Pantothenic acid: instructions for use, composition and analogues of the preparation

Anti-stress vitamin, beneficial to the entire human body, called the physicians this substance. In its pure form, pantothenic acid, the instructions for use, reviewed in this article, was isolated by biochemist Roger Williams from the liver of mammals in 1933. Only after ten years the scientists found out its chemical formula and carried out the synthesis of calcium pantothenate - salt on its basis. Water-soluble vitamin B5 - a vital nutritional supplement for any organism, activating the cleavage of all macronutrients (fats, proteins and carbohydrates). It helps to improve metabolism and increase energy levels in the body.

What is an anti-stress vitamin?

Free pantothenic acid (in ampoules), the instruction for its use characterizes it as a water-soluble viscous substance of light yellow color with an oily consistency, is also easily diluted in acetic acid, but it is bad in alcohol and does not dissolve at all in fatty substances. Calcium and sodium salts of pantothenic acid crystallize well and are a white powder or vitamin B5 tablets. In powder, this substance has no smell and is bitter to taste. Under the influence of acids, alkalis and heat, the popular water-soluble vitamin is easily destroyed.

Synthesis of pantothenic acid in nature

In natural conditions, vitamin B5 is formed by green plants, as well as by individual microorganisms in the human intestine. The concentration of pantothenic acid in natural products is different, but its presence in virtually any of them is mandatory. No wonder in translation the Greek word "pantos", contained in the name of the acid, means "everywhere" or "omnipresent". Thermal treatment of food products containing pantothenic acid (instructions for use is presented below) is not recommended, because during the cooking, quenching, roasting or smoking, vitamin B5 loses its properties and collapses. In addition, when you add vinegar, citric, malic acid in the dish, the concentration of the anti-stress substance is also significantly reduced.

Pharmacological properties and dosage

Miracle pantothenic acid, the instruction for its use recommends its use for children from 2 to 5 grams per day, and for adolescents from 11 years and adults - 4 to 7 grams, is a constituent element of coenzyme A, which stimulates metabolic processes in the body.

Its action extends from the synthesis of adrenal hormones (glucocorticosteroids), which prevent the occurrence of many diseases (arthritis and allergy, colitis and heart diseases), to neurotransmitters, from the formation of antibodies that promote the assimilation of many other vitamins, to regulate the metabolism of fatty acids, which normalizes lipid metabolism and Has a favorable effect on oxidation-reduction processes in the human body.

Stimulating intestinal peristalsis, pantothenic acid, the instruction for its use recommends it in case of abnormalities in the gastrointestinal tract, improves the functioning of the digestive tract, has a powerful reparative (healing) effect on mucous membranes. Its lipid-lowering properties make it possible to reduce the concentration of harmful cholesterol in the vessels by splitting its individual fractions and removing them from the body.

Deficiency of pantothenic acid

The lack of the most important anti-stress vitamin leads to disturbances in metabolism, worsening of long-term memory, exacerbation of nervous and skin diseases, reduced immunity, the appearance of allergic reactions, and failure of the rhythm of sleep. With a deficiency of vitamin B5, sensitivity to odors and tastes is sharply reduced, absent-mindedness appears, in the presence of bad habits, the harmful influence of tobacco and alcohol on brain activity increases, the condition of the skin, nails and hair deteriorates. In addition, the healing of burns and wounds lasts longer. The possibility of the onset and development of atherosclerosis also increases significantly. The inadequacy of pantothenic acid in the body can provoke vomiting and dizziness, increased fatigue and general weakness, loss of coordination and muscle spasms, dermatitis or eczema, autoimmune diseases, arthritis and arthrosis, obesity.

Indications

Vitamin supplementation of calcium pantothenate, or pantothenic acid, in tablets (the instruction with detailed description of which is in each package) is prescribed for headaches and sleep disorders, for numbness of limbs and muscle ailments, during periods of emotional overstrain and heavy physical exertion, to relieve depressive and Apathy states, with alcohol abuse, with liver and other gastrointestinal dysfunction, with failures in metabolic processes, with weakening of immunity, with bronchitis, for the prevention of diseases of org. new digestion, in acne, as well as during pregnancy and breast-feeding a baby.

Contraindications and side effects

Contraindications, except for an individual allergic reaction to vitamin B5, there is no safe food supplement. However, pantothenic acid, whose side effects may occur in case of an overdose of the drug, requires strict adherence to medical recommendations.

Unpleasant symptoms are expressed in various dyspeptic phenomena (nausea, heartburn or vomiting). Gastric lavage and temporary restriction of vitamin intake are sufficient to relieve discomfort. When this drug is taken in combination with cardiac glycosides , the action of the latter increases, and the toxicity of antituberculous agents and arsenic is significantly reduced.

Analogs and composition

Proper nutrition satisfies the daily requirement of a person in vitamin B5, since most products of plant and animal origin contain natural pantothenic acid. Instructions for use (analogues of the anti-stress vitamin - "Calcium pantothenic" and "Calcipan", "Kutivitol" and "Kalpanat", "Pantolin" and "Pancal", "Pantotaxin", "Pantothen" and "Pentavitol") recommends it in the form of tablets Or capsules as a bioactive additive to food.

Pantothenic acid is manufactured by Solgar (USA) in the form of capsules with active substance (500 mg) or a multivitamin complex based on natural components called "Solgar Multi Ai."

Domestic producers of "Pantothenate calcium" produce: "Belgorodvitaminy", "Pharmstandard-October", "ICN Russia October" and "Akrihin HFC" in tablets of 0.1 g, packed in 50 pieces.

Foreign analogues of the drug called "Calcium D-pantothenate" are manufactured by DSM NUTRITIONAL PRODUCTS Ltd. (Switzerland) and NOW Foods (USA). In addition to tablets and powder (capsules), this substance is sold in the form of ampoules with a 10- or 20% solution for injection. Among the analogues of this drug are "Aminalon" and "Neuro-Norm", "Vasavital" and "Noobut", "Noofen" and "Noozam", "Calcium Pangamate" and "Supradin", "Vitrum Beauty" and other multivitamin complexes with component B5 in the composition.

Reviews

The opinions of most people who take vitamin B5 as indicated are positive. Someone praises the drug for a soothing effect, because irritability disappears and sleep improves. Athletes liked its restorative effect for muscles after exhausting workouts and injuries, as well as a surge of energy and help in concentration during the competition. In other patients suffering from acne, pantothenic acid in high doses contributed to a rapid cure for the disease. Patients visiting the dermatologist, report a good therapeutic effect of vitamin B5. Pregnant women, suffering from toxicosis, note the improvement in the state after a week of regular intake of calcium pantothenate tablets.

But not only the intake of this drug inside has a beneficial effect on the health of the skin, the appearance of the hair and nails. Cosmetologists found a similar effect in the external application of all kinds of creams, shampoos, gels, sprays and ointments (Bepanten, Panthenol and others). Positive feedback about these drugs stimulates many people to purchase and store them in every home medicine cabinet. The only minus of intramuscular injections based on pantothenic acid, as noted by patients, is soreness in the areas of injections and the possible emergence of infiltrates. The intake of capsules or tablets "Pantothenate calcium" can be a good alternative to an effective but painful invasive procedure.