How is the 'Lokoid' ointment applied?

Ointment "Lokoid" is used in the treatment of diseases such as psoriasis, as well as unspecified, atopic and contact dermatitis. The main active substance in this medicine is hydrocortisone 17-butyrate, as a base is used petroleum jelly, ointment is used as an external agent. Ointment "Lokoid" is available in aluminum tubes, which also have an aluminum membrane. It has a uniform shape, oily to the touch, translucent, the color can be from white to light gray.

Ointment "Lokoid" is characterized by local anti-inflammatory, as well as antipruritic and anti-edematous action. After applying the ointment to the body, the active substance gradually accumulates in the upper layers of the skin, namely in the epidermis, the systemic absorption of this ointment is insignificant. There is also an absorption of a small amount of hydrocortisone 17-butyrate in the systemic blood stream unchanged.

Ointment "Lokoid", or rather its active substance hydrocortisone 17-butyrate, is metabolized to hydrocortisone, as well as other metabolites, directly in the epidermis and only after that in the liver. Formed metabolites and also part of the unchanged active substance is excreted through the intestine and kidneys.

"Lokoid" ointment - application

If you use the ointment in the recommended amounts, then there is no suppression of the hypothalamic-pituitary-adrenal system. Incorrect use of the drug or its use in large quantities and a long period of time even under occlusive dressings gradually leads to an increase in the amount of cortisol in the blood plasma, but very rarely causes a decrease in the reactivity of the pituitary-adrenal system. After the abolition of the use of this drug all quickly comes back to normal.

The lokoid is used for various superficial uninfected skin diseases. These include such types of dermatitis as seborrheic, contact, atopic; Eczema and psoriasis.

Contraindications to the use of this drug

All cases where the human body is hypersensitive to hydrocortisone or other components of the drug, as well as in the presence of bacterial skin infections, for example, gram-negative follicle, strepto- and staphylodermia and others. Also, the use of the drug is not allowed if a person has viral, fungal and parasitic skin infections, tuberculosis lesions, as well as syphilitic skin lesions, any tumors and in the post-vaccination period. Care should be taken if the patient has a sick wound or ulcers and is not recommended for women during pregnancy and lactation. In pregnancy, GCS penetrates the fetus through the placenta, especially this is pronounced when treating large areas of the skin.

Side effects

They can be expressed in the irritation of the skin. If the drug is taken for a long time, then side effects may appear, which are typical for all systemic SCSs. The use of lokoid causes much less side effects than the use of fluorinated steroids. Currently, there is no evidence of an overdose of this drug.

The drug is applied to the affected skin areas up to 3 times a day in a thin layer, in order for the drug to function better, it is necessary to perform massaging movements when applying it. For a week, do not use more than 60 grams of the drug.

Do not apply the drug around the eyes, so as not to provoke the development of glaucoma, and with its constant impact on the conjunctiva, the intraocular pressure may increase . On the scalp of the body, for example on the head, in the genital area it is better to use the cream "Lokoid".

"Lokoid" ointment, analogues of which "Lokoid Krelo" and "Lokoid Lipocream" also have a rapid anti-edematous, anti-inflammatory, antipruritic effect, but have a softer effect, sold without a doctor's prescription.