Metamizol sodium

"Metamizol sodium" has its own anti-inflammatory, antipyretic and analgesic effect due to the fact that the synthesis of prostaglandins from arachidonic acid is blocked, pain impulses are broken, heat transfer increases and the threshold of pain sensitivity increases.

This drug is fairly well absorbed in the digestive tract, where it hydrolyses and the formed active metabolite almost half binds to blood proteins. This drug is excreted together with urine, and it also penetrates into breast milk.

"Metamizol sodium" - instruction for use

The drug is prescribed to reduce the pain syndrome of any origin, whether it be neuralgia, headache, myositis or sciatica. It is also taken with influenza, febrile conditions of rheumatism and other diseases.

It is recommended to take "Metamizol sodium" from 250 to 500 mg inside do it 2-3 times a day. The daily dose should not exceed 3 g, and the single dose should not be more than 1 gram.

Children aged 2-3 years are recommended to take up to 50-100 mg of the drug, at the age of five years -100-200 mg, up to seven years -200 mg and up to 14 years -250-300 mg of this drug, it is taken in accordance with these recommendations.

Also, "Metamizol sodium" can be taken and intravenously and intramuscularly, while it is administered up to three times throughout the day, but not more than 2 grams per day, and for children it is recommended to take 0.1-0.2 ml for every 10 kg of body weight Body.

Contraindications for use

It is not recommended to take this medication in the presence of bronchospasm, high sensitivity to metamizol sodium, hematopoietic disorders, hereditary hemolytic anemia, renal or hepatic insufficiency, during lactation and pregnancy.

Possible side effects

The use of the drug "Metamizol sodium" can cause such phenomena as interstitial nephritis, oliguria, urine becomes red, proteinuria, anuria. There may also be allergic reactions in the form of conjunctivitis, urticaria, Quincke's edema, sometimes anaphylactic shock, bronchospastic syndrome, Lyell's syndrome may develop . Leukopenia, lowering blood pressure, agranulocytosis, thrombocytopenia, infiltrates at the site of administration can also be as side effects of this drug.

With caution take "Metamizol sodium" is necessary for multiple trauma, with the presence of arterial hypotension, myocardial infarction, chronic alcoholism and starting shock.

If there is a need for long-term use of this drug, then you need to carefully monitor the composition and condition of peripheral blood.

With simultaneous administration together with chlorpromazine, hyperthermia can develop. "Metamizol sodium" is not combined with benzylpenicillin with colloidal blood substitutes and with radiopaque substances.

The administration of this drug, together with hormonal contraceptives, non-narcotic analgesics, allopurinol and tricyclic antidepressants, can cause an increase in toxic effects.

Also produced "Metamizol sodium-Pitophenone-Fentiverinia bromide", which is a combined agent that has antispasmodic and analgesic effect.

When an overdose of the drug occurs nausea, oliguria, convulsions, gastralgia, a decrease in blood pressure, hypothermia, dyspnea, tachycardia, tinnitus, delirium, drowsiness, acute agranulocytosis, paralysis of the respiratory muscles, impaired consciousness, hemorrhagic syndrome.

In such cases, the gastric lavage is performed with the help of a probe, saline laxatives and necessarily activated charcoal are taken. Also, hemodialysis, forced diuresis, and with convulsions - iv diazepam and fast acting barbiturates can be performed.