"Diocor 160": instructions for use, reviews, analogues. "Diocor solo 160": user manual, reviews

A huge number of people occasionally suffer from increased blood pressure. However, such a pathological condition not only brings tangible discomfort to the patient, but also threatens his life. Therefore, in the modern pharmaceutical market, there are many drugs that contribute to lowering blood pressure.

The most popular among those people who regularly suffer from hypertension, is a medication such as "Dyokor 160". Instructions for use, analogs of this medication, as well as reviews about it, features and properties will be presented below.

Composition, description, packaging and shape

The medicine "Diocor 160", the instruction of which is contained in a cardboard box, is made in the form of tablets. They are film-coated and contain active ingredients such as valsartan and hydrochlorothiazide. Also included in the composition are microcrystalline cellulose, sodium lauryl sulfate, potato starch, talc, corn starch, croscarmellose sodium, magnesium stearate, colloidal anhydrous silicon dioxide and opadry II Orange.

One can not help saying that a drug such as "Diocor Solo 160" can be found on sale. From the previous one, it differs in that its active ingredient is only valsartan.

Principle of action of a medicament

What is Dioxor 160? Instruction for use reports that this antihypertensive agent, which includes a thiazide diuretic and an antagonist of angiotensin II receptors.

This agent has a wide range of physiological effects that take both mediated and direct participation in the regulation of blood pressure. Angiotensin II is a strong vasoconstrictor caused by direct vasopressor action. It also delays sodium and stimulates the secretion of aldosterone.

Valsartan is a specific and active antagonist of angiotensin II receptors. It is designed for oral administration and selectively acts on the receptors of the AT1 subtype, which is responsible for the effects of angiotensin II. Partial agonistic activity in relation to receptors of the AT1 subtype does not manifest this element.

Also, valsartan does not inhibit ACE, which converts angiotensin I into angiotensin II, destroying bradykinin. There are no side effects due to bradykinin.

In people with hypertension, this medication causes a decrease in blood pressure. However, it does not affect the heart rate.

In many patients, after taking a single dose of the drug in question, the onset of antihypertensive activity is observed within 2 hours, and the decrease in blood pressure after 6 hours.

The antihypertensive effect of the drug persists for more than a day. With regular administration of tablets, the maximum therapeutic effect is achieved within four weeks and is maintained during all long-term therapy.

Pharmacokinetics

What kinetic properties are inherent in the medicine "Diocor 160"? Instructions for use (tablets should appoint only a doctor) states that after taking the drug inside the absorption of hydrochlorothiazide and valsartan is very fast. The average indicator of absolute bioavailability of this drug is 23%.

The kinetics of valsartan is linear. Repeated use of the drug does not change. With a single intake of tablets, their cumulation is negligible.

Valsartan binds to plasma proteins by 94-98%. Its excretion is carried out together with feces and urine. When taking valsartan with food, AUC is reduced by 48%.

After taking the pills inside, the absorption of hydrochlorothiazide occurs fairly quickly (about 2 hours). At the same time, its bioavailability is 60-80%. It is excreted together with urine.

When valsartan and hydrochlorothiazide are combined, the systemic bioavailability of the latter is reduced by about 30%.

Indications for the use of tablets

Under what conditions can a patient be prescribed a medicine "Diocor 160"? Instructions for use, reviews of doctors report that this tool is very well manifested in hypertension, as well as with insufficient effectiveness of monotherapy of this disease.

Contraindications to taking tablets

Do you know about when the Diocor 160 tablets are not prescribed? The instruction says that such a medicine is contraindicated in case of individual intolerance to its ingredients.

In addition, it is prohibited to use in patients with cholestasis, expressed violations of the liver and biliary cirrhosis. Also, it is not prescribed to people suffering from any form of severe and moderate renal dysfunction, a symptom of anuria, a decreased level of sodium or potassium in the blood, hypercalcemia and hyperuricemia.

Diocor 160 tablets: instructions for use

As a rule, to eliminate high blood pressure at home, patients are recommended to use one "Diocor 80" tablet once a day. As for the drug "Diocor 160", it is prescribed only in the hospital. Thus the patient should be under constant supervision of the doctor.

As practice shows, a noticeable effect with severe hypertension is observed 2-3 weeks after the initiation of therapy.

For people with moderate or significant hepatic or renal insufficiency, it is necessary to correct the indicated dosage (individually).

The duration of therapy with this medicine should be determined only by the treating doctor.

Side effects

What kind of side effects should a patient know before using the "Diocor Solo 160" medication? Instructions for use say that the drug in question rarely causes undesirable phenomena that are unstable and weakly expressed.

Approximately 1% of patients on the background of taking this drug had mild headaches, back pain, fatigue, cough, dizziness and nasopharyngitis.

Less than 1% complained of abdominal pain, anxiety, discomfort in the neck and chest, asthenia, joint pain, serous bronchitis, drowsiness, laryngitis, dyspnea, dyspeptic disorders, decreased erection, decreased salivation, hypotension, gastroenteritis, paresthesia, Increased sweating, decreased sensitivity, muscle cramps, sleep disorders, peripheral edema, nausea, otitis, nasal congestion and a slight increase in body temperature. Occasionally, patients experienced visual impairment, unstable tachycardia, and tinnitus. At the same time, it should be noted that the direct relationship between the appearance of these reactions and the drug has not been established.

What other side effects can the "Diocor Solo 160" medication cause? Instructions for use indicate that when using this tool, there were isolated cases of rash, itching and other manifestations of an allergic nature, including vasculitis, as well as serum sickness. In addition, patients sometimes developed myalgia and nephral dysfunction.

The most rare form of side effects when taking the drug "Diocor 160" is a mild noncardiogenic edema, which is associated with the individual intolerance of hydrochlorothiazide.

Studies have shown that in some patients treated with this drug, the potassium content in the blood decreased, the indices of creatinine and urea increased, and moderate neutropenia was detected.

Overdose Symptoms

What are the symptoms when taking large doses of the drug "Diocor Solo 160"? The instruction says that such cases are not known to date.

The main sign of increased intake of medication can be pronounced hypotension. If the drug was taken relatively recently, then the victim is required to artificially induce vomiting. Also, the fight against hypotension can be carried out by intravenous injection of saline.

It should be remembered that it is impossible to withdraw the medicament in question from the body by hemodialysis. This is due to the fact that valsartin, which is part of its composition, reacts with plasma proteins. However, it should be noted that hydrochlorothiazide is eliminated in this way quite successfully.

Drug interaction with other drugs

Is it possible to combine "Diorcor 160" with other means? The instruction says that the combination of this drug with other drugs of the antihypertensive group can contribute to the enhanced effect of reducing blood pressure.

Simultaneous use of the drug with potassium-containing additives, mild diuretics, salt substitutes and substances that increase the potassium content in the body requires regular testing of the concentration of potassium in the blood serum.

With the simultaneous administration of "Diocor" with ACE inhibitors, a reversible increase in the concentration of lithium in the blood was detected.

With what medicines you can safely use the medicine "Dyokor 160"? The instruction informs that under the monotherapy of arterial hypertension this agent did not notice any interaction with Glibenclamide, Amlodipine, Warfarin, Cimetidine, Digoxin, Furosemide, Indomethacin and Atenolol.

In view of the fact that the composition of the drug in question includes a diuretic of the thiazide group, its following interactions are likely:

• Reduction of the diuretic effect of the drug when used together with NSAIDs (for example, salicylates or indomethacin);
• Potentiation of muscle relaxants.

What other drug interactions should you know before taking Dioxor 160? The instruction, the reviews indicate that with the simultaneous use of this remedy with potassium-sparing diuretics, salicylates, ACTH, carbenoxflomone and amphotericin, a sharp decrease in the potassium concentration in the blood is possible.

When using injectable and oral hypoglycemic drugs, it is necessary to individually adjust their dosages.

It is highly not recommended to use this medication together with diuretics of the thiazide group, as this may increase the side effects of the above drugs and cause hypersensitivity reactions.

With the simultaneous use of hydrochlorothiazide with methyldopa, hemolytic anemia can develop.

When combined with the drug "Diocor 160" with colestyramine, its bioavailability and absorption decreases.

When taking the drug with vitamin D in patients can increase the concentration of calcium in the blood.

It is forbidden to take "Diocorus" with cyclosporine, as this can cause gout-like symptoms and a state of hyperuricemia.

Special recommendations for taking tablets

What do I need to know before using Diocor Solo 160? Instructions for use, reviews say that during treatment with this medication the patient should regularly determine serum levels of electrolytes in the blood.

With the development of hypotension, the victim must be transferred to a horizontal position. If required, an intravenous infusion of physiological saline is performed. After stabilizing the pressure, therapy can be continued.

In people with bilateral or unilateral stenosis of the renal artery, taking valsartan can cause an increase in the level of creatinine or urea in the blood.

When medication is prescribed for patients with impaired renal function, dose adjustment is not required, but periodic monitoring of creatinine and uric acid, as well as potassium in the blood, is necessary.

There is evidence that thiazide diuretics can exacerbate systemic lupus erythematosus. They also change the patient's tolerance to glucose, increase the concentration of cholesterol, uric acid and TG in the blood. In connection with this, a diabetic patient may need to adjust the dose of oral hypoglycemic agents or insulin.

In patients with moderate and minor violations of the liver without cholestasis, dose adjustment is not required. But with such conditions, the drug should be taken with extreme caution.

There are reports of cases of photosensitivity against the background of the use of thiazide diuretics. If the photosensitivity reaction occurs during the therapy, the treatment should be stopped.

If it is necessary to reintroduce the diuretic, vulnerable areas should be protected from artificial ultraviolet irradiation or sun.

Drug analogues

How can we replace the means we are considering? According to specialists, such drugs as "Avia-sea", "Dentokind", "Inzen", "Cinnabsin", "Softovac", "Medotsef", "Vinblastine-teva" possess similar properties.

Reviews about the drug

Now you know how to use the medicine "Dyokor 160". Instructions for use of this medication have been described in detail above.

This tool is very popular among patients and doctors. Specialists report that it effectively manifests itself in the presence of severe arterial hyperplasia. Consumers fully agree with this. According to their reviews, taking one pill helps restore blood pressure, as well as alleviate their condition.

It should be noted and the fact that this drug has a convenient form of release and dosage. However, take an increased dose of this medication only in a hospital, under the supervision of a doctor.