"Nimid" (tablets): instructions for use and reviews

People suffering from diseases of bones, joints and muscles as symptomatic therapy often appoint doctors "Nimid" (tablets). Instruction for use contains information that this drug not only relieves pain, but also has an anti-inflammatory effect. Let's try to study the characteristics of the drug in more detail and find out in which cases it is able to help.

Forms of medicines and their composition

As for the forms of the drug, at present pharmacies can buy tablets, suspension, granules and gel. The main active substance in them is nimesulide. The tablet form of the drug is produced in blisters of 10 pcs. One tablet contains 100 mg of nimesulide, and microcrystalline cellulose, sodium stearate, croscarmellose sodium, and aerosil 200 are used as auxiliary components for pharmacists. This information contains the instruction for use on the composition of the Nimide preparation (tablets).

Powder is produced in metered bags. This form of the drug is convenient for treating children. After all, in the composition, in addition to nimesulide, Povidone K-30, Tabletose 80 and Aerosil 200, contain auxiliary substances such as sodium saccharin, citric acid and flavoring additives. A crumb with pleasure will drink the delicious therapeutic "cocktail" prepared by parents.

1 ml of the suspension and 1 g of the gel contain 100 mg of nimesulide. As auxiliary components in these two forms, propylene glycol, sodium hydroside, carbomer 940, disodium edelate, aromatizer, purified water and methyl paraben are used.

Pharmacological action of the drug

Nimesulide, which is the active substance of this medication, belongs to the group of non-steroidal anti-inflammatory sulfonanilides. Getting into the human body, it selectively inhibits COX-2 and suppresses the synthesis of prostaglandins in the focus of the inflammatory process. Analgesic, antipyretic and anti-inflammatory effect is achieved only after taking one "Nimid" -tablets. The instructions for use contain more information on the dosage of the drug.

In addition to all of the above, the drug is able to inhibit the release of free oxygen radicals and suppress the release of myeloperoxidase, without affecting the processes of phagocytosis and chemotaxis.

As for the anti-inflammatory action of the drug, it is achieved due to the ability of nimesulide to inhibit the mediators of the inflammatory process and to reduce the factors of tumor necrosis. Inhibiting the synthesis of interleukin-6 and urokinase, the "Nimid" preparation (the instruction for use confirms this fact) prevents the destruction of proteoglycans and cartilaginous collagen. In addition, nimesulide blocks the painful impulses from the nociceptive system.

If we consider the mechanism of analgesic action, it is associated with the inhibition of the release of histamine from numerous mast cells and the effect of the active substance on glucocorticosteroid receptors.

If the doctor has prescribed "Nimid" (tablets), the instructions for use should be carefully examined before taking the medication. After all, this document contains recommendations that must be taken into account during the course of therapy.

Pharmacokinetics

After taking the recommended dose, the drug is actively absorbed from the digestive tract. And after 1.5-2.5 hours, the maximum concentration of the active substance in the blood plasma is noted. A characteristic feature of the drug is a high ability to interact with proteins, as well as penetration through the blood-brain and hematoplacental barriers. In high concentrations, nimesulide is detected in the focus of the inflammatory process and in the synovial fluid.

The metabolism of the drug occurs in the liver, then, mostly in the unchanged form of active metabolites, it is excreted through the kidneys (with urine), the smaller - with the calves. The half-life of the active substance is reached after 3.5-5 hours. Contains more specific pharmacokinetic data on the preparation "Nimid" instructions for use.

Indications

Effective drug for fever, which accompanies the diseases of ENT organs and upper respiratory tract. It is often prescribed to people suffering from rheumatoid arthritis, myalgia, osteoarthritis, bursitis, tendinitis, as well as other diseases of muscles, joints and bones accompanied by pain syndrome. In the dental and gynecological practice, with the post-operation and post-traumatic pains, the "Nimid" medication is also used. Instructions for use in such cases recommend purchasing tablets, powder or granules.

As for the drug in the form of a gel, it is intended for topical use in inflammations of the tissues (soft), which are caused by various injuries. It is also effective in inflammatory processes and degenerative ailments of the musculoskeletal system, osteoarthrosis, Bekhterev's disease , etc. Contains an expanded list of indications for the use of the Nimid® preparation for use from the manufacturer.

Reception conditions and dosing system

If it is a question of taking medication in the form of tablets, suspension, then it should be consumed only after a meal. It is desirable that after eating, not less than 20 minutes have passed, otherwise the pharmacokinetic effect of nimesulide is slowed down. As for the dosing of the drug and the duration of the course of treatment, these questions should be answered directly by the attending physician, taking into account the individual characteristics of the patient and the severity of the ailment. Therefore, we will only consider general recommendations that contain the instructions for use about the Nimide medication.

Tablets adults are prescribed usually twice a day for 100 mg. In severe forms of the disease, the daily dose can be doubled. Adolescents from 12 to 18 years are recommended to calculate the dosage of the drug at a rate of 1.5 mg per 1 kg of body weight. If treatment is required for a child under the age of twelve and weighs more than 40 kg, he is prescribed 100 mg of medication per day, dividing the norm into two doses. In exceptional cases, the doctor may increase the recommended dose.

The agent in the form of granules is prescribed to children from 12 years of age and adults to 1 sachet in the morning and evening. The contents of the sachet are diluted in 100 ml of warm water and drunk after eating.

With regard to the gel "Nimid", then - no more than 4 times a day - apply a thin layer (not rubbing) on the area of the body with the most severe pain syndrome. After using the medication, wash hands thoroughly with soap and water under running water.

Who is contraindicated with the drug?

Do not prescribe medication for people with peptic ulcer, marked violations in the liver and kidneys, as well as with hepatotoxic reactions to nimesulide in the anamnesis. Categorically contraindicated drug with a tendency to various bleeding, heart failure and hypersensitivity to one or several components of the medication "Nimid Forte." The instructions for use also contain information on the prohibition of the use of the drug in combination with potentially hepatotoxic drugs, with fever, influenza-like conditions and suspected surgical acute pathology.

As for the agent in the form of a gel, it is not prescribed for patients younger than 12 years and people prone to allergic reactions. To aggravate the course of the disease, the use of medication can occur with dermatitis, damage and infections of the skin, as well as in bronchial asthma, which is caused by ASA. That is why, with the above pathologies, no Nemid remedy is prescribed. Instructions for the use of tablets in such cases, too, does not recommend the use.

Can I take medicine during pregnancy?

Scientists have found that nisumelide is able to affect fertility. In addition, it inhibits the synthesis of prostaglandins, which, as we know, can be the cause of the development of malnutrition, pulmonary hypertension, oliguria and premature narrowing of the Batalov duct. The risk of weakening labor, the occurrence of peripheral edema and bleeding with the use of Nimid medication may increase. Instructions for the use of tablets and other forms of medicine categorically prohibit both during pregnancy and during lactation. After all, the active substance, together with breast milk, can enter the child's body and disrupt the functioning of its vital systems. In the same cases, when it is impossible to dispense with medicine, and the benefit to the mother exceeds the risk of harm to the baby, the dosage and course of therapy is determined by the doctor.

Side effects

In addition to the mass of positive pharmacological characteristics, the drug also has an impressive list of side effects. So, let's see what kind of reactions can occur when using the "Nimid". Tablets (the instruction in Russian provides these data) can cause itching, hives, various skin rashes, angioedema, and in some cases even Stevens-Johnson syndrome and epidermal necrolysis. GASTROINTESTINAL TRACT can, in turn, react to a medicine with constipation, diarrhea, sometimes in patients there were pains in the field of a stomach, a nausea. Very rarely, taking tablets can cause perforation of the ulcer and peptic ulcer of the stomach and duodenum.

Since the process of metabolism occurs in the liver, it also suffers from this. Therefore, long-term use of the drug in some cases may cause changes in the activity of transaminases, cholestasis, jaundice development and even acute hepatitis. The same violations in the liver cause not only tablets and granules, but also the powder "Nimid".

The instruction specifically describes possible reactions of the genitourinary system when taking the medication. It can be as edema, dysuria, urinary retention, and oliguria, acute renal failure, interstitial nephritis. On the part of the respiratory system, dyspnea and bronchospasm are possible, long-term use may cause asthma.

In addition to the above effects, the patient can develop tachycardia, arterial hypertension, hypothermia, asthenia and other diseases. Almost all adverse reactions are recommended to cancel the medication and immediately consult a doctor. In order not to be in such a situation, it is necessary to carefully study all possible information about the drug and only then take Nimid Forte (tablets). Instruction for use, which is in each medicine package, will help in this.

Overdose and first aid algorithm

If you accidentally exceeded the permissible dose of the drug, you must immediately go to the hospital. After all, the consequence of such a mistake can be drowsiness, nausea, vomiting, pain in espigastria, apathy, increased blood pressure. And this list of only the lightest reactions of the body to the increased dose of the drug "Nimid". Tablets, - the instruction warns about this - taken in an amount of 2-3 pieces above the allowable rate, can cause internal bleeding, as well as lead to kidney failure. In medical practice, even rare cases of anaphylactoid reactions, respiratory depression and coma caused by an overdose of this drug have been recorded.

If the permissible dose is exceeded, waiting for clinical manifestations is not worth it. It is necessary to immediately wash the stomach, take an osmotic laxative and enterosorbents. It is advisable to contact the hospital after the above described events, where the specialists will continue symptomatic treatment. It is worth noting that today there is no specific antidote.

What do patients think about the drug?

Of course, for diseases with acute pain syndrome, almost all patients respond well to the medication that we are considering. They note that the effect of using the drug comes fairly quickly, which can not but rejoice. Quite a few other comments can be heard when patients were prescribed a long course of therapy with Nimid. Tablets (the instruction recommends to pay special attention to this pharmacological property of the drug) quickly relieve pain, but after a few days of reception, side effects appear. The first to react to nimesulide is the gastrointestinal tract, later the nervous system (manifested by irritability, rapid change of mood and propensity to apathy).

Of course, it's not right to say categorically that a medicine does more harm than good. After all, it really helps. But to take it without evidence and appointment of a specialist is not recommended.

If, after the above information, there are doubts as to whether it is worth buying Nimid (tablets), the instructions, patient testimonials and the advice of the attending physician will help to make the right decision.