What helps "Nize" (tablets)? Instructions for use, analogues

Do you know what helps "Nize" (pills)? If you do not possess such information, we will present it in the materials of this article.

Packaging of the preparation and its composition

About what helps "Nize" (tablets), we'll tell you below. The active ingredient of this drug is nimesulide. Also in its composition it includes such components as microcrystalline cellulose, aspartame, calcium phosphate, colloidal silicon dioxide, corn starch, magnesium stearate, sodium carboxymethyl starch, pineapple flavor and talc.

For sale, the drug in question comes in blisters of 10 tablets, packed in packs of cardboard.

Principle of action of a medicinal product

Before answering the question of what helps "Nize" (tablets), you should tell us how this drug works.

According to the instructions, this is an NSAID that selectively inhibits COX-2, that is, an enzyme involved in the synthesis of prostaglandins, mediators of pain, inflammation, and edema. In addition to anti-inflammatory properties, the drug in question exhibits antipyretic and analgesic effect.

It should also be said that this medicine inhibits (reversibly) the formation of prostaglandin E2 in the ascending pathways of the nociceptive system and the inflammatory focus, and also in the ways of impulses (painful ones) in the spinal cord.

The preparation "Naise", analogues of which are listed below, reduces the concentration of prostaglandin H2 (short-lived), from which, under the influence of prostaglandin-isomerase, prostaglandin E2 appears. Reduction of the concentration of the latter leads to a decrease in the degree of activation of EP-type receptors (prostanoid), which is expressed in anti-inflammatory and analgesic effects.

It should also be noted that, to an insignificant degree, the drug in question affects COX-1. Under physiological conditions, it almost does not prevent the occurrence of prostaglandin E2 from the arachidonic acid. This reduces the number of side effects of the drug.

The main properties of the drug (NSAIDs)

The drug "Naise" is able to suppress the aggregation of platelets. This occurs by inhibiting the synthesis of thromboxane A2 and endoperoxides. In addition, it suppresses the release of histamine, and also reduces the degree of bronchospasm, which was caused by the effects of acetaldehyde and histamine.

Specialists have shown that nimesulide inhibits the synthesis of urokinase and interleukin-6, preventing the destruction of cartilaginous tissues. In addition, it inhibits the synthesis of metalloproteases, preventing the destruction of collagen and proteoglycans.

According to the instruction, by reducing the activity of myeloperoxidase, the drug in question exhibits antioxidant properties and slows down the formation of products of (toxic) O ₂ decay. It interacts with glucocorticoid receptors and activates them, which contributes to the enhancement of anti-inflammatory action.

Kinetics of the drug

After ingestion, the anesthetic "Naise" is absorbed from the intestine. Eating reduces the rate of absorption of the drug, but does not affect its degree.

The peak concentration of nimesulide in the blood is reached after 2.6 hours. Its connection with proteins reaches 95%.

This drug penetrates into all tissues of the female genital organs. In addition, it is found in the acidic environment of the focus of inflammation and synovial fluid.

Metabolism of nimesulide is carried out in the liver. Its half-life is 5 hours. It is excreted mainly by the kidneys, and also along with the bile.

Indications for taking tablets

What helps "Nize" (tablets)? The considered means are appointed at:

• Radiculitis, rheumatoid arthritis, sciatica;
• Lumbago, osteoarthritis, articular syndrome with rheumatic fever and exacerbation of gout;
• Psoriatic arthritis, arthralgia, ankylosing spondylitis;
• Arthritis of various origin, osteochondrosis with radicular syndrome;
• Inflammations of ligaments, myalgia of non-rheumatic and rheumatic genesis, bursitis, inflammation of tendons;

• Pain syndrome of various origin (including trauma, postoperative period, toothache, algodismenorrhea, headache);
• Inflammations of the musculoskeletal system, as well as soft tissues.

Also it should be noted that the "Nyz" helps the temperature well. This drug is used for fever of various origin, including inflammatory and infectious diseases.

Contraindications NSAIDs

The drug "Naise" during pregnancy is prohibited. Also it should not be used when:

• The "aspirin triad";
• Erosive and ulcerative lesions of the gastrointestinal tract (with exacerbation);
• Breastfeeding;
• Bleeding from the gastrointestinal tract;
• Impaired liver function;
• In childhood up to two years;
• Renal failure expressed;
• Hypersensitivity.

With special care this drug is prescribed for type 2 diabetes, arterial hypertension and cardiac insufficiency.

How to accept "Nize"?

The medicament in question in the form of tablets is administered only orally. Adult patients are recommended to take 100 mg twice a day. The maximum dosage of the drug per day is 400 mg.

As for dispersible tablets, before taking this medication, it should be previously dissolved in 5 ml of ordinary water (in 1 dessert spoon). Use this remedy at the end of the meal or after eating.

Children do not prescribe the drug in tablets. For them, there is another form of medication - a suspension. It is recommended to take it at the age of two years.

Occasional phenomena

The drug "Naise", the dosage of which was presented above, can cause such undesirable reactions as:

• Heartburn, toxic hepatitis, nausea, thrombocytopenia, vomiting;
• Agranulocytosis, pain in the stomach, anemia, diarrhea, leukopenia;
• Erosive and ulcerative lesions of the digestive tract, headaches, increased activity of liver transaminases;
• Anaphylactic shock, dizziness, skin rash;
• Prolongation of bleeding time, bronchospasm, hematuria, fluid retention.

Cases of overdose

What are the symptoms when taking a large number of Nize tablets? The dosage of this medication should be determined by the attending physician. If the medicine is accidentally swallowed (in large quantities), the patient may develop the following symptoms: convulsions, increased blood pressure, irritation of the gastrointestinal mucosa, impaired renal function, hepatic impairment and respiratory depression.

To eliminate such conditions, the patient is washed with a stomach, prescribed activated charcoal and conducts symptomatic therapy.

Drug Interactions

With the simultaneous oral administration of Naise with diuretics, digoxin, phenytoin, antihypertensive agents and lithium, as well as with other NSAIDs, cyclosporine, anticoagulants, methotrexate, hypoglycemic medications (oral), the patient may experience drug interaction For competing these drugs for binding to proteins).

"Naise": analogues and reviews

You can replace the remedy with such medications as Nimulide, Aponil, Arkoksia, Mesulid, Meloksikam, Nimesil, Movalis, Nimesulid, Denebol, Nimika.

Most of the consumer feedback on the drug in question is positive. According to their opinion, "Nize" is quickly relieved of pain, and the drug is also used as a highly effective anti - inflammatory drug. Although some patients claim that this medication has one significant disadvantage. It very often causes such adverse reactions as dizziness, weakness and problems with the digestive system. In this case, doctors recommend that you replace the drug with a similar remedy.