The drug "Acyclovir-AKOS" (pills). Instructions for use for children and adults, reviews

In what dose do you prescribe the medicine "Acyclovir-Acos"? Instructions for the use of these tablets will be presented below. Also, you will find out about what this remedy is used for, whether it has side effects and contraindications, what is included in its composition, and in what packaging it is put on sale.

Composition, description, packaging of medicinal product

What components does Acyclovir-Acos (tablets) contain? Instructions for use say that the active ingredient in this medication is acyclovir. It also includes additional ingredients in the form of talc, magnesium stearate and potato starch.

"Acyclovir-Acos" - tablets (patient reviews will be described below) flat-cylindrical white with a risk and facet. In the sale of the drug comes in contour cells, which are placed in cardboard packages. Also, this medicine can be found in banks of dark glass.

Pharmacological properties of the medicinal product

How does "Acyclovir-Acos" (tablets) work? Instructions for use say that this antigipertic antiviral. This preparation is a synthetic analogue of purine nucleoside. It is able to inhibit the replication of viruses of herpes simplex, cytomegalovirus, as well as Epstein-Barr viruses and Varicella zoster.

Features of the drug

According to specialists, "Acyclovir-Agos", whose reviews are more positive, shows good activity against viruses that cause shingles and chicken pox.

After taking the medication in infected cells, phosphorylation begins. Acyclovir is converted to acyclovir monophosphate. Under the influence of guanylate cyclase, the latter turns into a diphosphate, which, in turn, is converted to triphosphate.

The selective effect of the drug on viruses, as well as its low toxicity for the body, are due to the fact that its active substance does not represent a substrate for the enzyme thymidine kinase. In this regard, it is not toxic to mammalian cells.

After the conversion of acyclovir to acyclovir triphosphate, it inhibits the synthesis of DNA from virus 3 by mechanisms:

• Replaces deoxyguanosine triphosphate;
• Is inserted into the DNA chain, and then stops its elongation;
• Oppressively affects the DNA of herpes simplex, etc.

As a result of this effect, the reproduction of the virus stops.

The effectiveness of acyclovir is also due to its accumulation in cells that are already infected with the virus. With herpes, the drug prevents the formation of new rashes, as well as accelerates wound healing, reduces pain and has an immunostimulating effect.

Pharmacokinetic indices of antiherpetic tablets

Where is the absorption of the drug "Acyclovir-Acos"? Instruction for use reports that after ingestion, it is absorbed in small amounts from the intestine. At the same time, concentrations (dose-dependent) are formed, which are quite sufficient for the effective treatment of viral diseases.

Food has virtually no effect on the absorption of the active substance. As the dose is increased, the bioavailability of the medicament decreases.

The maximum concentration of the drug after its administration in an amount of 200 mg 5 times a day is 0.75 μg / ml, and the minimum concentration is 0.45 μg / ml. These values are noted after two hours.

With plasma proteins, the active substance binds to 10-35%. It penetrates the blood-brain barrier, as well as practically all tissues and organs (lungs, brain, lacrimal fluid, kidneys, intestines, liver, muscles, watery moisture, breast milk, semen, spleen, amniotic fluid, uterus, secret and mucous membrane Vagina, and also in the contents of herpetic vesicles).

The drug is metabolized in the liver. A metabolite, called 9-carboxymethoxymethyl guanine, is formed.

Drug is withdrawn through the kidneys (62-91% of the dose) and through the digestive tract. Also, trace amounts of medication are determined in the air exhaled by the patient.

When taking the drug inside its half-life (in adult people) is - 3.4 hours, and in children (1-18 years) - 2.4 hours. Thus, it can be safely noted that the rate of excretion of the drug slows down with age.

Indications for use of the drug

When do they designate Acyclovir-Acos? The use of this drug is indicated for the prevention and treatment of infections that are caused by the viruses Varicella zoster and Herpes simplex (2 and 1 types). Thus, this medication effectively fights against:

• Simple herpes on the skin and mucous membranes (recurrent and primary);
• Shingles;
• Genital herpes (primary and recurrent);
• Herpes zoster;
• Chicken pox (the first day after the appearance of the rash).

It should also be noted that this drug is actively prescribed to patients with severe immunodeficiency (for example, in HIV-infected people, after transplantation and during the reception of immunosuppressive medications).

Contraindications for use

In what cases is it forbidden to apply "Acyclovir-Acos" (tablets)? The instruction indicates the following contraindications:

• Children's age (up to three years);
• Hypersensitivity to the active substance, as well as to valaciclovir.

With special care, this medication is prescribed for pregnancy, kidney failure and dehydration, as well as during breastfeeding.

The drug "Acyclovir-Acos": how to take adult people?

Tablets should be taken orally, regardless of food, with a glass of plain water.

Adults for the treatment of herpes simplex on the mucous membranes and skin appoint 200 mg of the drug five times a day. Take the medicine every four hours (except for sleep).

Typically, the duration of therapy with such a drug is five days. But if necessary, it can be prolonged (according to the doctor's recommendations).

In the treatment of people with immunodeficiency, a single dosage of the drug is increased to 400 mg, and the duration of the course is up to ten days or more.

Adult patients with genital herpes are recommended to take 200 mg of the drug five times a day (every four hours) for 10 days (if necessary, therapy can be extended). Treatment should be started as soon as possible after the first signs of infection. If there are relapses, the drug is prescribed already in the prodromal period.

To prevent the recurrence of infections that were caused by the herpes simplex virus, the medication is prescribed at 200 mg four times a day (every six hours). People with normal immunity can use the drug in the amount of 400 mg twice a day (every 12 hours). If the immunodeficiency is expressed, the dosage remains the same, but the frequency is increased up to five times a day.

Genital herpes relapsing (less than six times a year) requires the following treatment regimen: 200 mg five times a day for five days. If the episodes are repeated more than six times a year, then the patient is prescribed 400 mg twice a day for 12 months. The duration of prevention is usually determined by the duration of the period when there is a risk of infection.

When treating herpes zoster or depriving the patient, 800 mg of the drug is prescribed five times a day (every four hours) for 7-10 days.

The maximum single dose of this medication is 800 mg.

People taking high doses of the drug should receive a large amount of fluid.

"Acyclovir-Acos" (tablets): instruction for children

Babies, whose age has reached three years, this medication should be prescribed only by experienced pediatricians. Typically, dosages for them are similar to those for adults.

To treat chicken pox, children over six years of age are given 800 mg of the drug four times a day, and a child aged 3-6 years - 400 mg four times a day. For more accurate dosage, doctors use the following formula: 20 mg per kg of baby's weight. Take medication more than 800 mg four times a day is prohibited.

The duration of therapy in small patients is five days.

People with impaired renal function require dose adjustment, as well as frequency of admission. It depends on the type of infection and the amount of creatinine clearance.

Side effects after taking pills

The drug "Acyclovir-Acos" very rarely causes side effects. But, according to the instruction, they still have a place to be.

1. Nausea, increased bilirubin, diarrhea, abdominal pain, vomiting, reversible increase in the level of activity of liver enzymes.
2. Acute renal failure, increased levels of creatinine in the blood and urea.
3. Leukopenia, anemia, thrombocytopenia.
4. Headache, hallucinations, neurological disorders reversible, confusion, dizziness, paresthesia, drowsiness, coma, convulsions.
5. Rash, dyspnea, photosensitivity, angioedema edema, urticaria, fever, pruritus, lymphadenopathy, anaphylaxis, agitation, visual impairment, peripheral edema, myalgia.
6. Rapid fatigue, alopecia.

It should also be noted that in people who receive antiretroviral drugs, the additional intake of the drug "Acyclovir-Acos" does not cause a significant increase in toxic effects.

Special recommendations on the use of antiherpetic drugs

What should I know before taking Acyclovir-Acos (pills)? The instruction says that prolonged or repeated treatment of people with a decreased immune status can lead to the formation of strains of viruses that are insensitive to its action.

Clinical studies on the safety of the use of this medication during pregnancy have not been conducted. In this regard, the use of the drug "Acyclovir-Acos" is shown only in those cases when the possible benefit to the mother significantly exceeds the possible risk to the fetus.

In the process of treatment with high oral dosages, the patient must drink a sufficient amount of water.

During breastfeeding, medication is prescribed only in extreme cases and a short course. This is due to the fact that the drug in small amounts penetrates into breast milk.

The drug "Acyclovir-Acos" does not prevent the transmission of herpes by sexual route. Therefore, during the treatment period, the patient should refrain from sexual intercourse.

Patients' comments about the drug

Now you know how and for what purpose the drug "Acyclovir-Acos" is prescribed. Instructions for use of this tool have been described in detail above.

According to reviews of most patients, the drug in question effectively manifests itself in herpetic rashes. If you take the pill immediately after finding the first signs of herpes, then the patient's recovery comes much faster.

It should also be noted that "Acyclovir-Akos" effectively cures shingles and chicken pox.

In addition to therapy, this medication is often used as a preventive agent. Its correct reception helps to reduce the number of relapses to a minimum.

Price of medicinal product

It should also be said that in addition to high efficiency, the drug "Acyclovir-Acos" pleases patients and its rather low cost. You can buy 20 antiherpetic tablets for 30-40 Russian rubles. This amount is enough for the whole course of treatment.

By the way, analogues of this medicine possess the same low price.