The drug "Amikacin": reviews of doctors

How does a drug such as "Amikacin" (injections) work? Reviews about the effectiveness of this drug are discussed further. Also, the article presents indications for the use of this remedy, its therapeutic features and methods of application.

Form, composition

What is the form of Amicacin? The reviews report that this remedy can be purchased in the form of a transparent, slightly colored or colorless solution that is intended for intramuscular and intravenous administration.

The active element of this drug is amikacin, presented in the form of sulfate. Also in the composition of the solution are such constituent ingredients as dilute sulfuric acid, sodium disulfite, water d / and sodium citrate d / u.

The medicine in question is sold in ampoules of glass, which are packed in paper packs.

One can not help saying that the drug "Amikacin", whose reviews are more positive, can be found in the form of a powder intended for the preparation of an injection solution.

Mechanism of action

What is Amikacin? The doctors' comments say that this is a semi-synthetic antibiotic agent that belongs to the aminoglycoside group and has a bactericidal effect.

The drug in question is highly active against gram-negative aerobic microorganisms and certain types of gram-positive bacteria. It should be noted that anaerobic microorganisms show good resistance to it.

The drug "Amikacin", reviews of which all patients can leave, does not lose its activity under the influence of enzymes that inactivate other aminoglycosides, and can also detrimentally affect the strains of Pseudomonas aeruginosa, which show high resistance to gentamycin, tobramycin and netilmicin.

Kinetic capacity of the solution

Is the drug "Amikacin" absorbed? The reviews say that after intramuscular injection this drug is absorbed completely and quickly enough. At the same time, the average therapeutic concentration of the active substance of this agent is maintained for 11-12 hours.

"Amikacin" binds to plasma proteins, is fairly well distributed in extracellular fluids, is found in bronchial secretions, urine, sputum, bile, aqueous humor of visual organs, maternal milk and cerebrospinal fluid.

This drug is not metabolized. It is excreted by the kidneys unchanged.

Indications for the administration of a medicine

In what cases do you use Amikacin (injections)? Children (many patients leave comments about this remedy), and adults prescribe this medication for infectious and inflammatory diseases that were caused by gram-negative microorganisms or their associations:

• sepsis;
• Infections of the respiratory tract;
• CNS infections (including meningitis);
• Endocarditis septic;
• Infection of the abdominal cavity;
• Infections (purulent) of soft tissues and skin;
• Urinary tract infections (including cystitis, pyelonephritis, urethritis);
• Biliary tract infections;
• Wound infection;
• Infection of joints and bones;
• Postoperative infections.

Prohibitions for the introduction of

When should I not administer Amicacin? Pneumonia (reviews of the drug are listed below) this medication treats very well. However, it is forbidden to use when:

• Pregnancy;
• Neuritis of the auditory nerve ;
• Severe renal failure of a chronic type with uremia and azotemia;
• High sensitivity to drug substances;
• High sensitivity to other aminoglycosides.

With caution, this tool should be used for myasthenia gravis, dehydration, parkinsonism and botulism, kidney failure, in the elderly, during the newborn period, during lactation and in premature infants.

The drug "Amikacin": instructions

The reviews report that for the best therapeutic effectiveness the drug in question should be used only for the doctor's prescription.

This medication is administered intravenously or intramuscularly to adult patients, as well as children from six years of age.

The maximum dosage of this antibiotic for adults is 15 mg / kg per day. Duration of treatment with the drug under consideration for intravenous administration is a week, and for intramuscular administration it is 9-10 days.

As for children, the initial single dose of the drug for them is 10 mg / kg, and then - at 7.5 mg / kg every 20-24 hours.

For intravenous administration, this medication should be previously diluted with 5% dextrose solution or 0.9% sodium chloride solution.

Adverse events

When using Amikacin, such side effects as nausea, drowsiness, vomiting, headache, liver dysfunction, anemia, ototoxicity, nephrotoxicity, skin rash, soreness at the injection site, pruritus, dermatitis, skin hyperemia, phlebitis, fever may occur. , Periphlebitis, angioedema.

Reviews

The experts' comments on the Amikacin drug state that in most cases this medication is very effective. He fights well with various infections and greatly alleviates the difficult condition of patients. However, it should be noted that many doctors are concerned that the drug in question causes many side effects. In this regard, most specialists are wary of prescribing this drug and replacing it with safer analogs.