The preparation "Iodocomb 50/150": analogues, composition, indications for use

Diseases that are associated with a dysfunction of the thyroid gland are very serious. It is not a secret for anyone that it is quite often that such hormonal changes are associated with iodine deficiency. In the arsenal of modern medicine, there are many drugs that can normalize the functioning of the thyroid gland. One of them is "Iodocombe 50/150". Analogues of the medicine, of course, are available, but, according to doctors, they are slightly inferior in effectiveness.

Of course, before starting therapy, patients try to find the maximum amount of information about a particular remedy. So what is included in this medication and how does it differ from other similar drugs? How much does "Iodocombe" cost? How to take pills? This information will be useful to many.

Description of the form of release and composition

This preparation is produced in the form of round tablets with beveled edges of white color. What is included in the drug "Iodocomb"? The active ingredient is potassium levothyroxine sodium monohydrate (in terms of pure form of sodium levothyroxine 50 μg). Potassium iodide is also present (corresponding to a content of 150 μg iodine).

Of course, the tablet formulation also contains auxiliary components, in particular hydroxyl magnesium carbonate, corn starch, hypromellose, microcrystalline cellulose, calcium behenate and colloidal silicon dioxide.

This is the composition of the drug "Iodocomb 50/150". Analogues of it, as a rule, contain only one active component. It is this composition that makes the pills so effective.

How does the drug affect the human body?

For many patients, questions about what the drug is are interesting. Composition of the drug "Iodocomb", analogs, instructions for use, restrictions on the conduct of therapy - all this is very important information. Nevertheless, it is worth considering the particular effects of the drug on the human body.

This is a combined tool, which consists of two active components. Levotiroksin sodium - a synthetic hormonal substance, the mechanism of action which is similar to the influence of natural hormones of the thyroid gland.

The second component is inorganic iodine. As you know, this substance is extremely important for the normal operation of the endocrine system, and the whole body. The daily human need for this mineral is 100-250 μg. In physiological quantities, iodine normalizes the functioning of the thyroid gland, and therefore, the hormonal background of the whole organism. Also this substance prevents the development of goiter caused by iodine deficiency. Normally, people get minerals from food, but to date, cases of iodine deficiency are often recorded. By the way, the effect of this substance on the body largely depends on the dosage form and thyroid condition.

Features of pharmacodynamics

Sodium levothyroxine is absorbed mainly by the walls of the small intestine. If you take the medicine on an empty stomach, then the degree of absorption is 80%. The maximum concentration of this substance in the blood is observed after six hours. A stable level of the hormone is achieved 3-5 days after the start of treatment. Levothyroxine is almost completely (by 99%) bound by plasma proteins.

As for inorganic iodine, it is 100% absorbed by the small intestine. In the human body, this substance accumulates not only in the thyroid gland, but also in the dairy and salivary glands, stomach tissues.

Metabolism of levothyroxine occurs mainly in the liver cells, but also in the kidneys, brain tissues, muscles. Iodine is excreted from the body by the kidneys, and only a small part of it leaves the body together with the feces.

When is it advisable to take Iodocombe tablets?

Of course, patients are primarily interested in the question of when to take the drug "Iodocomb." Indications for use are as follows:

• Diffuse euthyroid goiter, which developed against a background of iodine deficiency in the body;
• As a preventive measure after partial removal or surgery on the thyroid, since the drug can prevent the development of goiter;
• As a preventive remedy, the drug is prescribed to patients who have been treated with radioactive iodine.

It is worth remembering that only a doctor can prescribe taking Iodocomb tablets. Analogues of the drug, by the way, also can not be used independently, as the uncontrolled intake of funds containing iodine can lead to dangerous consequences.

Instructions for use: approximate dosage and general recommendations

Immediately it is worth noting that it is not necessary to take the medicine on your own, especially if it is a violation of the thyroid gland. For the beginning it is necessary to conduct a thorough diagnosis, take tests, check the level of hormones and the presence of contraindications. Only after this, the doctor can prescribe the appropriate drug, determine the dose and duration of treatment.

As a rule, patients are recommended to take one tablet once a day. Ideally, the drug is drunk in the morning, on an empty stomach. The tablet should not be crushed or chewed - it should be swallowed completely, washed down with a small amount of liquid. In the event that the dose of the active substance is not enough, the patient may be recommended to take the same tablets "Iodocomb", but with a dosage of 75/150.

The duration of treatment is determined individually, because it depends on many factors, including the degree of thyroid damage. Treatment, as a rule, lasts for several months, although some patients need lifelong therapy.

Are there any restrictions on admission? List of contraindications

Not in all cases, you can take the drug "Iodocomb 50/150", its analogs or medications containing iodine. Here is the list of contraindications to the therapy:

• Increased secretion of the thyroid gland regardless of the causes of hyperactivity;
• Previously suffered by the patient myocardial infarction;
• Some diseases of the cardiovascular system, for example acute form of myocarditis, angina pectoris;
• Diffuse or focal autonomy of thyroid gland functions;
• Insufficient activity of the adrenal cortex, especially if the patient does not undergo the appropriate treatment course;
• Pituitary insufficiency;
• Hypersensitivity to active or auxiliary components of tablets;
• Herpetiform dermatitis of Dühring;
• The medicine has age limits - it is not prescribed for children and adolescents (under 18 years of age).

In addition, there are a number of relative contraindications. This means that Iodocomb tablets should be taken very carefully and carefully monitor the condition of the body. This group includes diseases of the cardiovascular system, such as tachyarrhythmia, ischemic heart disease, persistent arterial hypertension, heart failure.

In addition, you need to carefully monitor the condition of patients suffering from epilepsy, adrenal insufficiency, sugar and diabetes insipidus. Relative contraindications include long-term hypothyroidism, malabsorption syndrome, and elderly age (if a person is more than 65 years old).

The drug "Iodocomb": side effects and possible complications

It's not a secret for anyone that some drugs can adversely affect the work of the body. Are complications possible with taking Iodocombe tablets? Side effects are possible, although, according to the reviews, they are relatively rare. Here is a list of possible reactions to the drug:

• In some patients there are signs of hyperthyroidism. This, in particular, arrhythmia, tachycardia, sometimes angina. Side effects include weight loss, as well as decreased appetite and diarrhea. Some people complain of insomnia, a constant inexplicable sense of anxiety, and also increased sweating.
• Perhaps the appearance of allergic reactions, which manifest themselves with different symptoms, ranging from skin reddening and rash, ending with swelling, hives, anaphylactic shock.

If therapy is accompanied by the appearance of signs of hyperthyroidism, then it suffices to reduce the daily amount of the drug. Allergic reaction requires withdrawal of the medicine. In any case, if you notice any worsening, it is necessary to consult a doctor as soon as possible.

Is overdose dangerous?

What happens if you take too many tablets of "Iodocombe 50/150". Instructions for use indicate that an overdose is possible, although such cases in medical practice are rarely recorded.

Against the background of taking too much of the drug, arrhythmia, tachycardia, tremor may occur. Some patients experience increased sweating, diarrhea, insomnia, a strong sense of anxiety. With prolonged therapy, a sharp decrease in body weight is possible.

If it is a question of long-term admission of large doses of the drug, then patients are simply recommended to reduce the daily amount of the drug. In acute poisoning, gastric lavage is performed, followed by symptomatic therapy. Plasmapheresis is prescribed when taking a critical dose.

Features of interaction with other drugs

• If the patient suffers from hyperthyroidism, then it is necessary to avoid the intake of iodine in the body.
• Joint reception of this drug with "Amiodarone" can lead to the development of both hyperthyroidism and hypothyroidism.
• Such drugs as "Kolestipol" and "Kolestyramin" reduce the absorption of levothyroxine sodium. That's why drugs should be taken with a break of at least 4-5 hours.
• The absorption process of levothyroxine is influenced by the intake of preparations containing iron salts, as well as antacids containing aluminum. Therefore, doctors recommend taking Iodocombe tablets at intervals of not less than two hours.
• The rapid introduction of "phenytoin" (intravenously) often leads to a sharp increase in the level of free levothyroxine in the blood. In turn, this can lead to various violations of the heart rhythm.
• High doses of salicylates, Furosemide, Dicumarola, and Clofibrate (250 mg or more) reduce the binding of levothyroxine to plasma proteins.
• Simultaneous reception of "Iodocomb" and anticoagulants can enhance the effect of the latter. If for one reason or another the patient needs to use two drugs at once, it is very important to constantly monitor the degree of clotting of the blood in order to avoid massive bleeding.
• Levothyroxine may weaken the effect of hypoglycemic drugs. In the treatment of patients with diabetes it is very important to monitor the level of glucose in the blood. If necessary, you can correct the daily dose of hypoklikemic drugs.

The drug "Iodocombe 50/150": analogues and substitutes for the medicine

Sometimes in therapy there is a problem when a patient prescribed for a particular reason does not fit the drug prescribed for him or her. Is it possible to replace the drug "Iodocomb"? Analogues exist, although there are not so many of them in the modern pharmaceutical market. In some cases, the drug "Yodtirox" may be included in the course of therapy, which has approximately the same properties. This is a good analogue of the tablets "Iodocomb 50/150".

In addition, the drug can be replaced with two separate medicines (eg, Bagotiroks and Potassium iodide, L-thyroxine and Iodomarine, Eutirox and Iodine Balance). In any case, you should not look for substitutes yourself - only a specialist can choose high-quality and safe medicines.

How much are the pills?

Of course, the cost of the drug is no less important. In fact, the price of tablets is quite affordable and ranges from 380 to 520 rubles. It is necessary to understand that the actual figures may differ slightly, since the cost depends on many factors, including the city of purchase, the policy of the pharmacy, the distributor, etc. In some cases, several packages may be needed to complete the therapy.

Reviews of doctors and patients

Patients are often interested in the opinion of specialists, as well as people who took the pill "Iodocomb 50/150". The reviews are mostly positive, both on the part of the doctors and the patients. Doctors note the good effect that this drug provides. With the help of a properly selected therapy regimen, thyroid function can be normalized. As a preventive measure, this remedy also works well.

Patients say that the medicine is transferred perfectly, rarely causing any side effects. Even if some deterioration appears, they can be eliminated with a simple dosage adjustment. To disadvantages can be attributed unless the price. On the other hand, the cost of tablets is not so great, especially if we take into account their effectiveness.