"Gordoks": the instruction on application, responses. Analogs of the drug "Gordoks"

Any medications should be used strictly according to the doctor's prescription and after careful study of the instructions. The medicine "Gordoks" is not an exception. A detailed description will be given below.

Composition of the preparation and form of release

The drug "Gordoks" is presented in the form of a solution for injection. It is an inhibitor of fibrinolysis, the main active ingredient of which is aprotinin. As auxiliary elements used benzyl alcohol, sodium chloride, as well as purified water.

The solution "Gordoks" can not be used for self-treatment and is released in pharmacies only on prescription. It is prepacked in 10 ml in transparent ampoules, which are in a cardboard box. Less often the medicament is presented in the form of a concentrate for solution preparation and has the form of a powder.

Indications

The drug "Gordoks" can be prescribed only to adults of age. Most often it is used for aortocoronary bypass surgery as a prophylaxis of hemorrhage. In addition, the drug can be prescribed for various forms of pancreatitis - acute and chronic. Often, the medication is used in surgery, when it becomes necessary to treat the pancreas. The Gordoks solution can be used during diagnostic studies to prevent the enzymatic autolysis of the pancreas.

Any surgical intervention is characterized by serious blood loss. The most dangerous in this regard are surgical operations on the prostate gland and lungs, since they are likely to cause bleeding. The blood loss on the background of hyperfibrinolysis can be controlled with the help of the drug "Gordoks." Assign it to serious injuries of the skin (burns cuts, allergic reactions).

The Gordoks solution can be given to pregnant women in the last trimester. The medicine helps to protect the woman in childbirth from serious blood loss. In addition, the risk of embolism with amniotic fluid is significantly reduced.

The drug can be used as an auxiliary for burn, toxic or traumatic shock. Apply it with angioneurotic edema of tissues. Often, the drug is prescribed after surgery as a prevention of embolism and bleeding in the lungs. With polytrauma, the solution "Gordoks" in ampoules helps to avoid fatty emboli. Especially often it is prescribed for fractures of the bones of the skull and lower limbs.

Who is not prescribed the medication "Gordoks"?

The medicine has practically no contraindications. Due to the lack of sufficient research, the medication is not prescribed to under-age patients. The safety of the use of the product by children has not been established to date. In rare cases, sensitivity to individual components of the drug may occur. If there is an individual intolerance, the Gordox solution is immediately canceled.

At pregnancy the medicine is not counter-indicative. But its use is only on the prescription of the doctor. The medicine can be used only if the potential benefit to the mother is much greater than the harm to the fetus. Those who gave birth to the medicine "Gordoks", the reviews leave mostly positive. The medicine helps to avoid large blood loss during tears.

The use of the drug in the lactation period has not been studied. Theoretically, the medicine is absolutely safe when the baby enters the body through the mother's milk. The fact is that the drug "Gordoks" with internal use of bioavailability does not.

special instructions

Aprotinin, which is the main active ingredient of the drug, is capable of causing serious allergic reactions. At primary application the by-effects almost never are shown. Caution should be used again. And before using the "Gordoks" solution, the instruction manual should be studied first. In rare cases, anaphylactic reactions may occur . Therefore, in the hospital before the introduction of the main dosage of the drug, a sample is introduced, which is 1 ml. The doctor observes the reaction of the patient for 10 minutes. If no side effects are observed, the basic norm of the drug "Gordoks" is introduced.

In rare cases, the patient may not respond to the trial dosage. And with the introduction of a therapeutic dose, serious allergic reactions are observed. In the event of any phenomena that significantly worsen the patient's health, the use of the drug "Gordoks" immediately ceases.

Applying the drug, it should be remembered that it contains benzyl alcohol. Proceeding from this, the drug "Gordoks" should be used with caution. The dosage of benzyl alcohol per day is calculated based on the patient's body weight (90 mg per 1 kg of body weight).

The solution "Gordoks" has the property of settling on the bottom of the storage tank. If the expiration date of the product has not yet ended, but a sediment has already formed, it is better not to use the drug. Before starting therapy, the drug should be subjected to a thorough visual examination.

The medicine is not contraindicated for use in old age. In rare cases, dose adjustment is necessary. Precautions are prescribed for patients with hepatic and renal insufficiency.

The drug "Gordoks" does not influence the management of the car or other complex mechanisms. But it should be noted that the medication is prescribed most often in severe cases, when the patient is in a hospital. Therefore, the need to get behind the wheel of the car initially missing.

Dosage

Medication "Gordoks" is administered only intravenously. Most often this is done with the help of dropper systems. The drug is injected slowly at 5-10 ml per minute. Only trunk veins are used, through which no other medicines should be taken. Due to the fact that patients often develop anaphylactic or allergic reactions, a test injection is made 10 minutes before the introduction of the main dose. Its volume is 1 ml. The doctor carefully monitors the patient's basic indicators. Therapy can be continued if there are no adverse reactions.

The initial dosage for the treatment of an adult patient is 100-200 ml. Enter the medicine gradually for 10-15 minutes. Further the dosage can be increased by another 200 ml. To ensure a normal dilution of the drug, the dosage should be increased only during the recirculation period. The total volume of the drug during the course of treatment should not exceed 700 ml.

In case of side effects, the dosage of the drug can be corrected. In a smaller volume, the drug is used in patients older than 60 years. Cases of drug overdose have not been previously identified.

Adverse events

In patients who first use the drug "Gordoks", side effects occur rarely. Serious allergic reactions can develop with repeated use of the drug. The most dangerous for patients is anaphylactic shock. But such an adverse event occurs only in 1% of cases. With any changes in the state of health, a doctor's consultation is required. Most often, side effects occur with the repeated use of the drug "Gordoks" for 6 months. Before applying the drug, a trial dose is mandatory.

Allergic reactions most often manifest violations of the cardiovascular system. The patient can accelerate the heart rate, increase blood pressure. From the gastrointestinal tract can be observed such unpleasant symptoms as nausea, diarrhea, vomiting. Rarely, skin rashes and itching may occur. There are violations of the respiratory system, which manifest themselves in the form of asthma or bronchospasm. At any hypersensitivity manifestations, aprotinin-based drugs are immediately withdrawn. The patient should be given immediate assistance. The stories are familiar with the cases of lethal outcome due to the use of the drug in patients with a tendency to allergic reactions.

In some cases, there may be abnormalities in the urinary system. Kidney function may be impaired . Rarely developing kidney failure. The decision to stop the use of a medicine is taken only by a doctor. If the side effects are not significant, the therapy continues. Can only be adjusted dosage.

Interaction with other medicinal products

With other drugs with caution should use the drug "Gordoks." Instruction for use describes the means with which the solution is not generally recommended. Preparations based on alteplase, urokinase, streptokinase together with aprotininom can not be taken. The problem is that the activity of all of the above components will be significantly reduced. This means that treatment will not give the desired result.

Fully compatible solution "Gordoks" only with glucose and hydroxyethyl starch. Use the medicine together with other drugs is only after consulting a doctor.

Terms and conditions of storage

Absolutely unpretentious is the medicine "Gordreks." The instruction says that it should be stored at a temperature of no higher than 30 degrees in a dry, dark place. Leaving the solution in the refrigerator is not necessary. And here from children the drug to hide nevertheless costs or stands. Any medicine is potentially dangerous for a little man. The ideal place to store the Gordoks solution is the farthest shelf in the cabinet.

The medication has a sufficiently long shelf life, which has 60 months from the date of issue. It is worth noting that the medicine is dispensed on prescription. Rarely there are cases when the solution is not consumed completely during the treatment.

«Gordoks». Drug analogues

Sometimes it is not always possible to find a drug with such a name in pharmacies. But there are drugs that have an identical pharmacological effect, and also have a similar composition. If there is no possibility to apply Gordoks solution in pancreatitis, you can use the drug "Trasilol". This drug is also manufactured on the basis of aprotinin. The medicine is used not only for pancreatitis. It is prescribed for operations or diagnostic studies on the pancreas. In addition, the drug can stop post-traumatic, as well as postoperative bleeding.

The medication is not prescribed to under-age patients, but also to people who are prone to developing allergic reactions. Caution is used in elderly patients, as well as in women during gestation. Adverse reactions during the initial use of the solution "Trisilol" are rare. If there is a need to apply the drug again for 6 months, there is a risk of anaphylactic reactions. In order to avoid any side effects before the start of therapy, a test dose is administered.

The drug "Trasilol" is released in pharmacies according to the prescription, as well as the drug "Gordoks". The use is only possible according to the doctor's prescription. All drugs based on aprotinin can be used only in a hospital.

Less commonly, you can find a drug called "Aprotex", which has completely similar properties.

The cost of the drug and its reviews

Patients who are in a difficult postoperative period, significantly helps improve the health of the drug "Gordoks." The reviews show that the medication helps to stop the bleeding more quickly. As a result, blood pressure is normalized. Negative feedback on the drug can be heard only from those patients who are hypersensitive to aprotinin. Serious allergic reactions may occur that require the withdrawal of the drug. But this does not mean that Gordoks is ineffective. Instructions for use say that a test injection should be performed before starting therapy.

Effective, according to doctors, with pancreatitis is a solution of "Gordoks." Analogues for the treatment of ailment can also be used. But they are more often more expensive. Cheap drug "Gordoks" can not be named. The cost of it in some pharmacies is about 10,000 rubles. And this is just one 10 ml package. The maximum dosage can be 700 ml per course. It is easy to calculate how much treatment will cost. This is perhaps the biggest disadvantage, which repels patients from the drug. But in some cases, you do not have to choose. The use of the drug "Gordoks" is vital.

Acceptance of any medications should be agreed with the doctor. Before using Gordox, the instructions for use should be carefully studied. Negative reviews occur only in those who engage in self-medication. After all, the solution may be incompatible with certain medicines. Such treatment will not only fail to produce positive results, but can also be dangerous to health.