"L-thyroxine": instructions for use, reviews

"L-thyroxine" - a synthetic hormone that supports the work of the thyroid gland. The drug, getting into the kidneys and liver, partially turns into triiodothyronine, promotes the development of tissues and their growth, improves metabolism.

Form of release of the drug, its components

The drug is made on the basis of levothyroxine sodium, the dosage of which can be different - 50, 75, 100, 125 and 150 μg. You can buy a package of 25, 50 and 100 tablets. Excipients are dextrin, microcrystalline cellulose, sodium starch glycolate type A, calcium dihydrate hydrophosphate, glycerides partial long chain.

Pharmacodynamics of the drug "L-thyroxine"

As part of the drug is a synthetic levothyroxine, which has the same effect as the natural thyroid hormone, the production of which is carried out mainly by the thyroid gland.

Due to the partial transformation of the drug into the hormone T3 and the distribution in the cells of the body, the development and growth processes, as well as the metabolic processes, are affected.

Substitution of thyroid hormones is the basis of normalization of metabolism. The action of the drug can reduce cholesterol in hypothyroidism.

Pharmacokinetics of the drug "L-thyroxine"

Absorption is not more than 80% after taking an empty stomach of "L-thyroxine". The instructions for use show that the absorption index is determined by the galenic form of the drug. This process takes place mainly in the small intestine. Eating food significantly reduces the absorption of components.

In plasma, the highest level of the main component is reached approximately for three hours. The therapeutic effect develops on the third or fifth day after the first oral administration. The connection with the plasma proteins is almost complete (more than 99%), this is not a covalent interaction, so there is a rapid exchange between the hormones (bound and free), which is constant. Hemoperfusion and hemodialysis does not affect the content of the components of the drug "thyroxine" in the body, the instruction for use informs that this is due to good binding to proteins.

Partial withdrawal of the drug occurs in about seven days, with hypothyroidism this process can take ten days. With hyperthyroidism, partial removal of the drug from the body occurs quickly - for three to four days. Some of the active ingredient accumulates in the liver. Metabolic processes occur mainly in muscles, brain tissues, liver and kidneys, resulting in the formation of metabolites that are present in feces and urine.

Indications for the use of the drug "L-thyroxine"

Indications depend on the amount of active substance in the composition of the drug.

For tablets "Thyroxin 50" and "Thyroxin 100" the instruction for use displays such indications:

• Hypothyroidism (replacement therapy);
• Thyroid disease of a benign nature;
• Hyperthyroidism (the drug is used in the implementation of thyreostatic therapy as an auxiliary, when a functional euthyroid state is reached);
• Goiter (the medicine is used for preventive purposes, so that there is no relapse of such a pathology as goitre after its resection).

For a drug with a master substance content of 100 μg, additional indications are as follows:

• Implementation of a diagnostic test;
• Cancer thyroid (carry out substitution and suppressive therapy, in most cases after thyroidectomy).

With other doses of the active substance "L-thyroxine", the instruction for use recommends the appointment in the following cases:

• Goiter euthyroid;
• Hypothyroidism;
• A tumor of the thyroid gland of a malignant nature (the drug is used for the purpose of substitution therapy or thyostatic therapy, usually as a result of thyroidectomy);
• Necessity to exclude relapse of goiter.

Contraindications to taking the drug "L-thyroxine"

Medication is not prescribed for hypersensitivity to the substance on which it is made, or to its auxiliary components. There are other contraindications for taking the drug "thyroxine" (tablets). Instructions for use include:

• Manifested acute myocardial infarction;
• Thyrotoxicosis;
• IHD;
• Acute pancarditis;
• Deficiency of decompensated pituitary gland or adrenal cortex;
• Acute myocarditis;
• Hyperthyroidism is decompensated of different origins.

Pregnant women should not use "L-thyroxine" along with thyreostatic drugs - to combine such drugs is unacceptable.

Treatment with "Levothyroxine", dosing of the drug

The instructions indicate recommended dosages of the drug, the doctor should determine the necessary dose. First, a specialist appoints a low dose of the drug and gradually increases it, observing the interval of 14-28 days, until a therapeutic effect is obtained. The tablet is swallowed with water and not chewed. Take the drug at least half an hour before eating. If you can not drink the pill on time, the next time the drug is drunk, as usual. The dose of the active substance in the described medicine, as already mentioned above, is different.

Taking the drug at a dosage of 50, 100 μg

The treatment schedule depends on the age of the patient.

Adult patients

For prevention purposes, when it is necessary to exclude the risk of repeated development of goiter, and for benign disorders of "L-thyroxine 50", the instructions for use recommend prescribing in an amount of 75 to 200 mcg / day. Patients with hypothyroidism in the appointment of replacement therapy are advised to take from 25 to 50 mcg, and with the appointment of maintenance treatment - from 100 mcg, but not more than 200. Hyperthyroidism, when it is planned to perform concomitant therapy, is treated with a drug in a dose of 50 to 100 mcg. In cancer, when it is required to perform substitution or suppressive therapy, 150 to 300 micrograms per day is taken. To perform the diagnostic test, you must take 200 μg of medicament inside within two weeks before the procedure.

Children who have hypothyroidism (acquired, congenital)

In case of congenital disease, children and infants during the implementation of substitution therapy are first prescribed from 10 μg per kilogram of weight. This amount of medicine "Thyroxin 50" instruction for use recommends use for three months. In the future, the dose is changed after carrying out the necessary studies.

Children whose hypothyroidism is acquired, the drug is prescribed in an amount of 12.5 to 50 mcg for reception before breakfast. Gradually increasing the dose, it is brought to the optimum for the implementation of substitution therapy. Children aged less than three years increase the dose at least 30 minutes before the first day of eating. In 10-15 ml of water, the tablets are dissolved, after which a little more water is added, approximately 5-10 ml. The size of the daily maintenance dose corresponds to 100-150 μg per 1 m ² of body area.

Elderly patients

"L-thyroxin 50" instruction for use by such patients advises to take with caution when the treatment is at the initial stage, especially in the presence of ischemic heart disease, a long-term decrease in thyroid function or its hypo-function of severe form. A minimum daily dose of 12.5 μg is necessary. Increase the dose for a long time, little by little. With maintenance therapy, add 12.5 μg of the drug, adhering to the interval of 14 days. In addition to "thyroxine", patients are prescribed other drugs. Older people need to check the blood for TSH more often. It should be taken into account that a dose that is not optimal will not lead to the necessary correction of the TSH level. The minimum dose is sufficient in the presence of nodal goiter, which is large, and with a low body weight.

Taking the drug with a dose of active substance 75, 125 and 150 μg

Let's consider further the scheme of treatment of children and adults by a preparation "L-thyroxine" depending on concentration in it of an active substance.

Adults

When hypothyroidism is first appointed from 25 mcg of the drug, no more than 50. With this maintenance disease, a dose of 100 mcg to 200 is considered, the increase is made at intervals of 14-28 days by 25-50 mcg. "L-thyroxine Berlin-Chemie" instructions for use if necessary to exclude relapse of goiter recommends use in a dose of 75 mcg to 200. In a goiter of a benign nature and euthyroid status, the recommended dose is the same. If hyperthyroidism is treated with thyrostatics and it is planned to perform concomitant treatment with the use of "thyroxine", it is necessary to adhere to a dose of 50 μg to 100. After thyroidectomy is performed in the presence of a malignant tumor, 150 to 300 μg of agent is needed.

Children aged more than three years

If hypothyroidism is acquired, first take from 12.5 mcg to 50, gradually increasing the dose every two to four weeks, taking into account the results of the tests.

Aged people

"The thyroxine" instructions for use at this age advise to use with caution, starting with a minimum dose of 12.5 mcg. The amount of the drug required for admission is increased slowly.

How long does the treatment with L-thyroxine last?

When hypothyroidism is used, "L-thyroxine-acry" instruction for use recommends constantly. In the course of prevention, aimed at excluding recurrence of goiter, its minimum duration is several months and can be increased up to several years, in some cases with prophylactic pill take all life. Therapy with euthyroid goiter in mild form lasts for six months, but no more than two years, if the required result is not, choose another treatment option. In severe forms of the drug take several months or for several years, sometimes such a need exists throughout life. When a person who has a tumor of a malignant nature has a thyroidectomy, usually the drug should be used for life. If thyrotoxin is used as an auxiliary medicine for hyperthyroidism, the instruction for use advises taking it in the same way as when using tablets during thyreostatic therapy.

Pregnancy, breast-feeding

At this time it is very important to carry out substitution therapy with the use of thyroid hormones, it can not be interrupted. Even with intensive use of the drug, there is no risk to the fetus, however, it is not necessary to exceed the dose recommended by the doctor. In breast milk is very little medicine, so there is no danger.

Since during the gestation of a child in the body the level of estrogen is increased, the need for using the drug "L-thyroxine" also increases. Instructions for use show that when hypothyroidism is necessary to check the state of the thyroid gland both during pregnancy and after the end of this period. In addition, if necessary, you need to adjust the dose of the drug, depending on the needs of the body.

If a pregnant woman uses thyreostatics to treat hyperthyroidism thyroid, their dose should be minimal. Pregnant patients are not given a test associated with suppression of thyroid function.

Losing weight with "L-thyroxine"

To reduce body weight, 1.8 kg of the drug is taken per kilogram of weight. The dose of the remedy may change in some cases. The amount of "Tyroxin" used is recommended for use if the person has heart or vascular disease. In such cases, the dose of the drug per kilogram is 0.9 μg. With obesity, on the contrary, it is increased, it is recommended to apply 2 μg of medicament per kilogram of weight.

At the very beginning, when losing weight, no one should take more than 100 micrograms per day. If the remedy was taken within a week, no negative reactions of the body were noticed, an increase in dosage of up to 300 μg is allowed. Both for treatment and for weight loss, it is forbidden to take a larger amount of "L-thyroxine" medication instructions for use. For weight loss, a drug with 50 μg of active ingredient or 100 is used. When using tablets containing 50 μg of the main ingredient, one tablet is consumed for four days half an hour before breakfast, on the fifth to seventh day - two tablets. In the future, you can take up to four tablets per day, not more. The course is completed after 21 days by gradually reducing the dose of the drug.

At a dose of levothyroxine sodium of 100 mcg until the seventh day, the preparation is administered in the same way as in the previous case. From the eighth day on, three tablets are constantly drunk. The course should last seven weeks. At a normal status of a thyroid gland longer does not recommend to accept "the Thyroxine" the instruction on application. For weight loss, the drug is best used in minimal amounts, so that the risk of harm to health has been reduced. But even under such conditions, the hormonal background may be disrupted. Getting to lose weight, based on the admission of "thyroxine", you must take this risk into account. In addition, it is necessary to adhere to dietary nutrition.

Doctors usually do not approve of the use of drugs for other purposes. It is worth remembering that taking a "thyroxine" in the normal state of the thyroid gland and without consulting a specialist can be dangerous. Still, it is necessary to lose weight in a natural way, with the use of physical loads and diets, and not medicinal preparations.

Side effects of "L-thyroxine"

With the use of 50 and 100 μg of the drug "L-thyroxine" instructions for use in possible side effects include negative manifestations in cardiac activity, in the work of the nervous, digestive and reproductive systems. Possible general disturbance of the body and changes in the subcutaneous tissue, skin. Usually, unwanted reactions in the body occur when the prescribed dose of the drug is not suitable or an overdose has occurred, associated with a sharp increase in the amount of the drug used at the initial stage of therapy.

When symptoms of an overdose of the prescribed dose of medication is reduced or a few days do not take the medicine. It is known about cases of death that occurs suddenly because of a malfunction of the heart. Death came in people who had long been drinking tablets containing large doses of the active substance.

If the negative changes in the body disappeared after the withdrawal of the drug "Thyroxin Berlin-Chemie", the instruction on the application allows to restore the treatment. However, the dose should be selected with caution. If allergic reactions were noticed, the drug is not used anymore.

For the dosages of the active substance 75, 125 and 150 μg there are the following disorders:

• Problems with the menstrual cycle;
• sleep disturbance;
• weakness;
• tachycardia;
• Change in normal body temperature;
• cardiopalmus;
• headache;
• diarrhea;
• Nausea accompanied by vomiting;
• anxiety;
• Convulsive conditions;
• heat;
• Pseudotumor of the brain;
• tremor;
• weight loss;
• Angina pectoris;
• arrhythmia;
• Increased sweating;
• Allergic reactions.

When an overdose comes in the same way as in the previous case.

Special instructions to the drug "L-thyroxine"

Do not connect with the decrease in body weight reception of the drug "L-thyroxine" instructions for use. For weight loss, the drug still, in spite of this, many people use, and some even report good results.

Before taking medication, the presence of contraindications is excluded, its use is possible after normalization of the patient's condition, but not in all cases. Some patients have to check the condition of the thyroid gland more often, if such a need exists, the doctor will inform about it.

If the treatment is terminated prematurely, the symptoms of the disease can return, so you need to complete the entire course. The possibility of combining drugs with other drugs should be consulted by a doctor. If you prohibit the use of "Thyroxine" instructions for use, analogs ("Bagotiroks", "L-Tirok", "Eutiroks", etc.) are considered by a specialist and selected with regard to the patient's condition, indications, contraindications.

Reviews about the drug "L-thyroxine"

The testimonies indicate that "L-thyroxine" helps the thyroid gland to perform its function. Many are satisfied with the price, the effectiveness of the drug. People say that it is convenient to use. The medication normalizes the level of thyroid hormones, allows to eliminate goiter, many patients after treatment with the course notice significant improvements, which is confirmed by the results of the tests. Reviews show that the drug contributes to improvements in hypothyroidism, the presence of goiter and in other cases. The instruction states that when certain conditions are detected and after some operations the medication is taken for life, however, not all people consider safe such therapy based on the use of the drug "L-thyroxine". Instructions for use, reviews show that the drug refers to serious medications and apply it without appropriate indications, for example, for weight loss, it is not necessary. In general, no drugs should not be taken if the purpose with which the medicinal product is used is not indicated in the indications and it was not prescribed by the doctor. Both taking medications by healthy people and taking them with certain problems without consulting a specialist often lead to nothing good. In any case it will be useful to visit a doctor.

The reviews show that in most cases the necessary effect was present after treatment with the drug "Thyroxine". Instructions for use, reviews report that, due to the individual characteristics of each organism, the effect of the use of the medication is not always the same, and the severity of the patient's condition has a considerable influence on the result obtained after the implementation of the therapy. In the responses there is information about side effects, which sometimes happens quite a lot. "Thyroxine" can be taken only after testing, and only if it was prescribed by a doctor. It is important to exclude contraindications, to familiarize yourself in advance with the composition of the drug, the undesirable reactions to which it may lead. You should follow all the recommendations of the doctor and increase the dose gradually, you can not abruptly give up tablets.