Prodrug "Parnavele": instructions for use

The drug "Parnavell" instructions for use characterizes as a prodrug, which is an ACE inhibitor and has a pronounced antihypertensive effect. The action of this agent is based on a competitive inhibition of ACE activity, which subsequently leads to a decrease in the concentration of angiotensin II. Thanks to the use of the drug Parnavell (instruction for use confirms this), preload, postload (OPSS) and resistance in pulmonary blood vessels decrease, and tolerance to exercise is increased. As for the pharmacokinetic properties of this drug, the pronounced hypotensive effect begins to be noted within the first sixty minutes after its administration, reaching its maximum after four to eight hours and remaining for a day.

The drug "Parnavel" is produced, the price for which varies from two hundred and fifty to three hundred rubles, in the form of ordinary round pills. In the composition of one tablet, the main operative element is perindopril erbumine in a volume of four milligrams.

Take the drug "Parnavell" instruction for use recommends exclusively for the treatment of chronic heart failure or hypertension. In this case, the initial dosage of the drug, as a rule, is one to two milligrams per day at one time, and the supporting dosage is two to four milligrams per day.

Experts strongly categorically recommend using Parnavell tablets to people with an individual intolerance to perindopril erbumin, as well as to all those who are predisposed to developing angioedema. In addition, the list of direct contraindications to the appointment includes pregnancy and age to eighteen years. In the lactation period, similarly should refrain from taking the drug "Parnavel". Instructions for use notes and undesirability of its use in the case of severe arterial hypertension or established renal failure. People suffering from a deficiency of fluid and sodium, before the start of the course of therapy should necessarily perform a correction of the so-called water-electrolyte disorders.

In addition, it is necessary with great care to use Parnavell tablets concomitantly with medications that can provoke a significant increase in potassium levels.

In conclusion, it should be said about the possible adverse reactions that can cause the drug. For example, experts note a rather high risk of dry cough, headache, dizziness, taste and dry mouth. In addition, there may be frequent mood changes, sexual dysfunction, skin rash, angioedema, convulsions, erythema, skin hyperemia, pruritus and urticaria. In addition, it is possible to lower the hemoglobin and increase the level of uric acid and creatinine due to the drug "Parnavel".