Which antituberculous drug is best used for treatment?

In time revealed tuberculosis of the lungs is cured for a period of time from 10 calendar months to 1.5 years. How long the treatment will last depends on the severity of the disease process and on the appointment of the most suitable individually selected medication.

Tuberculosis in our time is a curable disease

In the modern antibiotic therapy of tuberculosis in the prerogative is a combined treatment. This is because with the simultaneous receipt of different drugs, the resistance of microbacteria to the drug develops much slower. The patient is prescribed for course taking 2 or 3 drugs at once. Fortunately, the possibilities of medicine today are vast. It can only be anti-tuberculosis drugs of the 1st row or a combination of them from compositions I and II of the series.

Classification of antituberculous drugs is built according to the degree of their effectiveness. By the way, many thanks to our research institute for the invention of such a drug as isoniazid. This is one of the main anti-tuberculosis drugs, its advantage in very high bacteriostatic activity. In this case, especially effective its reception in the newly ill patients.

Next on the list

The second most effective treatment after "Isoniazid" is "Rifampicin". Also a wonderful and effective remedy. The activity of the following preparations can be distributed in such a sequence: Streptomycin, Kanamycin, further Pyrazinamide, Ethionamide, followed by Prothionamide, Etambutol, and 3: Florimycin, Pas, Preparation "Thioacetazone".

All drugs that affect mycobacteria and help solve clinical problems of patients were divided into groups of anti-tuberculosis drugs:

1. Antibacterial essential anti-tuberculosis drugs of the 1st series,
2. Reserve drugs II series.

What is the difference between drugs 1 and 2 of the series

In the first row are the main medicines that claim the highest efficacy of chemotherapeutic agents and their derivatives. Have minimal toxicity.

Anti-tuberculosis drugs of the 2 series, including reserve medicines, do not have such a high result in the fight against Koch's stick, while they are quite toxic. They are prescribed to patients in the event that their body is immune to the drugs of the 1st row or there is an intolerance of these medicines.

Sad statistics show that any drugs in time cause addiction to the body, that is, the effectiveness is significantly reduced. Also, the main antituberculosis drugs cause addiction after a certain period of time and therefore the mycobacteria become immune to them. For example, if only one particular drug is taken alone, resistance to it with mycobacteria is observed after 2-4 months.

Anti-TB drugs: use and impact

Most of the medicines of the anti-tuberculosis attack bacteriostatically affects the mycobacteria, that is, they reduce their virulence and inhibit the ability to reproduce. Similarly, "Isoniazid" and "Rifampicin" in concentrated doses have the ability to act bactericidal. In order to obtain a stable therapeutic effect, as well as to prevent and avoid possible relapses, the use of antituberculosis drugs should last for a long time.

At the same time, the choice and purpose of the best combination of drugs, as well as the period of their use, directly depend on the patient's current form of tuberculosis, on the means by which the previous treatment was performed (if any), on the patient's tolerance of certain medications , How much mycobacterium tuberculosis is sensitive to the selected drugs.

Better compatibility

Combination of anti-TB drugs is planned, based on the fact that one or two first-line drugs must be present in the treatment program. Of course, if they do not have any contraindications or manifestations of resistance to them. In this case, the dose of all drugs taken, as a rule, does not decrease.

When appointing (reminder phthisiologist), it must be borne in mind that an anti-tuberculosis drug such as streptomycin and its derivatives can not be combined with florimycin, kanamycin and other antibiotics that have nephro- and ototoxic effects.

What kind of drug "PASK"

"PASK" is an antituberculous preparation of bacteriostatic effect. Yes, the days of the scientists of the pharmacologists who created it will last. Very active against tuberculous mycobacteria. Effective in the treatment of various forms and different localizations of tuberculosis. It gives an even better effect when other anti-tuberculosis drugs are combined with it.

The drug has the Latin name "PASK-AKRI". Produced either in bags of 4 g or in a 100 g bank. In one packet of the drug "PASK" contains 3.2 sodium aminosalicylate, and in one tablet - 1 g of sodium para-aminosalicylate. The tablets are covered with a gastric membrane and on sale are packaged 50/100/500/1000 pcs. packaged.

With which it is better to combine

Anti-tuberculosis drug "PASK" is inferior to drugs such as isoniazid and streptomycin in terms of indicators of tuberculostatic activity, therefore it should be prescribed simultaneously with more active agents. Combination therapy slows the development of drug resistance and enhances the effect of concomitant medications.

Pharmacokinetics "PASK"

The drug has a high (90%) absorption. Metabolised in the liver. It is able to easily penetrate through the histohematological barriers and be distributed in tissues. The highest concentration of the drug is observed in the lungs, kidneys and liver. More moderately "PASK" (anti-tuberculosis drug) penetrates into the cerebrospinal fluid. But in case of inflammation of the membranes in the cerebrospinal fluid, the concentration of aminosalicylic acid is 10-50% of its concentration in the blood plasma. Most (80%) of the drug is excreted mainly with urine.

Preparations of the II series

Anti-tuberculosis drugs of the 2nd series with their correctly selected and timely appointment have an excellent therapeutic effect, expressed in the detoxification of the body, plus a significant regression of inflammatory changes in the lung tissue, and even in the cure of bronchial tuberculosis.

According to medical studies in the treatment of children and adults with complicated, chronic and destructive forms of tuberculosis, various combinations of preparations of series II, given the clinical resistance and resistance of strains of bacteria to the first-line drugs in patients, 65% of the cases were obtained, which is very encouraging , An additional clinical effect.

Anti-TB drugs: side effects

And, of course, they are interested in those who take the drugs described in the article, their possible side effects. Moreover, from the drugs introduced in recent years in the practice of medicines, antituberculous drugs deserve special consideration. This is due to the fact that this disease will soon cross the epidemiological threshold, despite the significant decline in the incidence rate since the Second World War. Important is the fact that the treatment of tuberculosis, as already mentioned above, the process is quite long, and the negative effect of drugs is manifested either in overdose or long-term administration.

Some statistics

With anti-tuberculosis therapy according to the reports of foreign and domestic representatives of medicine, the side effects of the respective drugs and their incidence are as different as the nature of the course of the disease. For example, out of 3148 patients treated with funds active against mycobacteria, adverse reactions were observed in only 12.2% of people, most of them having allergic reactions, and only 74 patients developed toxic poisoning.

Based on the published materials, it can be concluded that the observed side effects of antituberculosis drugs differ in the frequency of reactions. Their large fluctuations are due to the heterogeneous treatment conditions, when not only the medicines used are important, but also the form of tuberculosis, as well as the age of the patients, even the types of medical institutions (hospital, sanatorium, clinic, institute).

Research continues

Medicines that are destructive to Koch's sticks include a number of natural and semi-synthetic compounds that share one common property: their activity in relation to, that is, the tuberculosis mycobacterium (M. tuberculosis). Anti-tuberculosis drugs, the classification of which, as mentioned at the beginning of the article, divides medicines into 2 series (basic and reserve) are of great interest for scientists.

Particular attention is paid to the development of tuberculosis mycobacteria resistance. All the studies are carried out laboratory, and on this issue the results showed that in the majority of patients the degree of drug resistance in the course of treatment can vary both upward and downward, sometimes reaching almost complete recovery of sensitivity.

Reduction of adverse reactions

When side effects occur during the treatment, first of all it is necessary to reduce doses of drugs or to replace some drugs with others. In a severe case of adverse reactions, the antituberculous drug is temporarily prohibited from being taken, followed by a replacement for another. To prevent and eliminate the symptoms of coronary insufficiency, the patient is appointed depending on the indications of any of the preparations of a number of antispasmodics, for example: "Euphyllinum", "Papaverin", "Theoephedrine", drops "Zelenin" , etc.

Characteristics and severity of adverse events with antituberculous therapy are quite diverse. Anti-tuberculosis drugs, the classification of specific manifestations in which the same in terms of chemical characteristics, are grouped together to simplify research.

Anti-tuberculosis therapy

In the treatment of tuberculosis diseases, prevention of the spread of infection is also an important task nowadays. The threat comes from patients suffering from pulmonary tuberculosis in an open form. Their intensive treatment will help in reducing the number of infected, as well as in preventing new cases of this unpleasant disease.

Since the treatment is long, the patient needs a lot of patience and self-discipline. After all, tuberculosis causes damage not only to the affected organ, but to the whole organism as a whole. It is very important to start antimicrobial therapy on time, in which the most powerful artillery is used, that is, the main antituberculous drugs. Thanks to them, it is possible to stop bacilli excretion at an early stage, which will help restore the affected organ with virtually no damage to the entire body.

The complex treatment, which will be administered taking into account the age and the identified form of the disease, includes the impact on pathological processes in the diseased organ, a reduction in the level of concomitant symptoms (pain, cough) with the use of inhalations and various methods of physiotherapy.

Admission of a prescribed group of medicines must be regular, as an unsystematic approach can lead to the development of resistance to them. Treatment should be carried out in a hospital under the supervision of a doctor. After discharge, a phthisiatrician must be observed.

A serious approach and the implementation of all medical prescriptions and appointments is the key to a full recovery. In our time, tuberculosis is not a verdict.