The drug "Amoxiclav 1000": instructions for use, analogues, reviews

What is the drug "Amoxiclav"? What helps this tool? The answers to these and other questions you will learn from the materials of this article. We will tell you about how much this medicine costs, in what form it is produced and whether it can be combined with alcohol.

Composition, shape and packaging

The drug "Amoxiclav" (1000 mg) contains in itself such active substances as potassium salt of clavulanic acid and amoxicillin trihydrate. Currently, it is issued in the following forms:

• Tablets, film-coated;
• Powder for the preparation of suspensions;
• Lyophilized powder for injection.

Amoxiclav tablets (1000 mg) are packed in aluminum blisters and cardboard packs, respectively.

Powder for the preparation of the suspension can be purchased in bottles of dark glass. A measuring spoon is also attached to the preparation.

As for the injection form, it is available in bottles of 1.2 and 0.6 g, which are placed in cardboard packs.

Pharmacological features

How does the drug "Amoxiclav" work? Instruction, reviews report that the combination of clavulanic acid and amoxicillin is unique in its kind.

Amoxicillin causes the death of bacteria by binding their surface receptors. However, most microorganisms have learned to destroy this antibiotic substance through the enzyme beta-lactamase. The activity of this enzyme is able to reduce clavulanic acid. Due to this effect, suspension, injection and "Amoxiclav" tablets (1000 mg) are used to treat many infectious diseases.

Properties of the medicament

What are the properties of antibiotics? "Amoxiclav" (1000 mg) kills even those strains of bacteria that have already shown resistance to amoxicillin.

This drug has a pronounced bactericidal and bacteriostatic effect on all types of echinococcus, streptococcus and listeria (except methicillin-resistant strains). Also such gram-negative bacteria such as brucella, Bordetella, Gardnerella, Salmonella, Klebsiella, Proteus, Moraxella, Clostridium, Shigella and others are sensitive to this drug.

Pharmacokinetics

Can I take Amoxiclav (1000 mg) with food? Regardless of food, this medicine is well absorbed from the intestine. Its highest concentration is achieved after 60 minutes. It has a high rate and volume of distribution in the body (in tonsils, lungs, synovial and pleural fluids, fat and muscle tissues, the prostate gland, middle ear and sinuses of the nose).

In the mother's milk, this drug comes in small quantities.

Amoxicillin is partially destroyed in the body, and clavulanic acid is intensively metabolized.

Drug is withdrawn through the kidneys, as well as the lungs and intestines. The half-life period is 90 minutes.

The drug "Amoxiclav": what helps?

This antibiotic is prescribed for the treatment of various infectious diseases:

• Respiratory tract (for example, chronic or acute sinusitis), inflammation of the middle ear, zagrug abscess, tonsilopharyngitis, bronchitis, pneumonia and others;
• Gynecological infections (septic abortion, endometritis, salpingitis, etc.);
• Urinary tract (pyelonephritis, cystitis, urethritis, etc.);
• Infections of bone tissue;
• Infections odontogenic, in which the pathogen enters the human body through cavities in the teeth;
• Sexual infections (gonorrhea, chancroid);
• Infections of connective tissue;
• Inflammation of the biliary tract (eg, cholecystitis, cholangitis);
• Infections of the skin, as well as soft tissues (phlegmon, bites, wound infection).

Contraindications for use

Does it have any contraindications to the use of the antibiotic "Amoxiclav"? Treatment with this agent is not carried out with impaired liver function and jaundice (cholestatic), as well as hypersensitivity to medication substances or to all penicillins.

This drug with extreme caution is prescribed in the presence of allergies to cephalosporins, insufficiency of liver function, pseudomembranous colitis and severe renal dysfunction.

In patients with lymphatic leukemia or mononucleosis, which has been prescribed ampicillin, a rash can appear as erythematous. With this reaction, the antibiotic should be withdrawn.

"Amoxiclav" preparation: doses and methods of application

The drug "Amoxiclav" can be administered to patients in different ways. The method of its application depends on the weight and age of the patient, the state of the liver and kidneys, as well as the severity of the infection.

The best time to use this medication is to start eating. The duration of therapy with this drug is 6-14 days. Use the drug for longer than the specified period is prohibited.

Children under the age of 12 years, the antibiotic prescribed at a rate of 40 mg per kg of weight per day. Adolescents, whose weight is more than 40 kg, the drug is given in the same dosage as the adult.

Adults take pills of 375 mg every eight hours, and a drug of 625 mg every 12. For severe infections, the patient is recommended to take a medication at a dose of 625 mg (every eight hours) or 1000 mg (every 12 hours).

Medics emphasize that the tablets "Amoxiclav" may differ in the number of active ingredients. Therefore, it should be borne in mind that it is forbidden to replace the dose of 625 mg with two doses of 375 mg.

For the therapy of odontogenic infections, the following regimen is used: the drug at a dosage of 375 mg is prescribed every eight hours, and at a dose of 625 mg every 12 hours.

If you want to take the medicine for patients with kidney disease, then necessarily take into account the creatinine content in the urine. People with liver pathologies should be monitored continuously.

How should I give the children "Amoxiclav"? Suspension, the price of which is not very high, is prescribed for babies up to 3 months. The dose of this medication is determined using a measuring spoon or pipette. For each kg of the weight of the child must account for 30 mg of amoxicillin. Take medication twice a day.

For children older than 3 months with an average and mild disease, the drug is prescribed at a rate of 20 mg per kg of weight.

How in case of severe infections do they use "Amoxiclav"? Suspension (the price of the medication will be indicated below) to children is prescribed in the amount of 40 mg per kg of weight. The same dose is used for the treatment of deep infections (for example, inflammation of the middle ear, bronchitis, sinusitis, pneumonia, etc.).

The maximum daily dose of amoxicillin to children is 45 mg / kg, and adults - 6 grams. As for clavulanic acid, it can be taken per day not more than 10 mg / kg for children and 600 mg for adults.

Side effects

As a rule, the drug "Amoxiclav" is transferred well enough. Although in some cases, side effects occur in the elderly and those patients who take the medicine for a long time.

Most often, unwanted reactions occur during or after the completion of therapy. Although sometimes their development is observed and after a few weeks after treatment:

• Diarrhea, flatulence, nausea, glossitis, vomiting, pseudomembranous colitis, dyspepsia, stomatitis discoloration of the tongue, gastritis, enterocolitis;
• Anemia (hemolytic), agranulocytosis, eosinophilia, a decrease in the number of platelets and leukocytes;
• Dizziness, headaches, inadequate behavior, agitation, insomnia, hyperactivity, convulsions;
• An increase in liver test results, an asymptomatic increase in the activity of ASAT, ALP and ALT, as well as the level of bilirubin in the blood;
• Rash, erythema multiforme, urticaria, exfoliative dermatitis, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis ;
• Blood in the urine, interstitial nephritis;
• Candidiasis of the oral cavity, fever, candidal vaginitis (with prolonged use of the drug).

Compatibility with other medicines

It is undesirable to combine "Amoxiclav" and the means of indirect anticoagulants, since this can contribute to an increase in prothrombin time.

This drug increases the toxicity of Metatrexate.

The interaction of allopurinol and "Amoxiclav" causes the risk of occurrence of exanthema.

It is forbidden to prescribe medication together with macrolides or tetracyclines, as well as with sulfonamides due to a decrease in its effectiveness.

You can not combine rifampicin and amoxicillin, since these are antagonistic drugs. Their joint intake weakens the antibacterial effect of both.

Taking this medication reduces the effectiveness of oral contraceptives.

It should also be noted that the drug "Amoxiclav" (1000) and alcohol combined is prohibited because of the possible increase in adverse reactions.

Price, synonyms and analogues

Synonyms for this drug are: "Klavocin", "Augmentin" and "Moxicraft". As for the analogs, they are:

• "Amovicomb",
• "Ecoclave",
• "Arlet",
• «Flemoklav»,
• The Bactocklave,
• Toromentin,
• "Clamosar",
• The Rapiklave,
• "Verklav",
• "Ranklav,"
• "Medoblava",
• The Panklav,
• "Liklave."

How much is the antibiotic "Amoxiclav"? Its price depends on the form of release. Tablets (1000 mg) can be purchased for 480 rubles, suspension - for 280, and lyophilized powder for injection - for 180.

Reviews about the drug

According to patients' reviews, this medication is an effective drug that is used to treat a variety of infectious diseases. When taking medication for the therapy of respiratory ailments, relief comes on the third day.

Also, the drug is actively prescribed for the treatment of genito-urinary infections.

In addition to positive reviews of this antibiotic, patients leave negative messages. According to them, the drug "Amoxiclav" causes many side effects, which manifest themselves in the form of nausea, diarrhea and vomiting.