Lidocaine remedy. Instructions for use and description

The medicine "Lidocaine" is an analgesic, which in its structure belongs to the derivatives of acetanilide. The drug has a local anesthetic and antiarrhythmic effect of an expressed nature. The drug helps to inhibit nerve conduction by blocking sodium channels in nerve fibers and terminations. The local anesthetic effect of the drug "Lidocaine" (experts' reviews confirm this) significantly exceeds the intensity of the action of the Procan. The activity of the former develops more quickly and persists for a longer period. When combined with Epinifrin, the duration of action is increased to two hours. Antiarrhythmic effect is due to its ability to normalize the cell membrane, inhibit sodium channels, increase membrane permeability for potassium ions. The medication "Lidocaine" (the instruction for use indicates this) practically does not affect the electrophysiological state of the atria. At the same time, repolarization in the ventricles is accelerated. Within five to fifteen minutes after intravenous administration, the maximum concentration of the drug in the blood is noted. Without the initial saturating dose with slow infusion (IV) - after five to six hours. Approximately 50-80% of the drug binds to plasma proteins. The distribution of the drug on tissues and organs is quite fast.

Contraindications

The medicine "Lidocaine" (the instruction for use warns about this) is not recommended for pregnancy, intolerance, the presence in the anamnesis of data on the presence of epileptiform seizures on the ground of drug administration. Contraindications include cardiogenic shock, atrioventricular blockade, weakness of the sinus node, myasthenia gravis, severe liver pathology.

Lidocaine remedy. Instructions for use. Side effect

The drug can provoke the excitation or oppression of the central nervous system, euphoria, nervousness, drowsiness, photophobia, flies before the eyes. Patients may experience headache, diplopia, disorientation, dizziness, convulsions, stopping or suppressing breathing. To negative consequences should be attributed tremor, muscle twitching, frustration, tinnitus. The drug provokes transverse cardiac blockade , bradycardia, collapse, change (decrease or increase) of pressure. When using the medication, probably numbness of the limbs, a feeling of heat, anaphylactic shock, exfoliative generalized dermatitis. The negative consequences include vomiting, angioedema, nausea, dyspepsia, discomfort in the abdomen. In patients, immunosuppression may also be noted.

Dosing regimen

The drug "Lidocaine" instruction for use allows you to inject subcutaneously, intramuscularly, intravenously (depending on the type of anesthesia). The maximum dosage is four hundred milligrams.