"Motionium": instruction manual, reviews

Vomiting means the eruption (reflex) of the contents of the stomach through the mouth. Usually this process is preceded by a feeling of nausea, as well as swallowing involuntary movements, increased allocation of tears, saliva and rapid breathing.

Along with the remnants of food, gastric juice, mucus, bile and other impurities, man spews and useful substances. This can cause dehydration and electrolyte imbalance. Therefore, with strong and regular vomiting, it is necessary to take a number of measures that will preserve all minerals and other elements in the human body.

One of the most popular antiemetic drugs is "Motionium." Instructions for use, reviews, properties and contraindications for this medication are indicated below.

Composition of the drug, its form, packaging and description

In what form are the preparations manufactured by Motonium? The instruction informs that this agent is produced in the form of round and white tablets in a shell. Their active ingredient is domperidone. The medicament also includes: lactose, microcrystalline cellulose, glycerol, corn starch, magnesium stearate and low molecular weight povidone. As for the surface shell, it consists of hydroxypropyl methylcellulose and polyethylene glycol 6000.

To buy tablets "Motionium" (from what they are appointed, we will tell below) it is possible in blisters or polymer cans, packed in packs cardboard.

Action medication

How does the "Motion" drug work? Instruction for use indicates that this tool increases the duration of contractions of peristalsis in the duodenum and antrum of the stomach. In addition, it significantly accelerates the emptying of the stomach (with the slowing down of this process), eliminates the feeling of nausea and vomiting, and also increases the tone of the esophageal sphincter (lower).

What else is remarkable about the "Motion" product? The reviews indicate that it contributes to the release of prolactin from the pituitary gland. Its antiemetic effect is due to peripheral or gastrokinetic effects, as well as antagonism to the dopamine receptors located in the chemoreceptor trigger zone.

It should also be noted that domperidone has no effect on the secretion of gastric juice.

Kinetic features

What kind of kinetics is characteristic for such a medicine as "Motion"? Instructions for use asserts that after taking the medication, it is absorbed rather quickly.

This drug has a low bioavailability (about 15%). Its peak concentration in the blood is observed after 60 minutes.

Reduced acidity of gastric juice reduces the absorption of domperidone. It penetrates poorly through the BBB, and therefore its use is very rarely accompanied by side effects.

The "Motionium" medication, the instruction for use of which is presented below, is well distributed among the tissues. However, its concentration in the brain is negligible. The binding of the drug to plasma proteins is 91-92%.

Intensive metabolism drug is exposed in the liver and intestinal walls. The time of its half-elimination is 9 hours, and in case of renal insufficiency (expressed) this period is prolonged.

The medicine is given by the kidneys and through the intestine.

Indications for taking medication tablets

In what cases can a patient be prescribed a drug "Motionium"? The doctors' comments state that this drug is used in a complex of dyspeptic symptoms that are associated with gastric or esophageal reflux, delayed gastric emptying or esophagitis. Thus, the agent in question is used in flatulence, overflow feeling in the epigastric region, abdominal bloating, belching, upper abdominal pain, and heartburn without casting (or, conversely, casting) the contents of the stomach back into the mouth.

What else helps the "Motion" medication? The instructions for use tell us that this drug eliminates the feeling of nausea, prevents the development of organic, infectious and functional vomiting, as well as caused by radiotherapy, eating disorders, drug treatment and dopamine agonists (eg, bromocriptine or levodopa).

Contra-indications for taking medication

This medication is cautiously recommended for people with hepatic or renal insufficiency. In addition, it is not prescribed for gastric or intestinal bleeding, hypersensitivity, perforation of the intestine or stomach, mechanical intestinal obstruction, and in the presence of prolactinoma and at the age of up to five years.

Preparation "Motionium": instructions for use

Take this drug should be inside for 20-35 minutes before meals. The dosage of this drug depends on the patient's condition.

In chronic dyspepsia, children from five years of age are prescribed medication at 2.5 mg / 10 kg of body weight three times a day. In case of acute need this drug is taken before bedtime. As for adults, they are prescribed 10 mg of medication (that is, 1 tablet) three times a day and, if necessary, just before bedtime.

If required, this dosage can be doubled.

In acute and subacute conditions (with nausea and vomiting), adult patients are prescribed 20 mg of medicament (i.e., 2 tablets) four times a day and at bedtime. To children from five years, this remedy is recommended to take 5 mg / 10 kg of body weight three times a day and at bedtime.

Adverse events

The antiemetics considered rarely cause undesirable reactions. There are cases of transient intestinal spasms, as well as extrapyramidal disorders in children and people with increased permeability of the BBB.

In addition, against the background of taking this medication, allergic reactions such as hives and skin rashes may develop. Sometimes this drug causes hyperprolactinemia (galactorrhea and gynecomastia).

An overdose of a drug

What are the symptoms when taking higher doses of the drug in question? Experts say that this drug can provoke drowsiness, extrapyramidal reactions and disorientation, especially in children.

To treat such conditions, the victim is prescribed activated charcoal and antihistamines. If extrapyramidal reactions occur, the patient may be recommended anti-Parkinsonian and anticholinergic agents.

Interaction with other means

Anticholinergic drugs neutralize the action of domperidone.

Sodium bicarbonate, "Cimetidine" and other antisecretory, as well as antacid agents, reduce the bioavailability of the drug in question.

Antibiotics belonging to the macrolide group, antifungal azole drugs, Nefazodone and HIV protease inhibitors increase the concentration of domperidone in the blood.

Use in pregnant and lactating women

The drug "Motionium" can be prescribed in the first trimester of pregnancy, but only for special indications.

In maternal milk, the concentration of domperidone is four times lower than in plasma. Experts do not know whether domperidone in such quantities affects negatively on newborn children. Therefore, when taking pills, breastfeeding should be discontinued.

Special Recommendations

In people with severe renal failure, the half-life of the drug increased from 9 hours to 20. However, the concentration of this drug in the blood is much lower than in healthy people.

In view of the fact that this medication is excreted by the kidneys in small amounts, correction of its single dosage in patients with renal insufficiency is not required. However, when the medication is repeated, its multiplicity should be reduced to two times a day (depends on the degree of insufficiency).

With prolonged medication, patients should be under constant supervision.

Terms of storage and conditions of detention

The medicament in question should be kept in a dry place, protected from light, and also inaccessible to young children. The temperature of its storage should not be above 25 degrees.

Shelf life of this drug is 24 months. Do not take the pill after the expiration of the period indicated on the package.

"Motionium": patient feedback

There are a lot of reviews about the facility in question. Most often they are positive. Consumers say that this drug effectively reduces vomiting and eliminates the feeling of nausea. Moreover, this medication is often used to reduce dyspeptic symptoms.

In addition to high efficiency, the merits of this drug include the lack of serious contraindications and availability. It should also be noted that the drug "Motionium" almost never causes side effects, including in children older than 5 years of age.