The drug "Nicergoline": reviews, instructions for use

Is the drug "Nicergoline" effective? Reviews, analogues and features of this tool will be discussed in the article. You will also learn about the dosage it is administered to patients.

Description, composition, form of the medicinal product

In what form do they produce the drug "Nicergoline"? The instruction says that this tool can be purchased in two forms:

• The lyophilizate in glass ampoules (i.e., white odorless powder), packaged in PVC contour boxes and cardboard boxes, respectively, together with a solvent (0.9% sodium chloride), intended for the preparation of the injection solution.

What is included in this tool? It contains nicergoline, as well as milk sugar and tartaric acid.

• Biconvex tablets with a white film shell, packed in blisters.

What components does the form of the drug "Nicergoline" include? In addition to the active ingredient of the same name, the tablets include the following substances: potato starch, magnesium carbonate basic, milk sugar, povidone, stearic acid and magnesium stearate.

As for the white shell, it consists of basic magnesium carbonate, sucrose, colloidal silicon dioxide, beeswax, povidone, titanium dioxide, medical gelatin and talc.

Pharmacodynamic features of the agent: characteristics

This agent has a vasodilating effect (that is, it affects the cerebral arteries), and also belongs to the group of alpha-adrenoblockers.

The drug "Nicergoline-LF", which is described below, is a synthetic derivative of the alpha-adrenoblocker and ergot alkaloids. The chemical formula of this agent contains the residues of bromo-substituted nicotinic acid.

The active component of the drug, as well as the ergoline derivative, contribute to a positive effect on the hemodynamic and metabolic processes that occur in the human brain.

Due to the fact that the drug in question has an alpha1-adrenergic blocking effect, its administration increases the blood flow velocity in the lungs, brain and limbs, and also reduces platelet aggregation in the blood and improves its hemorheological indices. Also, this drug compound exhibits antispasmodic properties and at the same time has a miotropic effect on the vascular musculature, increases the permeability of glucose and equalizes the effect of the ergoline ring.

Main properties of the medicine

What is remarkable about such a tool as "Nicergoline"? Experts say that this medication reduces the tone of blood vessels, saturates the arterial blood stream with oxygen and glucose. It also has a beneficial effect on blood pressure, which, with hypertension, can gradually be normalized.

It should also be noted that the drug in question contributes to the improvement of hemorheological indices, as well as a decrease in platelet aggregation and increased blood circulation in arteriopathy.

Pharmacokinetics of medicament

The drug "Nicergoline," which is mostly positive, reviews its maximum concentration in the blood 90 minutes after the first application. The biological availability of this agent is about 60%.

From the patient's body, 80% of the medicament is excreted by the kidneys (with urine), and 20% - along with the feces.

Indications for use

When patients are prescribed the drug "Nicergoline"? Reviews (tablets and injections with this name are sold in all pharmacies) say that the main indications for using this medication are the following conditions:

• migraine;
• Disturbances in the work of metabolic cerebral vessels of a chronic or acute nature caused by atherosclerosis, hypertension, ischemic attack, embolism, vasospasm, thrombosis or vascular dementia;
• Raynaud's disease;
• Vertigo;
• Angiopathy is diabetic ;
• Circulatory disturbance (peripheral);
• Diabetic retinopathy;
• Endarteritis;
• Optic nerve neuropathy;
• Arteriopathy of extremities;
• Diseases of the cornea.

Contraindications for use

What conditions of the patient forbid using the medicine "Nicergoline"? Reviews (injections and tablets have the same contraindications) talk about the following prohibitions:

• Hypersensitivity;
• Intolerance to galactose;
• Suffered heart attack;
• Hypotension;
• pregnancy;
• Bradycardia;
• Underage age;
• breast-feeding;
• Glucose-galactose malabsorption;
• Lack of lactose.

With caution, this drug should be used by people with gout, hyperuricemia, and also in combination with drugs that affect metabolism and the excretion of uric acid from the body.

"Nicergoline" medication: instructions for use

The doctors' comments say that this remedy should be taken in strictly recommended dosages. As a rule, tablets "Nicergoline" are prescribed thrice a day before eating or during meals at a dose of 5-10 mg.

The duration of treatment with this medication is usually 3 weeks. But if necessary, this period can be increased to several months.

Before use, the lyophilizate "Nicergoline" should be diluted with a solvent (with sodium chloride), and then administered intramuscularly (twice a day for 2-4 mg). The duration of therapy and dosage of this drug depend on the severity and nature of the disease, as well as on the condition of the patient.

People with impaired renal function are recommended to use the drug in the smallest possible amounts.

Side effects after applying the medicine

The side effects in the instructions to the drug "Nicergoline" are prescribed. Comments from consumers report that during the application of the drug in question they often had such adverse reactions as:

• Nausea, decreased blood pressure, drowsiness;
• Abdominal pain, allergic reaction, dizziness;
• Fever, diarrhea, increased uric acid levels, insomnia.

Overdose, drug interaction

What are the symptoms when using large doses of the drug in question? Signs that signal an overdose are conditions such as orthostatic collapse, hypotension, and allergic reactions. In addition, when the dosages recommended by the doctor are exceeded, the severity of side effects is significantly increased in patients.

According to the instructions, the drug "Nicergoline" is able to enhance the effectiveness of antipsychotic and hypotensive drugs, as well as anxiolytics. It should be noted that antacids and colestyramine reduce the absorption of this medication.

When the drug is used in parallel with adrenostimulators, idiosyncrasy may occur in patients.

The drug "Nicergoline": reviews of patients and doctors, analogues

Analogues of this remedy are such drugs as "Nilogrin", "Sermion" and "Nicergolin-Fereyg".

The medicament in question is strictly forbidden to be used together with narcotic drugs and alcoholic beverages.

To avoid the development of hypotension, including at the very beginning of therapy, after intramuscular injection of the drug solution, patients should remain in a horizontal position for some time.

It should also be noted that most doctors during treatment with the drug "Nicergoline" forbid their patients to sit behind the wheel of vehicles, as well as engage in activities that require instant psychomotor reactions and increased concentration.

As for consumers, their main part leaves negative reviews about the drug "Nicergoline". This is due primarily to the fact that patients very often face its side effects, and for a long time do not note any improvement and drug effect.