"Aklasta": reviews, instructions for use, analogues

More and more problems are caused today by many attempts to improve their health. Elderly age, an abundance of stresses, existing chronic diseases have an extremely negative effect on the general condition of the human body and cause the emergence of more and more new diseases. Particularly serious are problems with the musculoskeletal system. The overwhelming majority of patients simply do not have in their bodies enough mineral resources so that they can cope with the difficulty on their own. That is why such conditions associated with the destruction of bone tissue are often only aggravated with time.

Fortunately, modern medicine has found a number of opportunities to improve the quality of life of such patients. Developed even drugs that need to be introduced only once a year. The effect of such medications is enough to feel good right up to the next procedure. One of such drugs is "Aklasta". Many have already had time to evaluate the whole spectrum of its action. It is important that the potential patient has studied all available information about the drug "Aklasta": instructions for use, reviews, analogues. This will allow him to make sure of its effectiveness, to assess all the attendant risks and inconveniences and to make his own informed decision as to whether it is worth using the drug in question.

Indications for use

In what cases would it be reasonable to use the drug "Aklasta"? The instruction, the reviews report that the drug under consideration is effective in the following situations:

• The prevention of the occurrence of new fractures in those patients who already suffer a fracture of the femur (namely, its proximal part);
• Paget's disease (osseous);
• The development of osteoporosis (in particular, in male patients);
• Prevention of development in female patients suffering from osteopenia, postmenopausal osteoporosis;
• Directly postmenopausal osteoporosis (the drug provides a significant reduction in the risk of severe fractures, fractures of the femur, as well as individual vertebrae and even out-vertebral fractures, the drug significantly increases bone mineral density);
• It is used for the prevention, as well as the actual treatment of osteoporosis, which has developed under the influence of the use of glucocorticosteroids.

Contraindications

Can everyone use the drug Aklast? The doctors' comments tell us that the medication in question has a number of serious contraindications. Among them, the following are particularly distinguished:

• Period of bearing of the child;
• High personal sensitivity to zoledronic acid, as well as other individual components of the drug;
• The period of breastfeeding of the child;
• Any violations in the process of the implementation of mineral metabolism (the most common disorder is hypocalcemia);
• Inappropriate age of the patient (safety and efficacy of the drug in question for juvenile patients was not proven);
• Disorders in the functioning of the kidneys (of varying severity).

In the presence of at least one of the above conditions it is important not to start using the drug "Aklast." Reviews (who took the drug, can tell from personal experience) report that the use of this drug by a patient who has contraindications, can lead to acute deterioration of the condition. The replacement must be selected by a competent specialist.

Mode of application

How should the drug be used? It is administered intravenously. For this, a valve infusion system is used that provides a permanent infusion rate. The procedure takes fifteen minutes. It is important that the patient, at some time before the start of treatment, begins to consume enough clean drinking water.

So, to fight postmenopausal female osteoporosis and male osteoporosis, a working dose of the drug is prescribed - five milligrams (while one bottle, as a rule, contains one hundred milliliters). The procedure is carried out only once a year. Sometimes the attending physician considers it necessary to additionally prescribe the intake of calcium and vitamin D. The same working dose is prescribed to prevent the occurrence of repeated fractures, and to compact the bones in the postoperative period, and to combat the bone disease of Paget.

Those patients who suffer from a dysfunction of the kidneys or liver do not need to be personally reviewed for the originally assigned working doses of the drug. Similarly, the situation develops with elderly patients (whose age, in particular, exceeds 65 years). Age does not play a significant role in how the drug works in the body, as well as in how it is distributed and exported.

When using this drug, it is important to comply with all existing aseptic standards. What does this mean? It is necessary before you start the introduction of the drug, carefully consider the contents of the vial and assess how much the quality and color of the solution match the claimed. If you notice a change in color or a precipitate, do not use this product. "Aklastu" is administered separately from all other drugs. It can not be mixed with other agents and even allows minimal contact of the drug with substances that contain calcium.

It is important to use the drug immediately after the vial in which it was released has been opened. If some part of the solution still fails to be applied immediately, it should be kept in the refrigerator, but not longer than one day. The acceptable storage temperature is from two to eight degrees. Before use, such a solution is important to warm up, bringing to room temperature. It is necessary to give him the opportunity to independently reach the ambient temperature.

Side effects

Sometimes there may be some unpleasant effects from using the drug "Aklasta". Comments and doctors talk about the following possible side effects:

• Hypomagnesemia;
• stomatitis;
• Hypophosphatemia;
• nausea;
• dyspepsia;
• Hypocalcemia;
• Vomiting;
• tremor;
• Pain in the eyes;
• abdominal pain;
• Hyperkalemia;
• Decreased appetite;
• headache;
• Irit;
• Paresthesia;
• dizziness;
• Hypokalemia;
• Esophagitis;
• drowsiness;
• conjunctivitis;
• constipation;
• Hypernatremia;
• anemia;
• Bradycardia;
• Uveitis;
• diarrhea;
• Sleep disorders;
• Vertigo;
• Hematuria;
• Thrombocytopenia;
• dyspnea;
• lethargy;
• Hypoesthesia;
• anxiety;
• Acute renal insufficiency;
• fainting;
• Leukopenia;
• toothache;
• Itching;
• shiver;
• Pancytopenia;
• fever;
• Hyperesthesia;
• Muscle cramps;
• Dryness of mucous membranes in the oral cavity;
• skin rash;
• Impaired renal function;
• Swelling of the joints;
• Angioedema;
• weakness;
• cough;
• A significant increase in body weight;
• Feeling of thirst;
• Chronic fatigue syndrome;
• Confusion;
• Episcleritis;
• arthralgia;
• Pain in the chest;
• Proteinuria;
• Osteonecrosis;
• The appearance of flu symptoms;
• A disturbance of the sense of taste;
• Ossalgia;
• Peripheral edema;
• Decreased visual acuity;
• asthenia;
• Myalgia;
• Increased sweating;
• anorexia;
• Hypercreatininaemia;
• Pain in the back and limbs.

If any of these symptoms appear, stop taking the drug immediately and seek help from your doctor. The specialist will choose a suitable replacement for the drug "Aklast". The doctors' comments emphasize the importance of this step. Such a simple procedure can help to maintain health.

Overdose

To date, there is insufficient data on cases of overdose during treatment with the drug "Aklasta". Patients' reviews report that they were advised to be constantly monitored by a specialist if a medication dose above the medication was prescribed.

What are the symptoms of an overdose? Among them are the following:

• Hypophosphatemia;
• Acute renal insufficiency;
• Hypomagnesemia;
• Hypocalcemia.

How is it recommended to get rid of the symptoms of overdose that occurred during the application of the drug "Aklasta"? The doctor's advice is to inject intravenously certain solutions that can help restore a good physical condition, for example a solution with magnesium, calcium, and phosphate ions. This procedure can sometimes save the life of a patient, so only a specialist should implement it.

Interaction with other drugs

Unfortunately, to date, there have not been enough authoritative studies that would help conclude that it is safe to use the drug "Aklasta" in parallel with other drugs. Comments are advised to pay attention to what reactions the main active ingredient, zoledronic acid, can enter. It, as is known, is not subjected to general systemic metabolism. The substance leaves the body through the kidneys. Therefore, it is important not to allow the simultaneous use of drugs that can directly or indirectly inhibit the function of these organs, as well as those that provoke active removal of fluid from the body (in particular, with diuretics).

special instructions

Experts should inform the specialists about the main nuances of the use of the medicinal product under consideration even before the beginning of therapy. For example, it is necessary to inform, how much actively promotes the excretion of calcium from the body prick "Aklasta". Reviews tell us about the emerging manifestations of hypocalcemia. That is why those patients who are at risk should be constantly monitored by a specialist.

Patients suffering from Paget's bone disease should undergo therapy only under the guidance of a competent doctor who already has considerable experience in the treatment of this disease.

Many specialists insist on the use of ibuprofen or paracetamol immediately after the administration of the drug in question. This will help reduce the unpleasant feelings that occur in the first three days after the infusion, as reported by the patient "Aklasta" reviews patients.

The injections of "Zometa" (an anticancer drug), the main active substance of which is also zolendronic acid, are not a substitute for the drug in question. They should not be used in parallel. If the patient has been diagnosed with hypocalcemia, then before starting treatment with the drug in question, additional treatment should be performed by the prescribed doctor dosages of vitamin D, as well as calcium. Similarly, it is important to adjust other available conditions characterized by disturbances in mineral metabolism.

Caution should be given to those patients who already have significant disruptions in kidney function.

It is important to take into account that there is no reliable information on the extent to which the drug in question has a significant effect on a patient's ability to manage a variety of mechanisms that are dangerous, as well as vehicles. However, judging by the occurrence of any side effects that is potentially possible (including retardation of reactions, temporary blurred vision), it is important to perform the above described actions with extreme caution.

The drug "Aklasta": reviews of patients

As a rule, those who have already personally checked the effect of the drug in question express their positive emotions from such therapy. They call the drug effective. They are told not only about the successful fight against osteoporosis and excellent splicing of bones, but even about the improvement of the condition with fractures of the neck of the hip elderly patients. And this result helps to achieve not every means.

However, there are not so positive about the drug "Aklast" reviews of patients. Side effects are quite often manifested. Among them, the most common are: high fever, aches and pains in muscles and bones, chills. However, patients with confidence declare: in spite of everything, it is necessary to use the drug in question. It will help to solve a number of serious problems with the musculoskeletal system. As a whole, the patient's remarks about the drug "Aklasta" are positive.

Analogues

The original Swiss remedy has a positive effect on bone tissue, but its cost corresponds to its effect. Therefore, not every patient, unfortunately, can afford treatment with the drug in question. As a consequence, many people prefer analogous to the drug "Aklasta". Reviews highlight a number of substitute drugs. Among them - "Belklasta", "Zometa", "Resorb" and "Resoclastin FS". Most of them are less likely to cause unpleasant consequences, as reported by the patient "Aklasta" reviews patients. Side effects when they are used are not so often. Only the attending physician can choose a substitute drug, self-medication can lead to a worsening of the condition.

Storage conditions

How would it be right to store the drug Aklasta? Instructions for use, the reviews recommend that you keep this medication in a place where the temperature does not exceed twenty-five degrees. Once opened, the vial can be stored chilled for no more than twenty-four hours. All these measures are necessary to ensure that the medicine remains effective.

Shelf life

So, for how long after manufacturing can you use the drug "Aklasta"? Comments and specialists do not recommend using the device in question three years after its production. After the end of this period, the medicament loses its useful properties and can cause some damage to the patient's health condition.

Conclusion

The drug "Aklast" - an effective drug that allows you to significantly alleviate the condition of patients suffering from problems that are caused by a decrease in bone density. It is used for Paget's disease, for the prevention of repeated fractures, as well as for combating osteoporosis of various genesis. It is important that the appointment of the drug is carried out only by a competent specialist. The peculiarities of its application are such that only the employee of the medical institution can implement the procedure of introduction. This, among other things, reduces the risk of patient self-medication. It is especially important to take this moment into account, taking into account how serious adverse reactions can occur due to improper use of the drug in question. It is necessary to carefully follow all the recommendations of the attending physician, which he will provide regarding the conduct of therapy. Find out more about the drug "Aklasta" (instructions for use, reviews). In this case, the injections of this remedy not only do not harm, but will also bring the expected benefit.

Be careful when choosing the appropriate method of treatment. Do not be lazy to spend some time researching information about it. This will help you choose the best drug available to you and significantly improve your health.

Take care of yourself and your loved ones. Choose quality. And always be healthy!