HealthPreparations

Antipsychotic drug "Klopiksol Depot"

Description of pharmacodynamics of the preparation

The drug "Klopiksol Depot" is an antipsychotic drug, which is a thioxanthene derivative and has pronounced neuroleptic and sedative properties. The pharmacological action of this drug is based on the blocking of dopamine receptors of the brain, as well as stimulation of adrenergic and dopaminergic neurotransmission occurring in the nervous system. The maximum concentration of Clopixol Depot is reached thirty-six hours after intramuscular injection, and the equilibrium concentration in about three months.

Features of the composition and dosage form of the release

This antipsychotic agent is available in the form of a yellow oil solution. In this case, as an active active substance, this preparation contains five hundred milligrams of zincopentixol decanoate. The role of auxiliary components are triglycerides.

Basic medical indications for prescribing

Use the drug "Clopixol Depot" instruction advises for the initial treatment of acute psychosis and chronic psychosis, which are at the stage of exacerbation. To treat a variety of manic conditions, the use of this antipsychotic agent is also indicated. In addition, the drug "Clopixol Depot" is actively used as a supportive therapy for paranoid psychoses and schizophrenia. With senile dementia, accompanied by paranoid ideas, and the manic phase of manic-depressive disorders of voluntary adaptation of the psyche, this drug should also be used. In addition, this neuroleptic drug is often prescribed for the therapy of mental retardation, combined with agitation (the strongest emotional excitement associated with fear and anxiety), psychomotor agitation and other behavioral disorders, and confusion.

List of main contraindications to use

Prescribe an antipsychotic drug "Clopixol Depot" is not recommended for individual intolerance to zuclopentixol, acute poisoning with barbiturates, alcohol or opiates. With pheochromocytoma, coma and severe disorders in the hematopoietic system, this remedy should not be similarly used. In addition, the drug "Klopiksol Depot" should not be prescribed during the period of breastfeeding and pregnancy. With great care this medicine is used for cardiovascular diseases, convulsive syndrome, progressive diseases of the kidneys and liver. In the presence of prolactin-dependent tumors, Parkinson's disease and other brainstem lesions, it is also not recommended to use this antipsychotic.

Possible side effects

The use of this drug in a number of individuals can cause drowsiness, general weakness, discomfort, dizziness and tardive dyskinesia. Tachycardia, constipation, dry mouth and urinary retention may also be noted during the use of the drug Klopiksol Depot. The reviews also testify to the risk of developing orthostatic hypotension.

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