The drug "Ofloxacin": reviews of patients. Instructions for the use of the antibiotic "Ofloxacin"

The drug "Ofloxacin", reviews of which are mostly positive, is an antimicrobial agent from the group of fluoroquinolones of a wide spectrum of activity. The drug has an effect on DNA-girase - a bacterial fragment that provides super-convolution and, as a result, the stability of DNA bacteria (as a result of destabilizing the DNA chain, they die).

Pharmacodynamics

"Ofloxacin" is an antibiotic effective against microorganisms that produce beta-lactamases, as well as atypical fast-growing microbacteria. Most of the Gram-negative bacteria show sensitivity to the medicine, including microflora, resistant to methicilin and other antibiotics. Streptococci, enterococci and microbacteria of tuberculosis are characterized by a non-permanent susceptibility to the drug "Ofloxacin". The doctors' testimonies indicate that in the treatment of anaerobic infections caused by peptostreptococci, peptococci and other anaerobes, the drug is often ineffective.

Pharmacokinetics

After taking the medication, the absorption inside is complete (95 percent) and fast. Bioavailability is more than 96 percent. The connection with plasma proteins is 25 percent. One to two hours after oral administration, the highest concentration is achieved. It depends on the dose: with a single use of two hundred, four hundred or six hundred milligrams of medication, the concentration is 2.5, 5 or 6.9 μg / ml, respectively.

Eating can affect suction in the direction of its slowdown, but the bioavailability is not significantly affected. The drug "Ofloxacin" - an antibiotic, which has a significant volume of distribution (one hundred liters), so the injected drug almost freely penetrates into the cells. Maximum concentrations are created in tissues, liquids and organs: in cells (alveolar macrophages, leukocytes), soft tissues, skin, bones, respiratory system, pelvic organs and abdominal cavity, saliva, secretion of the prostate, urine, bile. The drug penetrates well through the placental and blood-brain barrier, is secreted with the mother's milk, and also enters the cerebrospinal fluid with non-inflamed and inflamed shells of the brain (14 to 60 percent).

About 5 percent of the drug is metabolized in the liver to form dimethylfloxacin and H-oxide-ofloxacin. Regardless of the dose, the elimination half-life is between four and a half to seven hours. The drug is unchanged in an amount of 75-90 percent of the kidneys, in an amount of 4 percent - with bile. Less than 20 percent is extrarenal clearance. After a single intake of two hundred milligrams in the urine, the agent is detected within 20-24 hours. In the case of hepatic or renal failure, excretion may be delayed. When hemodialysis is eliminated from 10 to 30 percent of the drug.

Indications for use

When infectious inflammatory diseases caused by various microorganisms, it is shown to use the medication "Ofloxacin". The reviews say that it is good for respiratory infections (pneumonia, bronchitis), ENT organs (otitis media, sinusitis, laryngitis, pharyngitis). Assign a drug for the lesions of soft tissues, joints, bones, skin, bile ducts, urinary tract (urethritis, cystitis), kidneys (pyelonephritis), abdominal cavity, genitals (orchitis, colpitis, epididymitis), pelvic organs (salpingitis, prostatitis, Cervicitis, endometritis, oophoritis, parameter).

The drug is also effective for ureaplasmosis, chlamydia, gonorrhea. They use it to prevent the development of infections in patients with immune status disorders (including neuropathy).

Dosage form. Composition

Release of the medication is carried out in the form of biconvex round tablets covered with a white or almost white film shell. On the cross-section, two layers are noticeable, one of which has a yellowish tinge. The active ingredient is ofloxacin. In one tablet, it is contained in a mass of 200 or 400 milligrams. Secondary ingredients are impellosis (croscarmellose sodium), microcrystalline cellulose, aerosil (colloidal silicon dioxide), titanium dioxide, povidone, hydroxypropylmethylcellulose (hypromellose), talc, magnesium stearate, polyethylene glycol 4000 (macrogol). The great value of the medicine "Ofloxacin" is the price. Tablets with a content of 200 milligrams of active substance cost an average of 16-20 rubles per 10 pieces, and those that contain 400 milligrams ofloxacin will cost about 50-55 rubles per 10 pieces.

Medication «Ofloxacin». Instructions for use

Tablets should be taken before or after meals. They need to be swallowed whole, without chewing, and wash down with water in small amounts. Dosage should be selected individually, depending on the severity of the disease, the localization of the infection, the general condition of the patient, the functioning of the kidneys, liver, and the sensitivity of bacteria.

Typically, the treatment of "Ofloxacin" is carried out for seven to ten days. Adults receive a daily intake of two hundred to six hundred milligrams twice a day. The dose can be increased to eight hundred milligrams in the event of a serious infection or if the patient is overweight. A dose of four hundred milligrams can be taken at a time, preferably in the morning.

Patients with impaired renal function can not take more than two hundred milligrams of medication once a day, the maximum dose per day for hepatic insufficiency is four hundred milligrams. After the disappearance of the symptoms of the disease and the normalization of the temperature for another two to three days should continue therapy.

Adverse events. Patient Reviews

Not all patients are well tolerated drug "Ofloxacin." Some people's reviews contain information that the drug causes headache, nausea, vomiting, diarrhea, tremor, numbness of the limbs. On the part of the digestive system, abdominal pains, gastralgia, flatulence, cholestatic jaundice, anorexia, hyperbilirubinemia, pseudomembranous enterocolitis, and nervous system - uncertainty of movements, convulsions, intense dreams, psychotic reactions, agitation, anxiety, confusion, phobias, Hallucinations, depression.

In addition, there is a risk of disturbances in the motor apparatus (arthralgia, tendinitis, myalgia), sensory organs (taste disorder, color perception, hearing, balance, olfactory), vascular and heart system (lowering blood pressure, tachycardia), skin (dermatitis, spot Hemorrhage, papular rash), hematopoiesis (thrombocytopenia, anemia, leukopenia). After taking the drug "Ofloxacin" (reviews confirm this), in some cases, itching itch, bronchospasm, hives.

Contraindications

Medication administration is prohibited when orloxacin and other fluoroquinolone derivatives are intolerant, in case of deficiency of glucose-6-phosphate dehydrogenase, with epilepsy, tendon lesions, lowering convulsive threshold. In addition, you should not take the drug "Ofloxacin" pregnant and lactating women, children under the age of eighteen. With caution, the drug is prescribed for circulatory disorders in the brain, atherosclerosis of the brain vessels, renal failure in chronic form, lesions of the central nervous system of an organic nature.

Medication "Ofloxacin" with ureaplasma. Reviews

The main thing that people who use the drug mention is its quick effect. Patients report that the result is noticeable already on the third or fourth day. But it is worthwhile to warn that this does not mean the onset of cure. Those patients who stopped drinking pills without going through the full course, then again experienced symptoms of ureaplasmosis, because the bacteria were not completely eliminated.

special instructions

With pneumonia, triggered by pneumococci, the drug is ineffective. It is also not indicated for the treatment of acute tonsillitis. It is necessary to cancel the drug, if against the background of its reception there are allergic reactions, disorders of the central nervous system, pseudomembranous colitis. Women who use the drug "Ofloxacin", it is not recommended to use tampons, since in this case there is an increased risk of thrush development.