Antihypertensive agent 'Enap'. Instructions for use

"Enap" refers to a combination of drugs. It has an active hypotensive and diuretic effect, is available in white tablets (10 units in the outline package).

Enap. Indications for use

Among the antihypertensive agents widely used today in medical practice, the special place is occupied by the drug "Enap". Instruction for use calls several indications for its purpose:

- arterial hypertension;

- left ventricular dysfunction;

- heart failure.

It should be noted that enap is considered a prodrug, its activity is manifested after ingestion, when the constituents of the drug through hydrolysis form enalaprilate, which in turn inhibits ACE.

Active substances of "Enap", in addition to enapril, include hydrochlorothiazide, belonging to the group of thiazide diuretics. The mechanism of combined action of the drug is explained by the decrease in the volume of sodium and liquid in the vessels, which leads to a decrease in cardiac output and blood pressure.

Patients with myocardial infarction are also prescribed the drug "Enap". Instructions for use indicate that taking the medication in such cases helps to reduce the affected area of necrosis and improve metabolism in the heart muscle.

Enap has a positive effect on the kidney circulation, while the drug does not help increase the withdrawal of potassium from the body, which is important in hypertension. This quality of the drug prevents the development of renal insufficiency in patients.

Patients with cardiovascular diseases improve their health with Enap. Instructions for use recommend the drug because of a reduction in the mortality rate observed in patients with congestive heart failure. The effectiveness of the drug does not decrease, depending on the level of renin in the blood plasma, the age of the patient, and his sex. In medical practice, there is no description of the negative effects on the sexual function of the drug "Enap". The instruction also indicates the absence of a negative effect of the drug on fat and carbohydrate metabolism in the body.

The medicine "Enap". Pharmacokinetic properties

Absorption of the active substance occurs mainly through the digestive tract (about 60%), and the process of absorption does not depend on the time of ingestion. After 1 hour, the beginning of the action of the drug "Enap" is observed. The instruction indicates a pronounced therapeutic effect of the drug, which occurs a maximum of 6 hours after its administration, the active effect of the drug persists throughout the day.

Contraindications and side effects

To the contra-indications for the use of the drug "Enap" the instruction relates:

- increased sensitivity of the patient to its components;

- porphyria;

- angioedema ;

- Pregnancy;

Lactation period.

There are a number of side effects that occur in a number of cases of taking Enap. The instruction warns against simultaneous treatment of patients with other diuretics, which can lead to impaired renal function. The work of the kidneys is restored when the drug is withdrawn.

In rare cases, there is arterial hypotension (is of short duration), patients complain of frequent headaches. In some patients, taking medication provokes vomiting and nausea, muscle spasms and skin rashes.

The drug "Enap". Overdose

The main symptoms caused by an overdose of the drug "Enap", the instruction for use calls signs of arterial hypotension. When they manifest the patient should be laid, apply gastric lavage and give activated charcoal. Then, take measures to restore the volume of blood circulating in the body. To do this, the patient is administered (intravenously drip) a solution of sodium chloride, while all vital systems should be taken under control.

To avoid trouble associated with overdose or side effects of the drug "Enap", you must consult with your doctor before going to reception.