The best analogue of "Kordaron" in Russia

Treatment of heart rhythm disturbances is a complex medical problem that is not solved until the end even today. There are many antiarrhythmic drugs, but all of them have a lot of contraindications and side effects, because of what can be a patient much more dangerous than ailment. There are whole groups of drugs intended for arresting arrhythmias, life-threatening, but their use for a long time is not recommended because of the increase arising from the medication complications. Accordingly, patients need a reliable, effective, but relatively safe drug or its analogue.

"Cordarone" - effective antiarrhythmic medicine

According to various studies, "Cordarone" is the most effective drug from other similar drugs, has a proven ability to reduce mortality in individuals with cardiac pathology. It is successfully used to treat almost all cardiac arrhythmias. Among physicians, he is considered the standard among antiarrhythmic drugs of the third class. In addition to antiarrhythmic, it has an antianginal effect, since it was first developed as a drug for the treatment of coronary heart disease.

It has not only the action characteristic of antiarrhythmics of the third class, that is, the blockade of the potassium channels, but also the action characteristic of the first class drugs, the blockade of the sodium channels, the IV class, the blockade of the calcium channels. Among other things, the drug gives an alpha and beta-adrenoblocking, coronary-extending effect.

Indications for use

The active substance of the drug is amiodarone. The trade name is Kordaron. Analogues are produced under different names, but contain the same active substance. Amiodarone is available in the form of a solution for intravenous administration and tablets.

The solution is used in cases when it is necessary to stop attacks of ventricular and supraventricular tachycardia, atrial fibrillation, including seizures. Tablets are used to prevent ventricular and atrial fibrillation and paroxysmal tachycardia.

Operating principle

Suppressing the process of intracellular transport of potassium ions, the drug extends the third phase of the cardiac muscle cell action potential . This also suppresses the transfer of the electric pulse in the fibers of the atrioventricular node. Because of this, the pulse slows down. As a result of partial blocking of the influence of the sympathetic nervous system, the heart rate is slowed down.

Amiodarone is metabolized in the liver, excreted mainly with urine. The maximum content of active substance is noted in 3-7 hours after taking the tablet. A strong therapeutic effect manifests itself not earlier than a week after the start of treatment.

Analogues of "Kordaron"

In many cases, patients for a number of reasons prefer not the original drug, but its analogs, generics. Since "Kordaron" is just the trade name of amiodarone, those suffering from arrhythmias are often interested in whether there are analogues of "Cordarone" medication.

As for amiodarone, the question of its analogues is of particular relevance, because it is one of the most popular cardiological drugs in the world, which has wide application. Similar drugs, as mentioned above, have a lot of side effects, often worsening health. Therefore, both the doctor and the patient are interested in choosing the drug with maximum efficiency and minimum risk for health and life. If you are looking for equivalents analogous to Cordarone, medical reviews in this case should be crucial for you, although, of course, patient feedback is also important, as they can tell you about the sensations during admission and the speed of improvement. In this case, treatment with both "Cordarone" and any of the analogs should be accompanied by medical monitoring and monitoring of the health status, including with the help of ECG.

An important role played by the composition of the drug. For example, iodine, which is part of amiodarone, is contraindicated in a number of diseases. It can also distort the results of some studies. Therefore it is not surprising that many suffering from arrhythmia are looking for an analogue of "Cordarone" without iodine like "Dronedaron". Of course, you can replace any drugs only after consulting a doctor. So, many Russian experts do not recommend without the need to choose "Dronedaron", as this is a weaker analogue of "Kordaron". In Europe, however, it is already quite common.

When choosing a drug or an analogue, you need to compare their composition. As a general rule, analogues and generics are not compared with each other - only with the original. For example, if you need an analog of "Cordarone" in ampoules, then benzyl alcohol should be present in the composition of a similar solution for injections, as in the original "Kordarone".

According to physicians, the analogues in Russia are not inferior in the properties of the drug "Kordaron" in Russia are represented by quite a large number of drugs, including: Rhythmiodarone, Sedacoron, Amiocordin, Cardiodarone, Rhythmorest, "Amiodarone" from various manufacturers ("Amiodaron-Acry", "Vero-Amiodarone" and many others). They all have the same active substance, but they can have different auxiliary substances. Many of them are much cheaper than the original. In most cases, this factor depends on the manufacturer. For example, "Amiodarone", which is called the same as the main substance contained in the drug "Kordaron." The analogue is Russian, and its price is almost three times lower, although the form of the issue and the indication for the appointment coincide.

"Amiodoron" is the best analogue in Russia. It is practically indistinguishable from "Kordaron" and by the principle of action, and by the method of application, it has the same high effectiveness in stopping arrhythmia attacks and preventing their occurrence. The patient's comments about him are mostly positive. Many of them note that "Amiodoron" of Russian production helps quickly and without heavy pobochki.

Method of application in ampoules

As mentioned above, injection solution is indicated for rapid relief of the problem. In the remaining cases, Kordaron tablets are used. Analogues act in the same way. Solutions are injected intravenously through the catheter for 20-120 minutes or in jet for at least 3 minutes at a dosage of 5 mg per 1 kg of body weight.

Method of application of tableted "Cordarone"

The drug in tablets is taken in two stages.

The first stage, or the loading phase: 600-800 mg once a day with an increase to 10 g.

The second stage, or the supporting phase: 100-400 mg of the drug (duration is determined by the doctor). The maximum dose is 1200 mg per day.

Overdosing of the drug is quite dangerous. In order not to admit it, the patient is recommended to know most precisely how the instructions for use are recommended for taking Cordarone. Analogues, including the popular analogue in Russia "Amiadaron", mostly give the same symptoms of an overdose.

There is a strong bradycardia, even up to cardiac arrest. If it is caused by a tablet form, it is necessary to rinse the stomach and take enterosorbents. Other symptomatic treatment is also performed, electrolyte balance is corrected. If necessary, a pacemaker is installed.

About overdose intravenously, the information is incomplete. Rare cases of sinus bradycardia, tachycardia, and cardiac arrest are described. Treatment is similar to what is prescribed for an overdose caused by pills. When hemodialysis, amiodarone and its metabolites are not removed.

Side effects

Like any effective remedy with a powerful effect, "Kordaron", "Amiodarone" and other analogues provoke a number of side effects. They cause a bradycardia, up to a cardiac arrest, a decrease in blood pressure, have a negative effect on the liver, and therefore have a fairly impressive list of contraindications.

Of the less severe, but nevertheless unpleasant side effects can be noted headache and dizziness, pleurisy, cough, the patient can complain of weakness, reduced visual acuity. There may be allergic reactions. The same problems can be obtained by taking any analogue. "Cordarone" and other drugs amiodarone in tablets for this reason are sold in pharmacies only on the prescription of a doctor. The solution for injections is used only in a hospital.

However, with precautions when choosing the maximum dose, side effects are not very pronounced or may not manifest at all. As noted in the reviews of "Cordarone" and "Amiodarone" patients who take these drugs, pobochka is usually weak, it is easy to eliminate the dose adjustment.

Contraindications

Since amiodarone is a fairly strong drug, it is not surprising that it not only can improve the condition in a number of cardiological problems, but it also has a destructive effect on other organs or worsens the condition with certain concomitant diseases. To avoid risk, therapy with this drug is not recommended in a number of cases.

There is a whole range of conditions in which it is forbidden to take Cordarone, Amiodarone and other analogues in tablets. First of all, these are some pathological cardiac conditions - sinus bradycardia, severe atrioventricular blockade, arterial hypotension, prolongation of the QT interval on a cardiogram. It can not be used if the patient has a lower content of magnesium and potassium in the body.

Contraindications include thyroid pathologies, as well as pregnancy and the period of breastfeeding - the reason in iodine, which contains the drug "Cordarone". An analogue that does not contain it can be taken only on the advice of a doctor.

Patients in old age are advised with caution to take as "Kordaron", and "Amiodarone" and other analogues. Patients under 18 years of age are not prescribed these medicines.

It is not recommended to prescribe this remedy for those who suffer from bronchial asthma, respiratory insufficiency, has severe heart failure. Heavy pathology of the liver and kidneys is also an excuse to refuse treatment by this method.

Undoubtedly, do not take the medicine if there is an individual intolerance to the components of the drug "Kordaron." Analogues in Russia and another European country have the same composition, so in this case, replace one tool with another is unlikely to work.

As for injections, they should not be given to babies under 3 years, for children over 3 years of age, the dose should not exceed 5 mg / kg. Do not mix the drug in one syringe with other medicines. In general, contraindications to the solution are similar to the contraindications to tablets. This sinus bradycardia, sinus node weakness syndrome and severe conduction disorders, as well as sinoatrial blockade of the heart and paroxysmal ventricular tachycardia. In particular, such phenomena are possible with the administration of amiodarone in combination with a number of other drugs.

Prescribe injections during pregnancy is possible only in exceptional cases, with lactation, this method of treatment is completely excluded. It is impossible to conduct therapy with the use of a solution of "Cordarone" with dysfunctions of the thyroid gland, allergic reactions to iodine or amiodarone.

Interaction with other drugs

"Cordarone" can be combined with other drugs. Thus, its antianginal effect is enhanced in combination with long-acting nitrate preparations. It can be used in conjunction with anticoagulants, diuretics, cardiotonic drugs, do not interact and, accordingly, do not weaken and intensify each other's "Cordarone" and some neuroleptics, analgesics, hypnotics and sedatives. Almost the same reaction to these drugs any analog.

"Cordarone" can not be used simultaneously with MAO inhibitors and beta-blockers (only in exceptional cases).

Precautions for the treatment of "Cordarone" and "Amiodarone"

During the reception of these funds, it is necessary to monitor the state of the body before the start of treatment, during and after it.

Before and during therapy with the tablet form, an ECG is recommended. The action of the drug causes changes in the electrocardiogram, in particular, the prolongation of the Q-T and Q-Tc interval. Based on the results of the examination, the doctor can adjust the dosage and determine the effectiveness of treatment.

Treatment stops if the atrioventricular block of II and III degree develops, sinoatrial, two-beam intraventricular.

Since one of the components of the drug is iodine, regular monitoring of the functions of the thyroid gland is necessary. Before treatment it is required to determine the levels of hormones T3, T4 and TSH. Please note that against the background of the "Cordarone" reception, the results of the radioisotope study of the thyroid gland may be unreliable. Iodine levels are not affected by hormone levels.

Another important factor is the determination of serum potassium levels before and during treatment.

When introducing "Cordarone" intravenously, only infusions are recommended, and not injections with a syringe. Otherwise, it is possible to develop hemodynamic disorders - arterial hypotension, acute cardiovascular insufficiency. You can inject the drug with a syringe only in exceptional emergency situations and in the absence of other possibilities. In this case, the dose is 5 mg / kg and is administered within three minutes, repeatedly - not earlier than 15 minutes after the first administration of the drug. The procedure can be performed only in cardiac recovery units under ECG monitoring. "Cordarone" is not allowed to mix in a syringe with other drugs. If long-term treatment is required, it is required to switch to infusion. Any intravenous injection of amiodarone is carried out in hospitals.

If the patient is to have a general anesthesia, the anesthetist should be informed that the drug is being taken.

To avoid side effects, patients must comply with the prescribed dosage.

During treatment, patients should avoid sunlight and, if necessary, use protection from it (including special creams).

Be sure to consult with your doctor if, for some reason, plan to take not "Cordarone", but its analog. "Cordarone" and similar drugs, like any other cardiac drugs, can be extremely dangerous with an uncontrolled admission. Only the doctor can determine which of the medicines will be best in your case and will choose a safe but effective dosage.