Bonviva: reviews. Bonviva: instructions for use, price

Imperceptibly and rapidly the years go by. Until recently, the young girl proudly walked along the street with a certificate of graduation. It seems that a little time has passed, and a young mother is already escorting her children to school. Years passed, and, please, my grandchildren are already growing up. Autumn of life ... It is at this age and overtook a woman such a formidable disease as postmenopausal osteoporosis. This disease is very fragile and prone to fractures become bones. The modern pharmaceutical market is ready to offer its consumers a fairly large list of drugs that will successfully help to cope with this formidable disease. One of the most modern medicines is the drug "Bonviva".

Mechanism of influence

The main active substance of the drug is ibandronic acid. This component prevents and inhibits the process of destruction of bones. In addition, this substance effectively inhibits the process of bone resorption (resorption), but without directly affecting the formation of bone tissue. In addition to ibandronic acid, the preparation as an auxiliary component includes plasdon K-25, lactose monohydrate, crospovidone, stearic acid, aerosil.

"Bonviva" medication instructions for use describe how to slow the renewal of bone tissue in patients during the menopause to the level at which they are in a woman of reproductive age. As a consequence, the bone mass and mineral density of bones are actively increasing, the characteristics of splitting of bone collagen are reduced. In general, ibandronic acid is a highly effective substance with a wide therapeutic range. For this reason, "Bonviva" can be used for periodic treatment and is characterized by sufficiently flexible dosing capabilities.

Medical reviews ("Bonviva" has already gained a good reputation in the pharmaceutical market) suggest that the drug is absorbed quickly enough in the gastrointestinal tract. After a period of time from 30 minutes to 2 hours in plasma, its maximum concentration is achieved. From blood, the preparation in the volume of 40-50% of the total amount taken penetrates into the bone tissues and there is accumulation. Still some part of the medicine is associated with blood plasma proteins. All the rest will be excreted from the body by the kidneys.

According to clinical studies, the main component of "Bonviva" equally affects men and women. There are no obvious differences in the distribution of ibandronic acid between representatives of the European and Asian races. In patients of African descent, there are some differences in the distribution of the active substance "Bonviva".

Main Customers

The Bonviva tablets are available in three dosages: 2.5 mg, 50 mg and 150 mg. The drug in a dose of 2.5 mg is mainly used for the treatment and prevention of postmenopausal osteoporosis in women. Medication at a dosage of 50 mg is used in a much wider range of diseases. The main areas of therapeutic therapy include diseases such as metastatic damage to bone tissue (the drug should minimize the risk of hypercalcemia), fractures of pathological nature. Tablets in this dosage can also weaken the pain syndrome, reduce the need for radiotherapy procedures for pain and fracture threats. Such doses are used to treat patients with hypercalcemia on a background of malignant neoplasms.

Tablets of 150 mg are the most popular consumer medicine "Bonviva". Instructions for use (the price is quite high, but this dose should be taken once a month, which is very convenient) regulates the use of a pill to prevent fractures in postmenopausal osteoporosis in women. Clinical studies have shown that taking a single dose of 150 mg is as effective as daily use of 2.5 mg tablets per month.

In addition to the above, one more widely used is another form of the drug "Bonviva" - injections. In most cases, the admission scheme is as follows: 1 injection at 3 months. I must say that the injection "Bonvivan" is quite aggressive, therefore, when treating this form, you can expect any side effects. Before direct application, the solution should be visually checked for impurities, pay attention to its coloration.

The drug is injected intravenously, struino, for 30 seconds. The procedure is performed only by a medical professional. When it is carried out, you should avoid getting the solution inside the artery and in the tissues surrounding the vein.

Application Features

Patients suffering from osteoporosis, experts usually prescribe to take 1 tablet (dosage - 150 mg) once a month. However, it is necessary to adhere to certain rules of reception, so that the drug "Bonviva" acted as effectively as possible.

The drug is very poorly absorbed if its reception is combined with a meal or with a drink (the exception is simple still water). As mentioned earlier, "Bonviva" tablets are taken one time a month. But it is very, very desirable for the drug to be taken on the same day. If, for any reason, the day designated for taking the medication has been missed, then the pill must be taken at least within the next week. If this condition could not be met, then the reception should be postponed till the appointed day of the next month. Simply put, it is strictly unacceptable to use 2 tablets with a dosage of 150 mg for one week.

Take medication should be at least 60 minutes before eating or drinking anything. To chew or dissolve tablets is not recommended, they must be swallowed whole and washed down with a glass of clean water (not mineral and not aerated). After the medicine was taken, it is impossible to lie for 1 hour, the body should be in an upright position.

Contraindications to the admission of "Bonviva"

Like any other medication, Bonviva instructions for use (the price of the drug will be listed below) does not recommend taking patients who are hypersensitive to the components of the drug or even intolerance to them. Medical specialists never prescribe medication to patients suffering from such diseases as ahalasia and stricture of the esophagus, hypocalcemia, glucose-galactose malabsorption. It is inadmissible to use drugs with people who are intolerant to galactose, lactose deficiency. Do not prescribe (despite the positive feedback) "Bonviva" to children and adolescents suffering from osteoporosis.

Very carefully, doctors prescribe the drug to patients who have problems with the gastrointestinal tract (ulcer, duodenitis, gastritis, dysphagia, Barrett's esophagus). In addition, any acute pathological processes in the stomach and esophagus should be the basis for discontinuing the drug or, at a minimum, consulting a specialist.

The medicine "Bonviva" (injections, tablets - any form of release) is not shown for pregnant women. The reason for this is the lack of clinical experience.

Overdose, side effects

After taking the first pill, some patients may experience mild flu-like symptoms. Adoption of any special measures in this case is not required.

If the allowable dose is exceeded, certain side effects may occur. From the side of the gastrointestinal tract there can be such manifestations as diarrhea, dyspepsia, ulcer, duodenitis, gastritis. Quite often, "Bonviva" (instruction, patients' testimonials to prove this) can provoke nausea, vomiting, abdominal pain, flatulence, dysphagia. With such manifestations, relative antidotes can be considered milk and antacids. It is impossible to try to induce vomiting in order to avoid the risk of damaging the esophagus mucosa.

The musculoskeletal system can respond to the medication with muscular stiffness and spasms, myalgia, arthralgia. In rare cases, the risk of osteonecrosis of the jaw is increased against the background of oncological diseases. Therefore, the dentist should be informed that his patient is taking Bonviva to assess the benefit / risk ratio and making a decision about the expediency of surgical intervention at this stage of the treatment course.

Dizziness and a headache can respond to the "Bonviva" nervous system. In addition, a number of allergic manifestations are possible, such as hives, skin rashes, swelling of angioedema. There may be weakness, back pain. You should be aware that non-compliance with the dosing regimen can increase the likelihood of side effects from the digestive system.

Pre-treatment course

Before starting any dosage of the Bonviva preparation, instructions for use (the price depends on the form of release and dose) recommends paying attention to the level of calcium in the body. If there are manifestations of hypocalcemia, any other deviations from the norm of bone tissue metabolism and electrolyte balance, potential consumers of Bonviva should take Ca ²⁺ and vitamin D in sufficient quantities. Taking other bisphosphonates quite often provokes irregularities in the swallowing process, The development of esophagitis, the formation of ulcerative foci in the stomach and esophagus. To minimize these unpleasant manifestations, it is necessary to strictly follow the recommendations (the vertical position of the body within 60 minutes after the application of "Bonviva").

If signs of esophageal lesions are found with the "Bonviva" preparation, the instructions for use (patients' testimonies to prove this) advise stopping the medication and consult a doctor.

During the course of therapy with the drug "Bonviva" the patient's diet should be rich in vitamin D and calcium. If there is no possibility to fully feed and ensure the intake of calcium and vitamin D with food, you must definitely take the appropriate drugs.

Analogs

Currently, the most common drugs - analogues of "Bonviva" - is "Bandronat" and "Ibandronic acid Sandoz." They are analogues for the main active substance. A group of drugs close to Bonviva on the mechanism of action is much broader. This includes the following drugs: Bonefos, Alental, Veroclast, Zolerix, Lindron, Ostealen, Rizendros, Forosa, and Fosamax. In order to replace the prescribed drug with the equivalent of Bonviva (price, consumer reviews are not sufficient grounds), it is necessary to consult with the attending physician or pharmacist.

Price range

Despite the fact that "Bonviva" in tablets is produced by manufacturers in three dosages (2.5 mg, 5 mg and 150 mg), the tablet with a maximum dose of 150 mg is the most popular consumer demand. This dose is convenient for taking (once a month), however, the drug is not cheap. 1 tablet can be purchased in the pharmacy chain for the amount ranging from 1650 rubles to 2120. The rest of the tablet form is not in great demand, therefore it is rather problematic to find them in pharmacies.

Bonniva injections also gained a reputation in the pharmaceutical market and find their buyer. Injections are even more not burdensome for a patient than tablets with a dose of 150 mg: an injection according to the standard scheme is done once in 3 months. However, this form of release of the drug will cost the buyer a much more impressive amount than tablets. For 1 syringe tube for intravenous injection with a dose of 3 mg of Bonviva, the price in pharmacies can range from 5525 rubles to 5950.

Consumer opinion

Despite the rather wide popularity of the drug "Bonviva" (instructions for use, the price - I must say, considerable - to that confirmation) reviews about the drug have different directions. Both positive and negative. A small group of patients says that the next day after the injection, the pain syndrome manifested itself clearly: the whole body ached, muscles contracted, and the spine ached. Some have rashes on the skin.

Quite often you can hear from patients that after taking an unpleasant sensation it reminds oneself of the gastrointestinal tract. However, pain rarely reaches some critical values, when special therapy is required to eliminate them. The positive effect of "Bonviva" compensates for the reaction of the gastrointestinal tract.

Also there are positive reviews, "Bonviva" in which acts simply as a panacea for fragility and brittle bones. Very many patients notice obvious changes for the better from the bone tissue. In many people, the back practically stopped hurting, the stoop decreased, the gait became more confident and easier. And even those patients whose subjective sensations did not change anything after the examination were convinced that the bone tissue was compacted.

Still patients are very happy with the regimen of taking the drug. Despite the fact that the price of "Bonviva", as they say, bites, it is very convenient - to take one pill and forget about the treatment for a whole month. The same can be said about the injections (once in 3 months). The main thing is not to forget about taking the next dose.

Some patients draw attention to the fact that at the very beginning of the treatment, the medicine Bonviva had a condition similar to that seen with influenza infections. However, it quickly passed, and, what to say, in comparison with the threat of osteoporosis, such conditions are minimal troubles.

Some patients, whose "Bonviva" reviews, although they deserve only positive, say that a parallel reception with this "Calcium D3" Had a negative effect on the digestive system.

Summarizing

Bonviva is a modern and very effective drug designed to prevent the development of osteoporosis and the destruction of bone tissue. Despite the iridescent about the drug Bonviva (the instruction, the price of which was reviewed in the review), reviews already taken this medication of patients, it should be remembered: the only reason for initiating therapy is the instructions of the attending physician. It is important to find a doctor who will be very attentive to assessing the state of health of his patient and will correctly select the dosage regimen. Only in this case, the risks of side effects will be minimized, and the drug will prove to be a highly effective agent for the treatment of osteoporosis and preservation of bone tissue strength.