Hypothalamic rhythm releasing hormones

Releasing hormones are human neurohormones that synthesize the nuclei of the hypothalamus. They oppress (statins) or stimulate (liberins) the production of tropic hormones in the pituitary gland. The work of the endocrine glands is activated, and the regulation of their release of hormones occurs. The higher departments of the central nervous system and the endocrine system are in close connection because of the releasing hormones.

Functions of the hypothalamus

One of the important components of the endocrine system, responsible for the production of hormones, is the hypothalamus. The substances produced by the hypothalamus are hormones involved in the metabolic processes of the body.

In the hypothalamus there are nerve cells that ensure the production of the necessary substances necessary for the body to function properly. These cells are called neurosecretory. Their task is to receive pulses that transmit different parts of the nervous system. Isolation of elements occurs through axovasal synapses.

Hypothalamic-releasing hormones or, as they are called in another way, statins and liberins, are extremely necessary for the normal functioning of the pituitary gland. In their chemical nature, they are peptides. Thanks to chemical and nerve impulses, their synthesis occurs, they are transported to the pituitary gland by blood on the hypothalamic-pituitary system.

Classification of hormones

Consider the most famous releasing hormones:

• Inhibitory secretory function of the pituitary gland - it is a question of somatostatin, melanostatin, prolactostatin.
• Stimulating - we are talking about melanoliberin, prolactoliberin, folliberin, luliberine, somatoliberin, tiroliberin, gonadoliberin and corticoliberin.

The listed substances, more precisely some of them, can be produced by other organs, not only the hypothalamus (for example, the pancreas).

Statins and Liberians

The functioning of the pituitary gland directly depends on them. They also affect the functioning of peripheral endocrine glands:

• thyroid gland;
• Ovaries in girls;
• Testicles in the male sex.

Statins and liberins, which are best known:

• Dopamine;
• Gonadoliberin (luliberin, follinerin);
• Melonostatin;
• Somatostatin;
• Thyroidiborin.

The secretion of luteinizing and follicle-stimulating hormones of the pituitary gland is provided by gonadoliberins.

The activity of androgens in men is also affected by gonadoliberins, contributing to increased sperm activity and libido levels.

And in women, neurohormones are responsible for the menstrual cycle, and the amount of hormones varies depending on the phase of the cycle.

Insufficient development of releasing hormones often causes infertility and impotence.

Characteristics of hormones

The hormone corticoliberin, responsible for the sense of anxiety, is produced by the hypothalamus. This is another important releasing factor, acting in concert with the hormones of the pituitary gland and affecting the work of the adrenal glands. People with a deficiency of this hormone often suffer from hypertension and adrenal insufficiency.

Gonadoliberin - a hormone that increases the production of gonadotropins - is also a product of the hypothalamus. It is also called gonadotropin-releasing hormone.

The normal functioning of the genital organs can not do without gonadoliberin. It is this hormone responsible for the natural course of the menstrual cycle in women. With his participation is the process of maturation and release of the egg. This hormone is responsible for the libido (sexual desire). In case of insufficient production of this hormone by the hypothalamus, infertility often develops in women. What other rhizome hormones are there?

Somatoliberin

The most vividly stands out in childhood and adolescence. Its main property is the normalization of the growth processes of organs and body systems. From its development depends on the full development and formation of the child. Insufficient production of this hormone of the hypothalamus can lead to nazism (dwarfism).

Prolactoliberin

Its development is most active in the period of gestation and during the entire period of feeding the child by the mother. This releasing factor normalizes the production of prolactin, which forms the ducts of the mammary glands.

Prolactostatin

Prolactostatin belongs to the subclass of statins produced by the hypothalamus, it is responsible for oppression of prolactin.

Prolactostatins include:

· Dopamine;

· Somatostatin;

Melanostatin.

Their main action is aimed at suppressing the tropic hormones of the pituitary and hypothalamus.

Melanotropin-releasing hormone

The process of melanin production and separation of pigment cells is affected by melanoliberin. It also affects the elements of the pituitary gland pituitary.

Affects the neurophysiological behavior of a person. It is used to relieve depressive conditions and treat Parkinsonism.

Thyrotropin-releasing hormone (TRH)

To thyrotropin-releasing hormones of the hypothalamus also includes tiroliberin. It promotes the production of thyroid-stimulating hormones of the adenohypophysis.

It has an insignificant effect on the production of prolactin. Tyroliberin provides an increase in the concentration of thyroxine in the blood.

The CNS has a great influence on the processes of hormone production. The neurosecretory cells of the regulatory system respond to the production of neurohormones.

The main functions of Liberians

These are the releasing hormones of the hypothalamus. Perform regulatory functions. Gonadoliberins normalize the functioning of the sexual sphere of women and men.

They are responsible for the reproduction of follicle-stimulating hormones and affect the work of the testicles and ovaries.

A component such as lyuliberin exerts a deterrent effect on ovulation, forming the possibility of conception of the fetus.

Women who are indifferent to intimate life, lyuliberin and follberine are produced in insufficient quantities.

There are also releasing factors related to the average proportion of the hypothalamus, but their connections to the pituitary and adenohypophysis elements have not been studied.

Agonists of the releasing hormone: drugs

As already noted, these hormones produce the hypothalamus. When it is required to stimulate the ovaries, for example before the IVF procedure, agonists or analogs of the releasing hormones are used. That is, they have on the body the same action as your own hormone.

But the probability of development of adverse reactions from the female organism is great. This is due to a decrease in the level of estrogen. The most frequent phenomena include:

• headache;
• Excessive sweating;
• Tides;
• Dryness in the vagina;
• Mood swings;
• Depressive states.

The following medicines are used:

• "Diferelin" is an artificial decapeptide, an analogue of the natural releasing hormone.
• "Decapeptil" in the composition has triptorelin, an artificial analogue of GnRH. The half-life is longer. Often used in artificial insemination.
• "Lyukrin-depot" is leuprorelin. It has anti-estrogenic, anti-androgenic action, treats endometriosis, hormone-dependent tumors - prostate cancer, uterine fibroids. "Lyukrin-depot" lowers the concentration of testosterone in men, estradiol in women, in addition, inhibits the growth of the pituitary gland FSH, LH.
• The effect of the drug gradually restores the physiological secretion of hormones.
• "Zoladex" is a synthetic analogue of the natural releasing hormone (LH). Often used in IVF. Reduces the concentration of estradiol in the blood, this is due to the suppression of LH secretion of the anterior lobe of the pituitary gland.
  

We reviewed the agonists of the releasing hormone.

Antagonists

Since the reception of the releasing hormone agonists is extremely increased estradiol, a sharp release of luteinizing hormone can occur. This leads to premature ovulation and death of the oocytes. To prevent this from happening, antagonists of the releasing hormone are used. As a result of their action, the pituitary gland can be stimulated again. The ovarian hyperstimulation syndrome does not manifest itself, and it has often happened because of prolonged use of GnRg agonists. Enter five days after starting the use of follicle-stimulating hormone.

In order for the therapy to be successful, only the specialist should prescribe all the prescriptions.