The drug "Cloffee" - what is it? Substitutes "Clofelina"

Do all people who have heard of the Clofelin drug know what such medicine provides to the human body? Unfortunately no. And this is a wonderful tool that can reduce blood pressure. The drug has a calming effect on the central nervous system. The drug "Clofelin" is also capable of reducing intraocular pressure. In addition, it reduces the frequency of heart contractions.

Pharmacological properties of the preparation

So, the remedy "Cloffee". What is the medicine that gives the body? The drug has strong hypotensive and sedative properties.

He simultaneously has several actions:

• Reduces peripheral resistance of blood vessels (including those located in the kidneys);
• Lowers patients' intraocular pressure;
• Reduces cardiac output.

In some cases, a persistent reduction in blood pressure may exhibit a hypertensive property. As a rule, its duration is several minutes.

It is necessary to know those patients who are prescribed the drug "Cloffee", that such a drug in small doses has the necessary effect. The medicine works quickly. And at the same time a long period. After taking this remedy after a couple of hours, a steady effect appears. It lasts about 8 hours.

When the drug "Clofelin" is combined with certain medicines or alcohol, the hypotensive effect may be intensified or the side effects may be aggravated. It is impossible to exclude even death. That is why it is necessary to purchase such a remedy as "Clofelin", a doctor's prescription. Without it, the drug is not released.

Forms of release

This drug is available in three medicinal forms:

• pills;
• eye drops;
• Solution for intravenous administration.

Application of the drug

Extremely popular for stopping a person's hypertensive crisis means "Clofelin". Symptoms that indicate a rise in blood pressure make it possible to eliminate the previously taken medicine in time.

Thus, the drug "Cloffee" is assigned under the following conditions:

• hypertensive crisis;
• Arterial hypertension (including kidney pathology);
• Pheochromocytoma (for diagnosis);
• Acute myocardial infarction (without symptomatic cardiogenic shock);
• Dysmenorrhea;
• Headaches of vascular nature;
• Abstinence syndrome in people with drug dependence (in complex therapy);
• Nicotine addiction.

It is recommended to apply the drug "Clofelin" (drops), to treat open-angle primary glaucoma.

Contraindications

Must remember the patients who are prescribed the drug "Cloffee", that such a drug is prohibited to eat with the following factors:

• Hypersensitivity;
• Arterial hypotension;
• Cardiogenic shock;
• Atherosclerosis of brain vessels;
• Obliterating pathologies of peripheral arteries;
• AV-blockade of 2-3 degrees;
• Pronounced sinus bradycardia;
• Depression;
• Porphyria;
• Syndrome of weakness of the sinus node;
• Pregnancy;
• Lactation period;
• Hypersensitivity to clonidine;
• Inflammatory diseases of the anterior parts of the eyes (for drops).

Simultaneous administration of the drug with ethanol and other agents that exert a depressing effect on the central nervous system is not permissible. It is forbidden to use together the drug "Clofelin" and alcohol!

Dosage of the drug in tablets

Before taking the medicine, you should carefully read the instructions. Like any medicine, the drug can alleviate the condition of the patient. But in case of misuse, it can cause serious damage to health. That's why the drug "Clofelin" should be used strictly according to the doctor's prescription and only in prescribed dosages.

The instruction gives the following recommendations for taking the drug in tablet form:

1. They are taken orally, without chewing, after or during a meal. Drink the pill with liquid.
2. Dosage for each case is selected individually.
3. Therapy should be started with a small dose - 2-3 times a day for 0.075 mg.
4. If the hypotensive effect is not sufficiently expressed, the reception of the drug is gradually increased. The dose every 1-2 days increases by 0.0375 mg. Until it reaches 0.15 mg.
5. Elderly patients, especially in the presence of cerebrovascular sclerosis , the initial dose prescribed 0.0375 mg.

Application of the drug in ampoules

For the given dosage form, the instruction gives the following recommendations:

1. Ampoules are used for intramuscular, subcutaneous or intravenous administration.
2. In the case of hypertensive crisis, 0.5-1.5 ml of 0.01% solution is recommended. The introduction is carried out intramuscularly or subcutaneously. If the desired effect is mild, injections are prescribed 3-4 times a day.
3. For intravenous injection of 0.5-1.5 ml of a 0.01% drug is diluted in an isotonic solution of sodium chloride - 10-20 ml. Injection is very slow.

Use of eye drops

For this preparation, the following is recommended for use with the instruction:

1. In the conjunctival sac, 2-4 times a day for 1-2 drops are instilled.
2. Therapy starts with a 0.25% solution. With insufficient decrease in intraocular pressure, a 0.5% preparation is recommended.
3. If a patient develops side effects, then he is prescribed a 0.125% solution. And sometimes completely abolish the drug.

Side effects

At patients during reception of a preparation "Klofelin" enough different reactions can be observed.

1. Lymphatic system, blood. An elevated level of sugar may be observed.
2. CNS. Some patients experience an unpleasant headache, temporary confusion, paresthesia, tremor, hallucinations, increased fatigue, and weakness. Sometimes there is drowsiness, nervousness, slowing of psychomotor reactions, anxiety, depression, dizziness. Patients can see bright or nightmarish dreams. There are cases of anorexia.
3. The cardiovascular system. The drug is able to provoke bradycardia, puffiness, Raynaud's syndrome, orthostatic hypotension, AV blockade.
4. Organs of vision. There may be a decrease in the secretion of the lacrimal gland secretion.
5. Organs of hearing. There is pain in the parotid gland.
6. Respiratory system. The patient may experience nasal congestion. Sometimes there is a violation of breathing.
7. GIT. In this case, the patient's appetite decreases, nausea, dry mouth, vomiting, constipation occurs. There is a decrease in gastric secretion.
8. Skin covers. Itching, alopecia. Sometimes there is a skin rash. Very rarely there is swelling of the mucous membranes.
9. Urinary system, kidneys. The body retains fluid. Noticeably decreases urination. The delay of sodium and water leads to an increase in body weight.
10. Reproductive system. Violated sexual function. There may be a decrease in potency. Men can develop gynecomastia.

If the patient has such reactions of the body, you should immediately report them to the doctor. In no event can you refuse to take your own "Clofelin" medication. The consequences of a sudden discontinuation of the drug may be serious. The development of hypertensive crisis is not ruled out .

During the use of drops, adverse reactions can occur in the form of:

• Dryness of the conjunctiva;
• Burning sensation in the eyes.

You can not exclude the possibility of manifesting some of the symptoms described above.

Substitutes of the preparation

Like any other drug, there are analogues for the drug "Cloffee". Substitutes of medicine are never worth choosing on their own. It is extremely difficult to make an accurate selection.

Only the doctor will be able to correctly choose the substitutes for the drug "Cloffee". He will take into account both the form of release and dosage. Do not forget that a full analogue of this remedy, which does not harm your health, will be recommended only by a doctor.

So, what is the substitute for "Cloffee"? Physicians provide a list of drugs that can become an excellent analog:

• "Apo-Clonidine."
• Athenzina.
• Bapresan.
• Barklid.
• "Hemiton".
• "Gipozin".
• "Capresin".
• "Ipotenzin."
• Catapresane.
• "Catapres".
• Clonidine hydrochloride.
• "Clonilon".
• "Clonidine."
• "Clonisin".
• "Clofelin-M".
• Normopresane.
• "Namedin".
• "Predskatan".
• "Chloridine."
• "Chlofazolin."

An overdose of a medicine

Do not ever deviate from the medication prescribed by your doctor. Because the consequences of such a decision are fraught with serious complications.

Overdose of the drug is able to show symptoms:

• Indomitable vomiting;
• drowsiness;
• Lethargy;
• hypothermia;
• Impaired consciousness;
• Xerostomia;
• Respiratory depression;
• collapse;
• Possibly delayed atrioventricular conduction;
• Increase or decrease of pressure;
• Bradycardia;
• Miosis (narrowing of the pupils);
• Syndrome of early repolarization.

If these signs are present, the patient needs symptomatic treatment. It is based on the following recommendations:

1. With the emergence of apnea, the patient must enter the drug "Naloxone" intravenously in an amount of 2-4 mg.
2. If necessary, the injection of the above-mentioned agent is repeated.
3. In the case of a severe overdose of the drug "Clofelin", electrocardiostimulation is recommended.
4. If the patient develops bradycardia, the drug Atropine is effective.
5. An excellent antidote to the drug "Clofelin" is the drug "Tolazolin." The above preparation in an amount of 10-50 mg is able to neutralize the effect of taking 0.6 mg clonidine.

special instructions

In modern therapeutic therapy, the drug "Clofelin" is practically not used. It is not used because of a characteristic sharp decrease in pressure. This effect is short-lived. In the following, an increase in pressure is observed. It is a question of the hemithon crisis.

The drug is not recommended in case of withdrawal syndrome in patients with drug dependence. It is not prescribed for vasomotor malfunctions on the background of dysmenorrhea and menopause. It is undesirable to use the drug in acute myocardial infarction. In such cases it is better to use imidazoline receptor agonists.

In the case of long-term administration of the Clo-phenil remedy, it is necessary to control the intraocular pressure.

The drug is able to enhance the effect of drugs that oppress the functioning of the central nervous system, ethanol. Diuretics, vasodilators, antihistamine medicines increase the effect of clonidine on the body. Tricyclic antidepressants, anorexigens, NSAIDs, sympathomimetics, the effect of the drug "Clofelin" weaken.

Eye drops are recommended not to be used in combination with antidepressants and antipsychotics.

Conclusion

Use any medications, including the drug "Clofelin", only after consulting a doctor. To diagnose, to select an effective therapy can only an experienced specialist. To avoid unpleasant consequences, one should not self-medicate. Trust your health professionals!