Why tablets "Lyrics"? Application, price

The medicine "Lyrics" (tablets), whose price ranges from 700 to 4000 rubles., Is a well-known drug. The active substance is pregabalin, an analogue of gamma-aminobutyric (gamma-aminobutyric) acid (GABA). Later in the article, an annotation will be given to the medicament. Let's find out why the "Lyrics" tablets are used by patients.

Mechanism of action

Pregabalin shows its effectiveness in the treatment of diabetic neuropathy and postherpetic neuralgia, for which the "Lyrics" tablets are prescribed up to 13 weeks with a daily intake 2 times and a course up to 8 weeks with reception 3 times a day. Against the background of the use of the drug, there is an equal development of side effects. Associated with fibromyalgia, an apparent reduction in pain symptoms is noted when taking the drug at doses of 300-600 mg per day. Daily dosages of 450 mg and 600 mg can be compared in effectiveness, but the latter is worse tolerated. The drug reduces the severity of epileptic seizures, for which the "Lyrics" tablets are recommended to be administered at 12 weeks 2 or 3 times a day. In the process of taking the same pattern of side effects and the effectiveness of the drug at this dosage. The frequency of seizures begins to decrease already in the first week of taking the medication. The symptomatology of generalized anxiety disorder shows a tendency to decrease already in the first seven days of treatment. After an eight-week use of the drug, 52% of patients who received pregabalin and 38% of patients taking placebo showed a 50% reduction in the Hamiltonian symptom score (NAM-A).

Pharmacokinetics

Medication Lyrica (tablets) - the instruction confirms this - in recommended daily doses from the pharmacokinetic side is characterized by linearity, low (<20%) interindividual variability. With repeated use, the pharmacokinetics of the drug can be predicted based on single dose data. Therefore, it is not necessary to regularly monitor the concentration of the active ingredient. The pharmacokinetic parameters of the "Lyrics" drug in healthy volunteers, epileptic patients who receive antiepileptic therapy, as well as those receiving the drug for suppressing pain syndromes, are similar.

Absorption and elimination

After taking on an empty stomach, pregabalin is absorbed very quickly. After one hour Cmax is reached in the plasma, both when applied for the first time, and when repeated. On the background of oral administration, the bioavailability of pregabalin is ≥90% and does not depend on the dose. The equilibrium at reception repeated is reached in time 24-48 hours. If the drug is used after a meal, Cmax may decrease by 25-30%, and its achievement will increase by time up to 2.5 hours. But there are no clinically significant effects on the absorption of the drug. Basically, the medicine is excreted by the kidneys unchanged. T1 / 2 averages 6.3 hours.

Pharmacokinetics in special cases

If the kidney function is impaired, it is necessary to take into account that feature of clearance of pregabalin that it is directly proportional to the creatinine clearance. Basically, the drug is excreted by the kidneys, so it is necessary to reduce the dose if their function is impaired. In addition to the kidneys, the medication can be effectively removed from the plasma by hemodialysis (a 4-hour hemodialysis session results in a 50% reduction in plasma concentration in the plasma), after which an additional dose of the drug is desired. A special study of the pharmacokinetics of the "Lyrics" in patients with impaired liver function was not performed.

Pregabalin to metabolism is practically not affected, it is excreted together with urine in the unchanged form, therefore the disturbed function of the liver will not significantly affect the concentration of the drug in the plasma. When the drug is prescribed to patients older than 65 years of age, it must be taken into account that with age, the clearance of pregabalin tends to decrease. If an elderly person has impaired renal function, a reduction in the prescribed dose of the drug is necessary.

Dosage

The daily amount of the drug is determined at 150-600 mg per day. Reception is carried out twice or thrice, regardless of food. Medicament "Lyrics" (tablets) instruction for use recommends taking with neuropathic pain at 150 mg per day. If the achieved effect and tolerance are positive, after a week the daily dose can be increased to 300 mg (prescribe tablets "Lyrics 300"). If there is a need, the maximum dose of 600 mg per day can be prescribed after another week. Similarly, the doses of the drug are calculated in the treatment of epilepsy. As it was said above, the medicine is recommended in the treatment of fibromyalgia, for which the tablets "Lyrics" are prescribed in a dose of 75 mg in two doses per day. The increase in the dose to 300 mg is affected by the effect achieved and tolerance. If there is no positive effect, the dose increases to 450 mg, and if necessary - a week to 600 mg. Treat a generalized anxiety disorder with a dose of 150 mg. Also after a week, observing the achieved effect and tolerability, the daily dose is increased to 450 mg, and after 7 days - to 600 mg (if necessary).

Abolition of the drug

If it is necessary to discontinue treatment, it is recommended to do this at least for a week by gradually reducing the dose. Patients who have impaired renal function are given individual doses. If there are undesirable consequences on the background of receiving the "Lyrics", the analog pills are selected by a specialist. Among the most common remedies with such an action, mention should be made of the preparations "Midokalm", "Apizartron", "Sedavit", "Ambene".

Indications

The medication is recommended for the elimination of neuropathic pain, as an additional therapy for partial seizures of epilepsy, which are accompanied or not accompanied by secondary generalization. The agent is indicated for anxiety disorder of generalized nature, as well as for fibromyalgia.

Contraindications

There is no data on the use of the drug in children and adolescents up to 17 years, inclusive. In this regard, the medication is prescribed only to adults. Contraindications include hereditary diseases in the form of intolerance to galactose, lactase deficiency, as well as impaired absorption of glucose / galactose. The agent is not prescribed for hypersensitivity. A careful prescription of the drug to patients with renal and heart failure is necessary.

Side effects

According to the experience of clinical use of the drug, dizziness and drowsiness are noted as undesirable effects. These phenomena are usually manifested in a moderate or mild degree. Among other side effects that led to the cessation of medication treatment, it is necessary to note asthenia, confusion, blurred vision, impaired coordination, ataxia, and peripheral puffiness. Also among the negative consequences are headache, loss of consciousness, seizures, tongue edema, diarrhea, nausea, keratitis. Rarely itchy itching and angioedema. Possible retention of urine, pulmonary edema and gynecomastia. Among other side effects called increased fatigue.