"Exxhol": instructions for use, reviews, photo, form, composition

In our body there is a unique organ, capable of recovery - it's the liver. Under the influence of various adverse factors, this gland experiences enormous loads, and its cells die or degenerate into adipose tissue. A number of drugs are used in the treatment of the liver, one of which is Exhole. Instructions for use of this medication, indications, contraindications, features of therapy and other useful information are described in this article.

Form of issue and composition

This preparation is available in the form of capsules, each of which contains an active substance - ursodeoxycholic acid in an amount of 250 mg, as well as auxiliary components: silicon dioxide, magnesium stearate, calcium hydrogen phosphate dehydrate, povidone, lactose monohydrate and others.

How does the drug work?

Features of the pharmacological effects of the drug "Exhol" instructions for use describes as follows: a hepatoprotective drug with choleretic effect. The active substance has the following effects:

• Reduces the synthesis of cholesterol in the liver, reduces its absorption in the intestine and the content of bile;
• Increases the quality of dissolution of cholesterol in the bile excretion system, stimulating the formation of this secret and decreasing its lithogenicity;
• Stimulates a rise in the level of bile acids;
• Increases the secretion of gastric and pancreatic secretions;
• Increases the activity of the lipolytic enzyme;
• Has a hypoglycemic effect;
• Stimulates partial or complete resorption of cholesterol-type stones;
• Reduces the saturation of bile with cholesterol, mobilizing it from stones;
• Has the properties of the immunomodulator, regulating the response mechanisms in the liver;
• Reduces the expression of antigens concentrated on the membrane system of hepatocytes;
• Regulates the number of T-lymphocytes, interleukins-2;
• Reduces the number of elzinophils.

What is the pharmacokinetics of the drug?

The drug "Exhol", the instruction for use of which is described in this article, is characterized by a high degree of absorption in the small intestine and the ability to penetrate the placenta. The maximum concentration of drug in the blood is reached after 1-3 hours and equal to 5.5 mmol / l. Ursodeoxycholic acid binds to a large extent with plasma proteins and is metabolized in liver cells into taurine and glycine conjugates that are secreted into bile. The exchange products are deduced from the calves by 50-70%. A small amount of unchanged active substance enters the intestine, where it is transformed by bacteria into lithocholic acid, which is sulfated in the liver and completely eliminated from the body by the intestine.

Who is receiving the drug?

Direct indications for taking the drug "Exhol", the instruction for use calls the following states:

• Biliary cirrhosis of primary type with absent signs of decompensation;
• The need for dissolution of cholesterol stones of small and medium size, provided that the gallbladder functions;
• Gastritis (biliary reflux);
• Active chronic hepatitis;
• Liver disease with alcoholism;
• Sclerosing cholangitis of the primary form;
• Cystic fibrosis of the liver;
• Steatohepatitis of non-alcoholic nature;
• Diskenzia bile ducts.

With these indications, the capsules and Exoll tablets are often prescribed by a doctor and demonstrate high efficacy.

Contraindications

The drug containing ursodeoxycholic acid is contraindicated in the following diseases:

• The presence of hypersensitivity to the components of the drug;
• Lack of normal function, as well as empyema of the gallbladder ;
• The presence of stones with a large proportion of calcium, detected by x-rays;
• Fistula in the digestive tract;
• Chronic hepatitis;
• An inflammatory bowel disease;
• Cholecystitis or cholangitis in the acute stage;
• Decompensated cirrhosis of the liver;
• Infection of the gallbladder, its ducts and intestines;
• Pregnancy and lactation;
• Children under 3 years;
• Renal and hepatic impairment;
• Obturation of ways of a conclusion of bile.

If these contraindications are present, it is not recommended to prescribe the drug "Exhol" to patients. The instruction indicates that this remedy did not have a negative effect on the fetus when studied on animals, however, adequate studies were not carried out in pregnant women.

special instructions

Specifically points to some of the nuances of taking Exxhol medication instructions for use. The doctors' comments about this drug are positive, but they draw the attention of women of childbearing age to the fact that in the treatment of this drug should take care of additional contraception. In addition to hormonal contraceptives, the effectiveness of which is reduced, barrier methods of protection against unwanted pregnancy should be used. It is not recommended to thinklessly prescribe to pregnant women treatment with Exhol. The instruction indicates that in this situation the risk to the mother should be higher than the risk to the fetus. When taking this medication with a woman, lactation should be stopped.

If the child has reached the age of 3, then, if necessary, he may be prescribed the drug "Exhol". Instructions for use for children call for caution in treating babies under 4 years old, since they may have trouble swallowing the capsule.

How to apply the medicine?

The best guide to the treatment with Exxhol is the instructions for use. The photo of this tool will help you to protect yourself from buying counterfeit.

The drug is taken orally, preferably in the evening. It is not recommended to chew capsules, it is better to wash it down with water in a small amount. If the patient weighs less than 34 kg, then it is better to prefer a suspension with the same drug substance.

The dosage of the drug depends on the age and purpose of the therapy.

For the purpose of splitting the stones in the gallbladder and ducts, Exoll is taken at a daily dose of 10 mg / kg for 6-12 months and several months after the result is achieved for prevention.

If the patient is treating reflux gastritis, he is prescribed one capsule of the drug once a day during the cycle from two weeks to six months, and if necessary, up to 24 months.

Treatment of biliary cirrhosis is performed according to the scheme: per day - 10-15 mg / kg with duration at the doctor's discretion.

With other diseases included in the list of indications for admission, the dosage of the drug and the duration of its administration are determined by the doctor on an individual basis.

Also, a special approach requires the appointment of children and adolescents "Exhol". Instructions for use in children older than 3 years indicates the need to prescribe a dosage of 10-20 mg / kg of body weight per day. Exact rationing of the drug and the duration of therapy is established by the doctor individually.

Do they cause side effects and overdoses?

At the time of taking Exxol, side effects may occur, such as:

• Pain in the back;
• Digestive disorders;
• Increased liver transaminase activity;
• allergy;
• Calcium saturation of gallstones;
• Recurrent psoriasis;
• Alopecia.

If these effects occur, stop taking Exoll. The instructions for use, the composition of which is summarized in this article, indicates that there have been no cases of an overdose of this medication. However, if a patient has symptoms of intoxication, symptomatic therapy is necessary.

Combination with other medicines

Joint reception with aluminum-containing antacits and ion-exchange resins decreases the efficiency of absorption of "Exhol". Lipid-lowering drugs, neomtsin, estrogens or progestins contribute to increased bile cholesterol saturation and reduce the dissolution of stones.

Features of reception means

The first document that you must read before taking Exxol is the instructions for use. The form of release of this drug in the form of capsules is most effective against fully cholesterol stones, whose size does not exceed 15-20 mm. In this case, the gallbladder should be filled with these formations by not more than half, and the ducts retained their function to the excretion of bile by 100%.

In the process of therapy aimed at dissolving cholesterol deposits, it is required to control the activity of liver enzymes: transaminases, alkaline phosphatase, GGT and bilirubin. Once every 4 weeks, every 3 months of therapy should be performed cholecystography. Every six months the patient should undergo ultrasound of the liver to assess the effectiveness of treatment.

When full splitting of the stones was recorded, the "Exhol" should be taken for another three months to finally dissolve the invisible concrements and prevent the formation of new ones.

If in the first six months or a year of treatment there is not even a partial dissolution of stones, this means that it is not advisable to continue treatment because of its ineffectiveness.

Analogs and synonyms

If the patient for any objective reason can not be assigned Exoll, then it can be replaced by one of the synonyms:

• Capsules "Ursodeoxycholic acid";
• Capsules "Ursoliv";
• Capsules "Ursosan";
• Tablets with a film shell "Ursodex";
• Capsules by "Ursoron Romparm";
• Capsules of "Urdoks";
• Suspension for internal reception "Ursofalk";
• Ursofalk capsules;
• Capsules "Ursolit";
• Tablets with a film membrane "Livedoksa";
• Capsules "Grinterol"

If the patient is experiencing an individual intolerance to ursodeoxycholic acid, or if it has shown its ineffectiveness in treatment, then it is possible to replace this drug with an analog, which is the tableted form "Holenzyme". This drug is a combined remedy consisting of dry bile, powdered dihydrated pancreas and mucous tissues of the small intestine of livestock. According to the action "Holenzyme" refers to cholagogue. This drug is contraindicated in hypersensitivity, acute and acute chronic pancreatitis. As adverse reactions from taking this medication, allergic reactions may occur in the form of lacrimation, flushing and skin rashes.

Cost and patient feedback

This drug is produced by the domestic pharmaceutical company ZAO Kanofarma Production, which is located in the Moscow region. The cost of packing "Exhol" on average in Russia is 125 rubles. Many patients note the effectiveness of this medication, the convenience of its administration and affordable price. People who have diseases of the liver and bile ducts notice that good results have been achieved with the treatment of "Exhol". Together with the effectiveness of patients noted good tolerability of this tool.

It is worth noting that the description of this drug is incomplete. To obtain detailed information about the drug "Exhol", you should read in detail the instructions contained in the package containing the medicine. The appointment of this tool is only the attending physician. Self-medication can be dangerous to your health.