"Fraksiparin": instructions for use, reviews

What is the purpose of such a drug as "Fraksiparin"? Instructions for the use of the drug, its form and its composition will be presented below. Also from the materials of this article you will learn about whether this drug has side effects and contraindications.

Form, packaging, composition

In what kind of packaging does the drug "Fraksiparin" come on sale? Instructions for use indicate that the product is released in a syringe, which, in turn, is placed in a blister and cardboard pack.

A weakly-palpating drug intended for subcutaneous injection is a colorless and clear liquid. It can contain 9500, 5700, 2850, 3800 or 7600 IU of anti-Xa supraparin calcium. In addition, the composition of the drug includes such additional substances as purified water, a solution of calcium hydroxide, hydrochloric acid.

Pharmacological and pharmacokinetic features

What is the drug "Fraksiparin"? The instructions for use, applied to the drug, indicate that this is a very effective antithrombotic and anticoagulant.

The active substance of the drug is low molecular weight heparin. It is obtained by depolymerization and exhibits a rather high ability to bind to plasma proteins. This effect leads to increased inhibition of factor Xa.

After the subcutaneous injection, the maximum anti-Xa activity is observed after about five hours. The drug is absorbed by 88%.

If the medication was administered intravenously, its highest concentration in the blood is observed after about 10 minutes. The elimination half-life is 2 hours.

The drug in the liver is metabolized by depolymerization and desulphation.

Indications for use

Why use the drug "Fraksiparin"? Instructions for use (photo medications you can find in this article) states that such medication is often prescribed in order to prevent thromboembolic complications, including after surgical and orthopedic surgical interventions.

Anticoagulant is recommended for people with a high risk of thrombosis, as well as suffering from respiratory or heart failure in acute type.

Contraindications for use

Under what conditions is not recommended to use the drug "Fraksiparin"? Instruction for use contains the following list of contraindications:

• Damage to organs with bleeding;
• Thrombocytopenia, developed against the background of the use of supraparin in the past;
• The age of a person under 18;
• Bleeding or an increased risk of its development, associated with worsening of hemostasis;
• Kidney failure, especially in severe cases;
• Intracranial hemorrhage;
• Infectious endocarditis in acute form;
• Surgery or trauma on the eyeballs, spinal cord or brain;
• Hypersensitivity of the patient to drug substances.

It should also be said that "Fraksiparin", whose reviews are ambiguous, should be taken with extreme caution in renal or hepatic insufficiency, changes in blood circulation in the retina or choroid, eye hypertension, severe hypertension, diseases with increased Risk of bleeding, peptic ulcers in the past, as well as when combined with other anticoagulants, after surgery and patients with a weight of up to 40 kg.

The drug "Fraksiparin": instructions for use

When IVF medication "Fraksiparin" is prescribed to improve rheological parameters of blood and facilitate implantation.

Use this drug should only be prescribed by a doctor. It must be administered subcutaneously to the abdomen, alternating between the left and right sides. Thus the patient should be in a prone position. In some cases, the medication is injected into the thigh.

How to prick Fraksiparin? The needle must be inserted perpendicular to the crease of the skin, which is formed by the fingers of the free hand. In this case, the guard should be kept during the entire injection. After the injection is done, the injection site should not be rubbed.

What should be the dosage of the drug "Fraksiparin"? 0.3 ml is prescribed in order to prevent thromboembolism in the surgical intervention (2850 anti-XA ME). The medication is administered four hours before the operation, and subsequently - once a day. Treatment can be continued for at least one week or the entire period of risk of increased thrombogenesis (for example, before switching to outpatient monitoring).

Now you know the purpose for which the drug "Fraksiparin" (0.3 ml) can be prescribed.

In addition to the operation, this tool is also actively used to prevent thromboembolism in orthopedics. It is administered subcutaneously to 38 anti-Ha IU per kg of body weight. This dose can be increased by 1.5 times, but only on the fourth day after orthopedic intervention.

For people with a high risk of thrombosis, the drug "Fraksiparin" is administered subcutaneously once a day in an amount calculated depending on the weight of the patient (at less than 70 kg, 3800 anti-Ha IU per day, and more than 5,700 anti-Ha IU).

In the treatment of thromboembolism, anticoagulants in the form of tablets should be administered as soon as possible. Therapy "Fraksiparinom" does not stop until the goal of prothrombin time is reached.

Overdose Symptoms

Now you know how to prick Fraksiparin. It should be noted that when using higher doses of this drug, the patient may experience bleeding of different locations. However, weak bleeding does not require urgent therapy (it is necessary only to lower the dose or postpone the next injection).

As for strong overdoses, protamine sulfate helps neutralize the anticoagulant effect of heparin. Its use is required only in severe cases.

Side effects

What side effects can cause "Fraksiparin"? The patients' reviews say that such a drug promotes the development of bleeding of various localizations, thrombocytopenia, eosinophilia, increased liver enzymes and hypersensitivity. Also, patients may develop small subcutaneous hematomas at the injection site. In these cases, treatment with "Fraksiparin" should be discontinued.

Drug Interactions

The risk of hyperkalemia is significantly increased when the drug is treated with ACE inhibitors, potassium salts, angiotensin receptor blockers, potassium-sparing diuretics, Tacrolimus, heparins, Cyclosporin, NSAIDs and Trimethoprim.

Also it should be said that the combination with acetylsalicylic acid, NSAIDs, indirect anticoagulants, "Dextran" or fibrinolytic mediates the effects of drugs.

Pregnancy and lactation period

Is it possible to take Fraksiparin while pregnant? Instructions for use in pregnancy (reviews on the drug will be presented below) states that calcium supraparin (the active substance of the drug) quite easily penetrates the placenta. Also, this drug component is excreted together with breast milk.

In connection with all of the above, it should be noted that injections of "Fraksiparin" when carrying a child and during breast-feeding are not recommended. However, in some cases, this drug still prescribed to patients.

So how to use the drug "Fraksiparin"? Instructions for use during pregnancy should be developed only by an experienced professional. Thus the woman should be on constant control at the doctor.

Analogues, price

The following drugs are analogues of this drug: "Heparin-Pharmex", "Athenativ", "Enoxsarin", "Wessel Douay F", "Cibor", "Heparin", "Fragmin", "Heparin-Biolek", "Flenox", " Heparin-Darnitsa "," Novoparin "," Heparin-Indar "," Clexane "," Heparin-Novopharm ".

The price of the drug "Fraksiparin" is very high. For 10 syringes (0.3 ml) you will have to pay about 2500 rubles.

Reviews about the drug

The patient's comments about the drug in question are ambiguous. Someone helped this drug very well, but someone complains about his inaction. In addition, there are quite a few reviews that "Fraksiparin" causes a large number of adverse reactions.

Experts do not recommend relying on the opinion of those who have already used this drug. The rationale for prescribing a drug, its effectiveness and the risks associated with it, can be assessed only by an experienced specialist.

It should also be noted that there are no bad reviews about this drug during pregnancy.