The drug "Maprotilin": reviews, instructions, analogues

In the last century, such nervous disorders as anxiety, depression and insomnia, were treated mostly only by ansiliotics. These drugs were considered effective, but, unfortunately, caused dependence in patients. Therefore, in the 80-ies in many countries of the world from their application refused. Today, the most promising type of drug for depression is considered to be selective drugs. One of the most popular means of this group, which deserved good reviews of patients, is "Maprotiline". Another name for this light tetracyclic antidepressant is "Ladomil". In pharmacies, it is sold only on prescription.

general description

The benefits of the drug "Maprotiline", reviews about which there are actually quite good, doctors and their patients primarily include a well-balanced wide range of sedative, anxiolytic and antidepressant actions. When this medication is taken, anxiety is eliminated in patients, mood improves, excitability decreases, psychomotor retardation disappears.

How it works

Getting into the digestive tract, "Maprotiline" begins to slowly suck in the blood and 89% binds to proteins. Its maximum concentration in plasma is observed only 8-9 hours after administration.

In the patient's body, the drug selectively inhibits the seizure of serotonin and norepinephrine by neurons in the cerebral cortex. In addition, the drug blocks some receptors. Absorbed in the body completely. Also, it is largely metabolized. "Maprotiline" is excreted from the body very slowly - for about 3 weeks (with urine and feces).

Indications

In what cases can the doctor prescribe the drug "Maprotilin" to the patient? The use of this drug is considered justified in many mental disorders. Most often, indications for the use of the drug are depression:

• Endogenous, including involutional;
• Psychogenic, including reactive and neurotic;
• Somatogenic;
• Menopause.

Also, this medicine is often prescribed by doctors with a depressed mood with anxiety elements. Well respond about this tool and, for example, the elderly. They usually write this drug for apathy. In some cases, the reason for prescribing the medication is irritability or dysphoria. It is treated also by somatic disorders caused by depression or fear.

Composition

The main active substance of the drug is maprotiline - a four-ring compound. According to its pharmacological properties, it is considered a close tricyclic antidepressant. This is due, first of all, to its structure (especially along the side chain). Like tricyclic antidepressants, the drug "Maprotiline" enhances the action of phenamine. In doing so, it weakens some of the effects of reserpine.

"Maprotiline": reviews of patients about the medicine

Most patients find this drug effective enough. After the patients start to drink it, their mood rises and most of the signs of depression disappear. To many patients, judging by the available reviews, this medicine perfectly helps to cope with anxiety and even panic attacks. Some patients who drink "Maprotiline," note the fact that they finally had an interest in life.

Good reviews of this medicine are available not only in adult patients. Praise him and the parents of children, as well as adolescents suffering from mental disorders.

The disadvantages of the drug "Maprotiline" ("Ludomil"), reviews of which are, unfortunately, not only good, many patients attribute the fact that its reception can cause quite unpleasant side effects. For example, some patients complain that after the doctor prescribed this medication they began to recover strongly and quickly. Also, some patients note the fact that this drug can cause a delay in urination or even cause hair loss. The main unpleasant side effect of this drug patients consider dry mouth. Some patients who drink it even have problems with the gums.

Of course, despite the fact that this drug is really very effective and relatively "light" ("Maprotiline"), it should be taken only under the supervision of a doctor. On some patients, it does not work at all. Other patients note, unfortunately, even the deterioration of their condition.

Opinions of doctors

From doctors also receives basically good "Maprotilin" reviews. Many doctors-psychiatrists believe that he takes off the alarm very well. In this case, according to experts, the side effects of the drug "Maprotiline" is less than in tricyclic AD. Like patients, doctors believe that the main unpleasant consequences of taking this drug are dry mouth and a set of excess weight. To the minuses of this medicine, among other things, experts also refer to the fact that it can cause convulsions.

With regard to accessibility, there are also not too good reports about the medicine "Maprotiline" from doctors. In the clinics, it is quite rare. It is difficult to find it in pharmacies. Previously, this drug was supplied for sale much more often. But, as some doctors note, before disappearing from pharmacy shelves, it almost ceased to have a positive effect on the health of patients. Perhaps, the manufacturers of this drug had some problems with its manufacture.

Contraindications

Of course, the medicine "Maprotiline" (reviews allow to judge it as effective enough) can not be prescribed to all patients suffering from mental disorders. Contraindications to its use are:

1. Epilepsy. The prohibition extends in this case and for the period of the anamnesis.
2. Hypersensitivity.
3. Myocardial infarction. This drug is not prescribed in the acute period of this disease.
4. Glaucoma is a closed-angle character.
5. The patient has problems with intraventricular conduction.
6. Alcohol or narcotic intoxication.
7. Admission to patients with large doses of hypnotics.

Do not administer this medication to patients also with delayed urination, liver or kidney failure. Also, contraindication to its use is pregnancy and lactation.

In adolescents with suicidal tendencies, like many other antidepressants, tablets "Maprotiline" can stimulate thoughts of suicide. This medication usually does not affect adult adults of this effect.

Elderly, this drug is most often prescribed in reduced doses.

Instructions for use

In most cases, patients with the drug "Maprotilin", whose reviews are also good because of the ease of use, is prescribed in tablets. Drink them, like almost any other, followed with water. Chew tablets are not recommended. For adolescents and the elderly, this medication is usually prescribed at 10 mg 3 times a day. If the desired effect does not occur, the amount of the drug taken is most often increased to 25 mg. Depending on the patient's response, in some cases, a single dose of 75 mg may be prescribed.

For adults, the dosage is determined individually. For mild disorders, outpatient patients are usually prescribed 25 mg of the drug "Maprotiline" 1 time per day. In the hospital, patients are prescribed 25 mg of medication most often 3 times a day. In especially severe cases, the dose may increase to 150 mg per day. Such amount of medicine is considered as a maximum allowable per day.

Sometimes oral therapy with the use of the drug "Maprotiline" does not help patients. In this case, the doctor can prescribe intravenous administration. For the treatment of the patient put under the dropper and injected 25-100 mg for 1.5-2 hours once a day. The first improvement in patients taking "Maprotiline", usually noticeable within two to three weeks.

Side effects

Thus, relatively simple for the drug "Maprotiline" instructions for use. Reviews about it also exist good. However, the side effects of this drug, as it was already possible to guess, there are many. In addition to dry mouth and weight gain, the use of this drug, according to the manufacturer, can cause such unpleasant consequences as:

• Epileptic seizures;
• Dysarthria;
• weakness;
• Lethargy and fatigue;
• Hallucinations and manic conditions;
• Confusion;
• Hearing impairment;
• A violation of taste.

Also, patients taking this medicine can observe:

• nausea;
• Constipation or diarrhea;
• Allergic reactions in the form of hives or itching;
• Edema.

There are side effects from taking this drug and all sorts of sexual deviations.

The medicine "Maprotilin": analogues

In pharmacies, this drug can be found, as already mentioned, not always. However, if necessary, it can, of course, be replaced by some other medicine with the same pharmacological effect. Analogues of the drug "Maprotilin" are, for example:

• "Melipramine."
• Ixell.
• "Amitriptyline."
• "Imizin".

In some cases, you can replace "Maprotiline" with "Clofranil" and "Saroten".