea and vomiting.

In addition, uncontrolled use of this drug can lead to such serious problems as a violation of liver function (including hepatitis) or kidneys.

Minor dizziness is also something that can happen with a patient using Aprovel. An analogue of it (almost any) usually causes the same effect. Therefore, during treatment with the use of such a tool should be as cautious when driving a car and when performing work that requires increased attention.

Overdose of the drug

If the permissible dosages of Aprovel drug are exceeded, patients may experience symptoms such as:

• tachycardia;

• Bradycardia;

• collapse.

What are the rules to follow the patient

When taking the drug "Aprovel", the analogues and synonyms of which are numerous, the patient should regularly visit the attending physician. Do not change the dosage without consulting a doctor. To replace this medicine with another without consulting a specialist is, of course, also prohibited.

It is desirable to take "Aprovel" tablets at the same time. Of course, you should not drink this medicine if it has passed the expiration date or it was stored incorrectly.

You can drink these tablets before and after meals. On the absorption of them into the blood, the presence or absence of food in the stomach has virtually no effect.

Features of the use of substitutes

Analogues of this drug, considered above, manufactured on the basis of the same substance, instructions for use are similar. But some of them need to be drunk yet a little differently than "Aprovel". An analogue of this medicine "Converium", for example, is recommended to be taken in the morning before meals.

Of course, they have a very different instruction on the use and substitutes for this drug "Lozap" and "Valz" with another active substance. The average daily dose of the first is 50 mg per day. For patients with chronic heart failure, this medication is usually prescribed in an amount not exceeding 12 mg per day. "Valz" is usually taken at 80 mg per day.

With chronic heart failure, this dose is reduced to 40 mg per day.

Which deserved the drug reviews

Patients, like doctors, usually praise the drug "Aprovel" very much. Reviews (its analogues often do not work so effectively) from patients, he deserved the best. For example, many patients believe that he has fewer side effects than the drugs "Lozap" and "Valz". Using this tool, many patients managed to bring the pressure back to normal within a week.

Rules of storage of a medicine

Thus, we have found out what the drug "Aprovel" actually is (instructions for use, reviews, analogues). The medicine is, as you can see, very good. However, it will work effectively, of course, only if properly stored.

Keep the pack with this product only in a dry room. In this case, the temperature in the room should not exceed 30 C. Of course, you need to store tablets so that children can not reach them.