Excerdine: analogues. Medication for migraine «Excerdine»: reviews, prices, analogies

Migraines are a disease that can not be tolerated without taking analgesics. The attack can last up to 4 days. A person in this period is unable to work. In doing so, he uses potent drugs to get rid of the throbbing painful pain. But, unfortunately, most of the drugs that can eliminate such discomfort cause addiction and lead to the fact that the ailment acquires a chronic form. Modern pharmacology has developed an excellent new drug. An agent that excellently relieves migraine, restores work ability, but does not cause dependence, is the medicine "Excerdine". Analogs of the drug are no less effective.

a brief description of

Medication for migraine "Excedrine" is a combined drug, belonging to the group of analgesics-antipyretics. It is used for severe headaches. Effective means "Excerdine" from migraine. At the same time, it can even prevent an attack.

Structure of the medicine

The effectiveness of the drug lies in its components. The medicine contains:

• Acetylsalicylic acid;
• caffeine;
• paracetamol.

It is thanks to these elements is a multifaceted impact on the body. As a result, a quick effect is guaranteed, the pain syndrome is completely eliminated.

Paracetamol in the amount of 250 mg, acetylsalicylic acid - 250 mg and caffeine - 65 mg contains one tablet of the medicine "Excerdine". The composition, therefore, in this agent of active substances is very significant. That is why it is recommended to apply the drug with extreme caution. Patients should strictly take into account the dosage and not exceed it.

In addition, this preparation contains auxiliary ingredients:

• Giprolose;
• microcrystalline cellulose;
• Stearic acid.

Effects on the body

Tablets from migraine "Expedrine" are made of three different substances that have different properties. Their combination allows you to get rid of the pain of any nature. Since migraine attacks accompany a sufficiently long and severe discomfort, to get rid of it you need a very strong medicine. This is exactly the drug "Excerdin".

What is its effect and what effect does the given agent have? The answer to the question is the effect on the body of each component contained in the medicine:

1. Paracetamol. The substance has excellent anti-inflammatory and antipyretic properties. It can influence the brain center, which is responsible for controlling the temperature in the hypothalamus. An important role in the removal of migraine is precisely the anti-inflammatory quality, because the elevated temperature does not refer to the symptoms of the disease.
2. Acetylsalicylic acid. The component has pronounced antipyretic properties. It is able to inhibit and eliminate inflammatory processes. This reduces the pain syndrome. Acetylsalicylic acid is able to prevent the occurrence of blood clots. It stops the process of their formation at the cellular level, perfectly improves blood circulation in inflamed areas.
3. Caffeine. The role of this substance for reducing pain is most significant. Acetylsalicylic acid and paracetamol can temporarily eliminate discomfort. Caffeine has a positive effect on blood circulation in the brain and helps to get rid of the causes of pathology. In addition, it excites the respiratory and vasomotor centers, promotes the widening of the narrowed blood vessels, prevents the binding of platelets. Caffeine excels in fatigue and drowsiness. It significantly increases the working capacity of the body and its tone, thereby improving the overall well-being of the patient. The combination of acetylsalicylic acid with this substance can increase blood flow and positively affect the vessels of the brain.

Pathologies in which the drug is used

It is expedient to use tablets "Eksedrin" with pain syndromes of light and medium intensity of the most diverse origin:

• migraine;
• headache;
• neuralgia;
• toothache;
• Myalgia, arthralgia (discomfort in the joints and muscles);
• Algodismenorea (pain during menstruation);
• Febrile syndrome.

Pharmacokinetics of the drug

In most cases, the medicine "Excedrine" is well tolerated by the body. Customer feedback fully confirm this. This effect is due to the components included in it:

1. Paracetamol is perfectly absorbed into the digestive tract. It is metabolized in the liver, and is excreted by the kidneys in the form of sulfate conjugates and glucuronides. Less than 5% of the substance comes out unchanged. With plasma proteins, communication is negligible when using the usual therapeutic dose. But when the latter increases, it increases. Hydroxylated metabolite, formed in small amounts in the liver under the influence of mixed oxidases and usually rendered harmless by binding to glutathione, can accumulate in case of an overdose of paracetamol and cause liver damage.
2. Acetylsalicylic acid is completely and very quickly absorbed. It undergoes hydrolysis in the digestive tract, blood and liver. In this case, salicylates are formed. Later they undergo metabolism in the liver.
3. Caffeine is also rapidly absorbed in full. The maximum concentration in the body is observed during the 5-90 minutes after the use of the drug on an empty stomach. Excretion occurs as a result of hepatic metabolism. The substance is distributed over all body fluids. The connection with plasma proteins reaches 35%. The component is completely metabolized and excreted from the body by the kidneys.

Dosing regimen

It is intended for oral administration of "Excerdine". The medicine is used during or after a meal. It is recommended to drink plenty of water.

A single dose for adults and adolescents (from age 15) is 1 tablet every 4-6 hours. If a person senses signs of an impending migraine, it is recommended to use 2 pills at once. This will prevent an attack of ailment. However, it should be remembered that eating more than 6 pieces per day is strictly prohibited.

Important caveat

An effective medicine is allowed to apply to eliminate pain discomfort for 3 days. During this time the patient should consult with his attending physician, who will choose the perfect alternative remedy, which allows to fight with pathology.

In some cases, the patient is recommended to prolong the use of the drug. But such a decision can only be made by a specialist on the basis of appropriate indications. It is not recommended to use tablets from migraine "Excerdine" independently for more than 3 days. The increase in dose can lead to serious consequences. Such as liver damage due to accumulation of metabolites in the body.

Side effects

Drug use may not have a very positive effect on the body. Since there are a number of side effects, the "Excerdine" means. Analogues of the drug can be recommended by the doctor in charge, if the above-mentioned medicine is not suitable for the patient.

So, the following side effects are possible:

• nausea, vomiting;
• Gastralgia;
• Hepatotoxicity;
• Erosive-ulcerative lesion of the gastrointestinal tract;
• Nephrotoxicity;
• Allergic reactions;
• Increased pressure;
• tachycardia;
• dizziness;
• Bronchospasm;
• headache;
• Visual impairment;
• Lowering of platelet aggregation ;
• noise in ears;
• Hemorrhagic syndrome (bleeding gums, nosebleeds, purpura);
• Exudative erythema malignancy (or Stevens-Johnson syndrome);
• deafness;
• Epidermal toxic necrolysis (or Lyell's syndrome);
• Kidney damage (papillary necrosis possible);
• Development of Raynaud's syndrome in children (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, liver function disorders).

Contraindications to admission

Unfortunately, an effective medicine is not meant for all people. After all, the remedy has a number of contraindications. They must be taken into account before use. But despair, if the medicine does not fit, not worth it. The attending physician will very easily replace the "Excerdine" remedy. Analogues will make it possible to achieve an acceptable result.

Contraindicated in the following pathologies and conditions:

• Hypersensitivity to ingredients;
• Gastrointestinal ulcers in the stage of exacerbation;
• bronchial asthma,
• Gastrointestinal bleeding;
• Recurrent nasal polyposis (paranasal sinuses);
• Intolerance to NSAIDs;
• Surgical interventions that accompany bleeding;
• Hemorrhagic diathesis;
• arterial hypertension;
• hemophilia;
• Hypoprothrombinemia;
• Portal hypertension;
• glaucoma;
• Severe ischemia of the heart;
• Avitaminosis K;
• Lack of glucose-6-phosphate dehydrogenase;
• Kidney failure;
• pregnancy;
• lactation;
• Sleep disorders;
• Increased excitability;
• Children's age (the drug does not apply until 15 years).

An overdose of a medicine

Drug "Excedrine" from migraine should be taken only in the above doses. Since the abuse of the drug can lead to many unpleasant symptoms.

Paracetamol overdose is signaled by the following symptoms:

1. During the first days, skin pallor, vomiting, nausea, abdominal pain, glucose metabolism disorder, anorexia, metabolic acidosis are observed .
2. After 12-48 hours, signs of impaired liver function, expressed by failure with progression of encephalopathy, are possible. With very severe overdoses, coma and death are possible. There may be renal failure accompanied by tubular necrosis, pancreatitis, arrhythmia.

Overdose, provoked by acetylsalicylic acid, gives the following symptoms:

1. At a mild degree - a vomiting, a nausea, a giddiness, disturbance of sight, noise in ears, a headache.
2. When severe poisoning - shortness of breath, cyanosis, choking, sticky cold sweat, respiratory acidosis, respiratory paralysis.

Abuse caused by caffeine is expressed by the following symptoms:

• Gastralgia;
• Excitement, anxiety;
• Confusion;
• Motor anxiety;
• dehydration;
• arrhythmia;
• Frequent urination;
• tachycardia;
• Hyperthermia;
• Increased pain and tactile sensitivity;
• tremor;
• tinnitus;
• Nausea, vomiting (sometimes with the presence of blood);
• Epileptic seizures.

When an overdose of the drug should urgently seek help from doctors. During the first 4 hours it is recommended to wash the stomach, provoke vomiting. It is necessary to use a laxative preparation and "Activated charcoal".

Drug analogues

Remember that any drug should be prescribed by a doctor, since each remedy has its own indications and contraindications.

And only the doctor is able to replace the drug "Exedrine" with another drug. Analogues for the active component are as follows:

• "Aquacitramone".
• "Acifein."
• "Ascofen".
• "Kofitsil plus."
• "Citramarin."
• "Migrenol Extra."
• Citramon.
• Citrapar.

Cost of preparation

For all its effectiveness, the drug "Exedrine" from migraines is inexpensive for consumers. The packaging price (10 tablets) varies between 120-150 rubles. The cost of a drug of 20 pills is 210-250 rubles.

Interaction with other drugs

Patients who use the drug "Excerdine" should understand that it can enhance the impact on the body of other means, such as:

• "Heparin";
• Indirect anticoagulants;
• "Reserpine";
• Hypoglycemic drugs;
• Steroid hormones.

Note that simultaneous use of the "Excerdine" with other NSAIDs may lead to side effects. So, for example, the interaction of the drug with anti-gout, hypotensive drugs, the "Furosemide" means leads to less effectiveness of these groups of drugs.

Consumer opinion

Any drug has (not exception and medicine "Excerdin") reviews both positive and negative.

Some consumers frankly narrate that once they try the medicine once, they do not part with it. Many women wear an effective remedy in their purse. You never know when a painful attack will overtake you. Such patients notice that one tablet is capable of relieving an unpleasant syndrome within an hour. And in the case of severe migraines, the pain of 2 Expression pills eliminates pain. Feedback indicates the excellent effectiveness of this tool.

Other consumers hold a different view, stating the uselessness of the drug. They argue that the active ingredients of the medicine can be purchased separately at a much lower cost in the pharmacy. However, such consumers forget that the product was effective as a result of the correct combination of all components that perfectly complement each other.