The drug "Tizalud": reviews of doctors, instructions for use

What is the drug "Tizalud"? Instructions for use, reviews and features of this medication will be discussed below. Also, you will find out whether there are side effects and prohibitions to use.

Form, medicine package, composition

In what form do you release the drug "Tizalud"? Patients' reviews report that this medication is sold in the form of tablets that can include 4 or 2 mg of an active ingredient such as tizanidine.

In addition to the substance mentioned, the composition of the preparation in question includes such additional elements as anhydrous lactose, sodium carboxymethyl starch, magnesium stearate and microcrystalline cellulose.

Tablets "Tizalud", which are described below, are packed in contour cells, which are placed in cardboard boxes.

Pharmacology of oral administration

What is remarkable about such a drug as "Tizalud"? Instruction, expert reviews indicate that this remedy is a muscle relaxant that exhibits a central effect.

What changes occur in the human body after taking the drug in question? The effect of its active component on alpha2-adrenergic receptors (presynaptic) contributes to the inhibition of the excretion of excitatory amino acids from the intermediate spinal neurons, which ultimately leads to a delayed polysynaptic spread of the impulse in the spinal cord. Due to this mechanism of action, the tone of the patient's muscle tissue is significantly reduced.

Features of the medicine

What other properties are characteristic for the drug "Tizalud"? The reviews claim that, in addition to the muscle relaxant effect, tizanidine has a moderate analgesic effect.

According to the instruction, such tablets are very effective for chronic spasms of spinal and cerebral origin, as well as painful and acute spasms of muscle tissue.

Admission of this medication significantly reduces spasticity of the muscles and clonic convulsions, resulting in reduced counteraction to passive movements, and also increases the likelihood of active action.

Indications for taking medication

At what conditions of the patient is the most effective means such as "Tizalud"? Reviews of the drug indicate that this drug is pretty good and quickly eliminates muscle spasms that are observed in pathologies of the spinal column and are accompanied by pain syndrome. Thus, the agent in question is often prescribed for:

• Spondylosis;
• Hemiplegia;
• Osteochondrosis;
• Syringomyelia;
• Lumbar and cervical syndromes.

Are there any other indications for Tizalud? The responses of specialists say that this remedy is actively used in postoperative time after interventions for intervertebral hernias and osteoarthritis of the hip joint. Also, the pills considered are good for pain and spasticity caused by neurological diseases, including chronic myelopathy, cerebral palsy, degenerative spinal cord changes, central seizures, cerebral circulatory disorders, multiple sclerosis, stroke, trauma of the brain and skull.

Prohibitions on the use of oral medication

What kind of contraindications should patients know before taking Tisalud tablets? Instruction, reviews report that there are not very many prohibitions to use this medication. These include only the following states:

• Hypersensitivity of the patient to tizanidine, as well as other constituent elements of the drug;
• Parallel reception of such drugs as "Ciprofloxacin" and "Fluvoxamine", as well as other potent inhibitors of the isoenzyme CYP1A2.
• Pathology of the liver (difficult to flow);
• Period of gestation;
• Underage age;
• The period of breastfeeding.

Careful prescription of a medicinal product

With caution, the medication should be administered in the following cases:

• With renal insufficiency;
• At the age of more than 65-68 years;
• With bradycardia;
• With arterial hypotension;
• When combined with oral contraceptives.

The drug "Tizalud" (tablets): instructions for use

The doctors' comments tell us that you should take this medication only after an individual consultation with a specialist.

Tablets "Tizalud" is consumed orally (oral), washed down with plain water, regardless of the meal.

The dosage of this medicine depends on the type and course of the disease. According to the instruction, for neurological pathologies that cause painful (spastic) contraction of muscle tissues, treatment is recommended to start with a daily dose of 6 mg, which is divided into three doses. Depending on the nature of the spasm and pain, the next 3-7 days this amount of the drug can be increased by 2-4 mg.

As medical practice shows, the maximum therapeutic effect is observed when taking a daily dose of 12-24 mg. In this case, 36 mg is the maximum allowable daily dosage.

To stop painful spasms of skeletal muscles, tablets "Tizalud", reviews of which are ambiguous, appoint three times a day for 2-4 mg. In especially severe cases, doctors recommend an additional medication at night in the same amount (ie 2-4 mg).

The duration of use of the drug "Tizalud" depends on the dynamics of muscular-tonic and pain manifestations. As a rule, acute pain in the muscles requires careful treatment for 8-20 days. In a chronic pain syndrome, depending on the severity and origin, the patient may need longer-term therapy, which is determined on an individual basis (may last for one year).

Side reactions

Unfortunately, taking this medication can cause a lot of negative reactions from the side of the central nervous system, the digestive tract, the cardiovascular and respiratory system, and others. Among the most frequently manifested side effects are the following:

• Nausea, hepatitis, dizziness, dyspepsia;
• Drowsiness, bradycardia, hallucinations;
• Hepatic insufficiency, sleep disorders, dryness in the oral cavity;
• Insomnia, increased transaminase activity of the liver, muscle weakness, lowering blood pressure;
• Increased fatigue, hypercreatininaemia.

It should also be noted that the abrupt reversal of Tizalud, especially after its combination with antihypertensive drugs and prolonged treatment or the administration of large doses, can easily lead to the development of tachycardia, increased blood pressure, and in some cases, to acute impairment of cerebral circulation .

Overdose with tablets "Tizalud"

With a fairly rough and regular disturbance of the dosing regimen, as well as when taking higher doses of the drug in question, the following conditions are observed in the patient: drowsiness, nausea, vomiting, dizziness, hypotension, anxiety, miosis, coma, respiratory failure.

With such symptoms, the patient needs immediate gastric lavage, as well as intestinal cleaning with an enema. In addition, the victim shows the reception of sorbents, conducting diuresis (forced) and further symptomatic therapy.

Interaction with other medicines

With what drugs are forbidden to take the drug "Tizalud"? The concurrent use of this drug with Fluvoxamine, Ciprofloxacin and other potent inhibitors of the CYP1A2 isoenzyme (including Amiodarone, Mexiletine, Propafenone, Cimetidine, Norfloxacin, Enoxacin, Pefloxacin, Ticlopidine "," Rofecoxib "and oral contraceptives) is not allowed.

Anti-hypertensive medications significantly increase the risk of lowering blood pressure and the development of bradycardia.

Ethanol and sedatives can enhance the hypnotic effects of tizanidine.

Special Information

When performing long-term therapy with Tizalud, doctors need to monitor the patient's liver at least once a month (preferably during the first four months of treatment).

Because of the threat of the emergence of a "withdrawal syndrome" in case of refusal of treatment, the dose of tizanidine should be lowered gradually.

From tablets "Tizalud" it is better to refuse, if the professional activity of the patient is connected with driving of motor transport and carrying out of dangerous or exact works.

Cost, analogues

The cost of the drug in the Russian pharmacies is about 130-175 rubles (for 30 tablets, 2 mg and 4 mg). If required, this medication can be replaced by such means as "Tolperil", "Liorasal", "Midokalm", "Baklosan", "Tolperizon" and others.

The drug "Tizalud": reviews of doctors

Comments of experts on the means under consideration are very controversial. In the negative reports of doctors, very often it is a question of adverse reactions to the drug, which are manifested in patients almost immediately after the application of the first dose. In this case, experts say that the most common negative effects are the following: lowering blood pressure, dizziness, weakness, inhibition and drowsiness.

According to the opinion of doctors, such phenomena are possible only when taking large dosages of the medicine, and also if the patient has any contraindications. In this regard, some experts recommend starting therapy with taking half or even ¼ of the recommended dose. In the future, with the normal tolerability of the drug, you can safely switch to the use of a full dosage.

With regard to positive reviews, most doctors note the high effectiveness of the drug in question, as well as its quick action.