"Midokalm-Richter": description, instruction, application, feedback

"Midokalm-Richter" - an effective modern muscle relaxant, designed to relieve pain of different etiology and localization. The drug is available in a tableted and injectable form for parenteral use called "Midokalm-Richter" (injections). The reviews of many patients suggest that the drug is very effective in reducing muscle hypertonicity. The drug has an effect on the central nervous system, so taking it without prescribing a doctor is not recommended. Today, many readers are interested in the question of what is the "Midokalm-Richter" (injections)? Instructions for its use, indications and contraindications for use are described below.

Biochemical composition of the medicine

The composition of the medicament includes a complex of biologically active and auxiliary substances:

• Tolperisone hydrochloride (bioactive compound);
• Lidocaine hydrochloride ;
• Diethylene glycol monoethyl ether;
• Injection water;
• Methylparaben.

Pharmacodynamics

The exact mechanism of action of the drug "Midokalm-Richter" (injections) on the human body has not yet been deciphered. Scientists suggest that due to the effect of the drug on the afferent fibers, poly- and monosynaptic reflexes of the spinal cord are blocked. The bioactive components of "Midokalm-Richter" inhibit the release of the transmitter by blocking the entry of Ca ^{2+ ions} into synapses. Tolperisone hydrochloride exhibits weak spasmolytic and adrenoblocking action. And this is not all for the drug "Midokalm-Richter" indications for use. It activates the peripheral circulation, improves the metabolism of substances in the pathological zone.

Pharmacokinetics

After oral administration, the drug is well adsorbed by the mucosa of the small intestine. The maximum concentration in the patient's blood is observed in half an hour, the bioavailability with oral medication is about 20%. Tolperisone hydrochloride is metabolized in the tissues of the liver and kidneys. Isolation of metabolites occurs mainly through the kidneys.

"Midokalm-Richter": instructions for use

Given the pharmacodynamics of a drug, it is prescribed for very many pathologies associated with hypertension of muscle fibers. Most specialists recommend starting treatment with injections, and then switching to a tablet form of the drug. This treatment scheme ensures a quick recovery of the patient. The medication is prescribed for the following pathologies:

• Encephalopathy;
• ischemic stroke;
• Thrombophlebitis of the lower extremities;
• Diabetic angiopathy;
• Myasthenia gravis of central genesis;
• encephalitis;
• Obliterating endarteritis;
• Psoroid arthritis;
• Deforming osteoarthritis;
• Pain syndrome, provoked by osteochondrosis or radiculitis;
• Dystonia of muscles;
• lumbago;
• Menstrual pain;
• Little's disease in children;
• Intervertebral hernia;
• Rheumatoid polyarthritis;
• renal colic;
• hemorrhoids;
• Vascular sclerosis;
• Spondylitis;
• cholelithiasis;
• The threat of miscarriage due to hypertonicity of the myometrium;
• Autoimmune pathologies (Raynaud's syndrome, systemic scleroderma , etc.);
• Vascular sclerosis;
• Acrocyanosis.

Contraindications

If you decide to use "Midokalm-Richter" (injections), the instructions for use indicate that this medicine should not be used in the following cases:

• The period of bearing and breastfeeding of the child;
• Myasthenia gravis in severe form;
• Age category up to 18 years;
• Hypersensitivity to the ingredients of the drug.

The main analogs

The modern pharmaceutical market is famous for its wide range of medicines. Almost for each drug, you can choose an analog, similar in mechanism of action. Not an exception, and "Midokalm" - megapopular medicine, which has many analogues:

• "Sirdalud";
• Tolperizon;
• Tolperil;
• Mefidol;
• "Liorasel";
• "Miolgin";
• Baclofen.

Before replacing "Midokalm-Richter" (the instruction warns about this), it is necessary to consult with the attending physician, since only a qualified surgeon can make a qualified selection of this medication.

«Surdoolud»

One of the most popular analogues of "Midokalma". This powerful remedy, which can be taken once a day, it effectively reduces even the most severe pain. When taking the drug should be aware that it can cause excessive fatigue and drowsiness.

Tolperizon

The presented drug refers to muscular relaxants of central action. It is often prescribed for the treatment of muscle hypertension, obliterating vascular diseases. This tool is approximately twice as cheap as the original.

"Miolgin"

Analgesic and antipyretic effect of the drug is due to the presence in its composition of paracetamol. "Milgin" is prescribed for neuralgia, sprains and muscle strains. This is a fairly effective drug for headaches. Most experts do not recommend taking this medicine to patients under the age of 18, breastfeeding mothers and pregnant women.

Baclofen

This remedy is prescribed in extreme cases, because it has a number of side effects. It is important to remember that when choosing a particular analogue of the drug, read-only instructions for use are not enough. Choose a medication should be very carefully, strictly following the instructions of the attending physician.

Adverse events

Is there a side effect of such a drug as "Midokalm-Richter"? Instructions for use do not exclude the development of side effects. It:

• allergy;
• nausea;
• anorexia;
• Increased fatigue;
• Itching;
• Vomiting;
• Flatulence, diarrhea;
• Loss of balance, tinnitus;
• Strong thirst;
• Arterial hypotension;
• The appearance of a feeling of intoxication;
• Angioedema;
• Severe pain in the limbs;
• Dyspeptic and dyspeptic disorders;
• Muscle weakness;
• headache;
• nose bleed;
• Erythematous eruptions;
• tachycardia;
• Hyperemia of the skin;
• Shortness of breath, difficulty breathing;
• Rarely anaphylactic shock;
• Osteopenia;
• Excessive drowsiness;
• Decreased physical activity;
• Depression;
• Increase in the level of creatinine in the blood;
• Violation of liver transaminase activity (AST, ALT);
• A disorder of vision.

Overdose of the drug

Data on the overdose of the drug "Midokalm-Richter" is not so much. The medication is characterized by a wide therapeutic index. Preclinical studies have shown that when the drug is administered at doses significantly exceeding the recommended therapeutic levels, the following symptoms are observed:

• ataxia;
• Shortness of breath (until it stops);
• Tonic convulsive attacks.

It should be noted that there are no specific antidotes that neutralize the action of tolperisone hydrochloride. When an overdose is shown, immediate medical care (gastric lavage). The following is symptomatic and supportive therapy.

Interaction with other drugs

Studies on the compatibility of "Midokalma" with other medications are not available, therefore, before administration, the solution should not be mixed in one syringe with other medicines.

The use of "Midokalm-Richter" is allowed with sedative, hypnotic, and ethanol-containing drugs. If necessary, can be used in conjunction with other muscle relaxants, but in this case the daily dose of bioactive substance will need to be reduced.

"Midokalm" enhances the action of niflumic acid, as well as other NSAIDs, because of what the dose of the latter with a combined admission with this medication will need to be reduced. Pharmacological action of "Midokalma" is strengthened by the following medications:

• Clonidine;
• Muscular relaxants of peripheral action;
• Drugs used for general anesthesia;
• Psychotropic medicines.

"Midokalm-Richter" (injections) reviews

Many people are interested in the question of what exactly is "Midokalm". Instructions for use, the cost of medication, indications and contraindications are, of course, the main criteria for evaluating the drug. Nevertheless, it is worth familiarizing with the opinion of doctors and patients on this matter. Among doctors there is an opinion that "Midokalm-Richter" is one of the best modern muscle relaxants. The patient's feedback in this case coincides with the opinion of specialists, since the medicine is characterized by high efficacy, good tolerability and reliable relief of pain of different localization and etiology. In most cases (from 85 to 95%) reviews about the drug are positive. You can find rare negative reviews, which indicate that treatment with this medication is not effective enough. The drug "Midokalm-Richter", the testimony to the application of which was considered in this article, is released strictly according to the prescription. In case of any complications, the patient should consult a doctor.