Tablets from the pressure "Physiotenses": reviews of patients and doctors

An effective antihypertensive drug, a selective imidazoline receptor agonist, is the Physiotens medication. The patients' comments say that the remedy helps to reduce the pressure on diabetics and people with increased body weight.

Features of hypertension

Diseases of the heart and blood vessels are affected by many people. However, in women these deviations develop later than in men. But they are much more complicated and characterized by high blood pressure, more pronounced painful symptoms. Hypertension often develops along with other pathologies: obesity, diabetes, abnormalities in liver and kidney function, failure of lipid metabolism.

Together with the increase in body weight, the SNS is disrupted, which is the main cause of hypertension and hypertension. The hormones released by the symptomatic nervous system contribute to the narrowing of the lumen of the vessels, as a result the heart has to push blood to the tissues and organs with blood pressure, thus developing hypertension, which must be treated with a medicamentous method. One of the drugs that can curb increased blood pressure is the Physiotens.

Composition and form of release

The drug is produced in the form of film-coated tablets. The main active ingredient is moxonindin. The auxiliary components include magnesium stearate, crospovidone, povidone, lactose monohydrate.

Pharmacological properties

The active substance of the drug has a central hypotensive effect. Moxonidine in the brain stem cells selectively stimulates sensory receptors that participate in the reflex and tonic regulation of the nervous symptomatic system. As a result, peripheral symptomatic activity and blood pressure decrease. Numerous studies (placebo-controlled, randomized, double-blind) prove the effectiveness of the drug "Physiotenses". The patients' testimonies confirm that the medication differs from other antihypertensive sympatholytic agents in that it does not cause dry mouth, with its use there is no sedative effect.

Pharmacodynamics and pharmacokinetics

After internal administration, the drug is absorbed 90% from the gastrointestinal system. The maximum concentration of active substance in the blood plasma is observed in an hour. The intake of food on the pharmacokinetics of moxonidine has no effect.

The main metabolite of the active substance is dehydrogenated moxonidine, as well as guanidine derivatives. The half-life of moxonidine occurs within 2.5 hours, and a day later the element is 90% excreted by the kidneys and through the intestine.

In patients with hypertension, in comparison with healthy people, there was no change in the pharmacokinetics of moxonidine. Slightly kinetic parameters may change in elderly patients, which is associated with a decrease in the intensity of metabolism of moxodinin, as well as its higher bioavailability. Due to the lack of pharmacokinetic studies, the use of medication is not recommended for patients before adulthood.

The drug "Physiotenses" instructions for use

Patients' comments say that the pill should be taken orally, regardless of eating. Usually the drug is used in the initial daily dosage of 200 μg. The maximum single dose of the drug should not exceed 400 mcg, the daily amount divided into two doses is 600 mcg. Patients with an average and severe degree of heart failure who are on hemodialysis, it is recommended to take up to 200 μg of funds per day. With good tolerability, the amount of the drug can be doubled.

Overdose

If you overuse the drug, you may experience various negative symptoms. So, pills from the pressure of "Physiotenses" (reviews indicate this) can provoke headache, drowsiness, sedation. When the dosage is exceeded, the pressure may drop significantly, pain in the epigastric region develops, dry mouth, bradycardia, vomiting, asthenia, increased fatigue, dizziness. In addition, patients may be disturbed by hyperglycemia, tachycardia, and a brief increase in pressure.

To treat signs of overdose, specific antidotes have not been developed. With arterial hypotension, it is necessary to introduce dopamine and increase the fluid content in the body. Symptoms of bradycardia can be stopped with atropine. In case of an overdose, reduce or eliminate arterial paradoxical hypertension is recommended by the use of antagonists of alpha-adrenergic receptors.

Drug Interactions

The combination of medicines is not always given due importance. However, with the intake of two or more drugs, there may be a weakening or intensification of the mutual action. In the first case, the medicine will not give the expected result, in the second situation there is a risk of getting an overdose and even poisoning.

Thus, with the combined use of antihypertensive agents (thiazide diuretics, calcium slow-channel blockers) with the Physiotens medication (reviews warn about this), an antihypertensive additive effect may develop. Simultaneous reception of tricyclic antidepressants lowers the effectiveness of central anti-hypertensive medications, so they should not be taken with the Physiotens medication.

In addition, the tool allows to improve cognitive impaired functions in patients taking the drug "Lorazepam". The use together with benzodiazepines can cause an increase in sedation. In the appointment with drugs "Digoxin", "Glibenclamide", "Hydrochlorothiazide" pharmacokinetic interaction is absent.

Use during pregnancy

Various drugs have a negative effect on the fetus or embryo, leading in some cases to malformations of the child. Also, the ingredients of medicines taken with human milk are able to enter the infant and act on it. Therefore, during pregnancy and lactation, it is necessary to take medication with increased caution.

Not an exception - and the drug "Physiotenses". His admission is permissible only after consulting a specialist, carefully weighing the possible benefits for the mother and harm to the child. Since the active ingredient enters the breast milk, during infant feeding it is necessary to abandon its use or stop feeding the baby.

Experimental studies conducted on animals, direct or indirect effects of the drug on pregnancy, embryonic (embryonic) or postnatal development have not been revealed.

Side effect

Like most medications, the "Physiotens" tablets (reviews testify to this) cause negative reactions from the body. This usually occurs when the product is used in maximum quantities, for a long period, or when the active ingredient is intolerant.

The nervous system to use the drug reacts with headache, drowsiness or insomnia, dizziness. These symptoms are observed quite often. On the part of the cardiac and vascular system, negative reactions occur in rare cases, manifested by a sharp drop in pressure, orthostatic hypotension. In addition, patients after taking the medication experience dry mouth, nausea, they may have dermatological reactions in the form of angioedema, itching or skin rash. In the presence of side effects, medication should not be withdrawn, negative symptoms after three weeks of use, usually disappear. However, it is still necessary to apply to a specialist.

Contraindications

Not in all cases you can take the medicine "Physiotenses". The doctors say that it is not recommended to take the medicine when:

• Pronounced bradycardia (pulse rate less than 50 beats per minute);
• SSSU;
• Hereditary intolerance or malabsorption of galactose (glucose)
• Deficiency of lactase;
• Increased sensitivity to constituent agents;
• Children and adolescents until they reach adulthood.

With caution appoint a drug in the terminal stage or severe degree of kidney failure, patients who are on hemodialysis, with severe liver failure.

Pills "Physiotenses": indications for use, testimonials, special instructions

The main diagnosis, in which doctors prescribe a medicine, is hypertension. It should be borne in mind that during therapy it is necessary to carry out systematic monitoring of the states of blood pressure, ECG and heart rate. If you need to cancel the medication, then you should do it gradually.

The agent does not adversely affect the ability to control machinery and transport. However, the drug "Physiotenses" (patient reviews indicate this) should be taken with caution, as it can cause dizziness and drowsiness. This fact should be taken into account by people engaged in dangerous activities that require constant concentration of attention.

Storage conditions, analogues and price

Tablets should be kept in a place where children can not reach. If the storage rules are observed (temperature to 25 degrees C, dark dry place), the medicine will not lose its pharmacological properties within two years. To buy a medication "Physiotenses" (the reviews confirm this) can be done by prescription in pharmacies. The price of packing tablets (0.2 mg) is 275 rubles. If the medicine in the pharmacy for some reason was not, then you need to look at the analogs: "Tsint", "Moxoniteks", "Moxonidine", "Moxogamma."

Reviews about the drug "Physiotenses"

Many patients respond to this drug as a quality effective remedy. People say that they have taken it for many years, the drug well lowers the pressure, while there is no side effect. Some refer to the shortcomings of the high cost of the "Physiotens" tablets. The reviews indicate a good compatibility of the drug with other hypertensive medications.