Prestarium: reviews about the drug

Preterium is a drug used in the therapy of cardiovascular diseases and is used to lower blood pressure. The "Preterium" medications available about the drug confirm its effectiveness in the treatment of hypertension and cardiovascular insufficiency. Its active substance is perindopril, which has a rapid vasodilating effect due to a decrease in the release of angiotensin II, which narrows the blood vessels. With systemic use of the drug, the elasticity of large arterial vessels and the reduction of left ventricular hypertrophy are restored.

In patients with chronic heart failure, the preparation of subendocardial collagen reduces the preparation Prestarium repeatedly. The reviews also testify to its normalizing effect on metabolic processes in cardiac myocytes. This drug helps to reduce preload and heart afterload, stabilizing its normal functioning. Under the action of the "Prestarium", the pressure decreases when filling the ventricles, which reduces the total atrial load. This drug is an inhibitor that reduces the pulse and increases the adaptability of the heart to increase physical activity.

With long-term use of the drug "Preterium" (the reviews confirm this) does not affect the potassium content in the blood and the efficiency of the kidneys. The hypotensive effect of the drug reaches its maximum effect after five hours and lasts for a day. After a month of systematic therapy, stable stabilization of blood pressure occurs, which persists for a long period of time. The withdrawal syndrome at the end of the reception of the "Prestarium" is not observed.

Patients suffering from cerebrovascular diseases who used Prestarium continuously for a long time, the reviews leave only thankful, indicating that active treatment with this drug reduces the risk of stroke and any serious cardiovascular disease many times. Perindopril does not affect the rate of glomerular filtration of the kidneys, increasing the movement of blood in them. This active drug component is rapidly absorbed into the blood after it is ingested. Its maximum concentration in plasma is observed one hour after taking the drug. Perindopril is converted to active perindoprilat by 20%, and the total bioavailability of the drug is 70%.

The medication "Prestarium combi" is produced in tablets of elongated form, covered with a film shell, which has a white color. One such tablet contains 5 mg perindopril arginine corresponding to 3.395 mg perindopril and 1.25 mg indapamide. As auxiliary substances in these tablets are added: glycerol, sodium starch glycolate, silicon dioxide, magnesium stearate, lactose monohydrate, titanium dioxide, macrogol and hypromellose. Before starting this medication, the doctor's permission is required to use it.

There are multiple contraindications to taking Prestarium (5 mg): pregnancy, period of feeding, hepatic encephalopathy, hypersensitivity to the components of the drug, hypokalemia, renal failure, angioedema. Taking this drug, you should carefully consider its compatibility with other medicines.