Detailed instructions "Futsisa": indications for use, analogues and reviews

Along with antibiotic agents, antifungal agents also effectively help patients get rid of diseases that have been caused by microorganisms sensitive to their active substance.

Currently, there is a huge number of such medicines. Their pharmacological characteristics often coincide. But most often, experts appoint their patients a drug such as "Futsis." Instructions for use and features of this tool will be presented in the materials of this article.

Composition, shape and packaging

The medicinal preparation "Futsis", the instruction to which is enclosed in a pack of cardboard, can be purchased in the form of tablets. Their active ingredient is fluconazole. Also, the composition of the medicament includes and auxiliary components.

The given preparation is issued in doses of 50, 150, 100 and 200 mg. Tablets, in an amount of 4 pieces, are packed in a blister and a cardboard bundle, respectively.

In what other form can you buy "Futsis"? Instructions for use (tablets - this is not the only form of this remedy) reports that this medication is also available as a solution for infusions. The composition of the tablets includes fluconazole and additional ingredients such as microcrystalline cellulose, povidone K30, lactose, talc, magnesium stearate, sodium croscarmellose, sodium starch glycolate and others.

The solution for intravenous injections goes on sale in bottles of 100 ml.

As for the gel "Fucis", it can be bought in tubes of 30 g.

Pharmacology of a medicinal product

What are the peculiarities of Fucis? Instruction for use states that each form of said agent has a pronounced antifungal effect.

Fluconazole is a synthetic derivative and belongs to the group of thiazole compounds. This substance helps to eliminate the enzymatic activity of specific components that are found in fungal cells.

After application of the preparation, the biological synthesis of sterol compounds is disrupted, and the process of converting lanosterol to ergosterol is inhibited. Such changes in cell membranes help stop the reproduction of fungi.

Properties of the medicine

What are the properties of the drug "Futsis"? Instructions for use (tablets have the same pharmacological characteristics as solution and gel) states that this drug is characterized by low toxicity. In this regard, it does not have a negative effect on the human body, as well as a significant impact on cytochromes and the amount of androgenic hormones in the blood plasma.

Pharmacokinetics of the drug

The instruction of "Futsis" says that after taking the tablets inside they are quickly and well absorbed from the digestive tract. According to experts' reviews, fluconazole has high bioavailability. Eating does not have any effect on the absorption process of this product.

The maximum concentration of the active substance in the blood plasma is observed after about 60-90 minutes after administration.

The medicament in question quite well penetrates into the composition of biological fluids and tissues. Also fluconazole passes through the blood-brain barrier and is concentrated in the cerebrospinal fluid.

Removal of the drug from the patient is carried out together with urine. Its half-life is approximately 30 hours.

What kinetic parameters does the "Fucis" solution have? The instruction states that the pharmacokinetics for intravenous administration of the preparation is almost not different from the oral administration.

As for the antifungal agent in the form of a gel, it has the same characteristics and activity. Especially effectively, the gel manifests itself in dermatophytes and yeast.

During the external application of this agent, only a small amount of its active substance enters the blood. In this regard, its systemic effect is completely excluded.

Also, specialists have found that the gel does not adversely affect the skin condition.

Indications for use

The instruction of "Fucis" informs that this preparation is very often used in the treatment of infectious diseases of different localization, which were caused by microorganisms that show high sensitivity to fluconazole. As a rule, the medicine is prescribed by gynecologists, dermatologists and mycologists.

So when should you use the drug "Fucis" (tablets)? The instruction says that this form of medicine is prescribed when:

• Therapy of mycoses that appeared on the feet and in the groin, onychomycosis, dermatomycosis and pityriasis;
• Infections on the mucous membranes, which were caused by fungi of the genus Candida;
• Candidiasis infections of different localization (for example, with candidemia, disseminated candidiasis, candiduria and other forms of generalized candidiasis that were caused by Candida fungus);
• Bronchopulmonary non-invasive candidiasis infections;
• Treatment of chronic and acute forms of vaginal candidiasis (recurrent);
• Chronic candidiasis of the oral mucosa, which is associated with the wearing of removable dentures;
• Treatment of histoplasmosis, sporotrichosis and other endemic mycoses.

What other purpose can the oral preparation "Fucis" (tablets) be prescribed for? The instruction says that this medication is often used to prevent relapses in patients with:

• Candida balanitis;
• Vaginal chronic candidiasis;
• Cryptococcal infections of different locations;
• Fungal infections of different locations, if the patient suffers from immunodeficiency or receives cytostatic, as well as radiation therapy.

As for the solution for infusion introduction, the instruction "Fucis" indicates that this form of the drug is used in the treatment:

• Cryptococcal meningitis;
• Systemic fungal infections (candidemia, candidal infections of the eyes, candiduria, endocardium);
• Cryptococcal infections of the skin and respiratory system.

A medicament for external application can be prescribed for:

• Dermatomycoses that cause yeast;
• Dermatophytes (inguinal epidermophytia, epidermophytia of feet, trichophytias, multicolored lichen and candidal infections).

Contraindications for use

And what is the scheme of treatment with the drug "Futsis" for children? The instruction says that this tool for adults and toddlers is not recommended for use with increased individual sensitivity to the elements of the medication. Also, it is not used in the presence of allergies to azole compounds that are close in structure to fluconazole.

At what age do they purchase Fucis DT for children? The instruction informs that usual tablets are extremely contraindicated for the treatment of babies under 7 years, and dispersed - up to 3 years.

Also, the medication in question is prohibited for use during pregnancy and breastfeeding. It is not used to treat people receiving therapy with "Cisapride" and "Terfenadine", and those whose work is related to the management of vehicles and potentially dangerous mechanisms.

Fucis DT: instructions for use

Medication in the form of tablets, as well as in the form of a solution and gel should be used in different ways.

How should I take Fucis 50? The instruction says that a drug with an active substance content of 50-200 mg is used to treat not only adults, but also small patients from 3-7 years.

Tablets are taken at any time of the day orally. The daily dosage of the drug is designed for a single dose and is set only by the doctor (depending on the disease).

How to use the dispersed Fucis tablets (50 mg)? The instruction informs, that before reception of the given preparation it should be preliminary dissolved in usual water (about 5 ml).

For people suffering from genital candidiasis, the drug in tablets is prescribed once in an amount of 150 mg. To prevent recurrence of chronic vaginal candidiasis (thrush), the medication is used in the same dose, but only once a month.

Typically, the dosage of the agent in question does not depend on its method of administration, nor does it change when passing from parenteral administration to oral administration.

Method of application of the infusion solution

The instruction of "Fucis" informs that the drug for intravenous administration contains 200 mg of fluconazole, as well as 100 ml of a solution of sodium chloride (isotonic).

Before administering the medication, the patient should limit the intake of water and sodium. It is also necessary to take into account the content of ions of chlorine and sodium in the solution.

Despite the absence of severe drug incompatibility, the agent should not be confused with other infusion preparations.

Application of gel

Gel "Futsis", like tablets, must be used once a day. The external agent gently rubs into the affected skin areas, as well as the areas around them.

Specialists report that to achieve therapeutic effect, the patient requires only a small amount of gel. It is carefully ground over the entire surface of the fungus affected area in order to prevent the development of maceration.

Now you know how to use the gel, solution and Fucis tablets (150 mg). The instruction says that the dosage, as well as the duration of application of each of the presented forms should be determined only by the attending physician.

Adverse events

What side effects can the application of the infusion solution, gel and tablets "Fucis 150" cause? The instruction says that against the background of using these funds, the following unwanted reactions can develop in the patient:

• Severe headaches, tremors, dizziness and convulsions;
• Arrhythmia and tachycardia;
• Nausea, abdominal pain, vomiting, digestive disorders, diarrhea, and others;
• Allergic reactions on the skin in the form of alopecia, toxic epidermal necrosis, itching, skin rash, urticaria, swelling, Stevens-Johnson syndrome.

Also, the use of this drug can affect the indices of laboratory tests (neutropenia, leukopenia, agranulocytosis, hypokalemia, thrombocytopenia, triglycerides and cholesterol level in the blood).

These side effects require the immediate cessation of Fucis.

Cases of overdose

When an overdose of a solution or Fucis tablets, the patient may develop such negative symptoms as dizziness, headache and hallucinations. In addition, one can not exclude the paranoid behavior of a person.

In case of an overdose, the victim is washed with a stomach and carries out symptomatic therapy.

Compatibility of the drug with other medicinal products

Simultaneous application of the solution and Fucis tablets with anticoagulants significantly enhances their effect. In this regard, constant monitoring of prothrombin time is required .

The drug in question can increase plasma concentrations of "Benzodiazepine", "Midazolam", "Cyclosporine", "Phenytoin" and "Rifabutin" in the blood. When flukanozole is combined with any of the above, it is necessary to adjust the dose of the drug and observe an experienced specialist. If you neglect this advice, then such combinations can enhance side effects, cause the development of psychomotor reactions, and so on.

With the regular use of hydrochlorothiazide with Fucis, a significant increase in the concentration of fluconazole in the blood can be expected. However, this does not require correction of dosages.

Taking this medication does not reduce the effect of oral combined contraceptives.

In the process of therapy "Fucis" patients with diabetes should take into account the likely development of hypoglycemia.

Simultaneous reception of this drug with "Rifampicin" requires an increase in the dose of fluconazole.

The combination of "Fucis" and "Tacrolimus" very often causes a mutual increase in their nephrotoxicity.

Cost and analogues of an antifungal agent

After the appointment of the antifungal drug "Fucis" many patients ask the question about how much it costs. It should be noted that the price of this drug in different pharmacy chains may vary slightly. Its average cost is about 300-400 rubles (regardless of the form of release).

Drugs similar in pharmacological characteristics include such drugs as "Fluconazole", "Fukortsin", "Clotrimazole" and "Livarol". However, when taking them, it is necessary to take into account that they can have completely different contraindications and side effects. Therefore, to replace the "Fucis" with these drugs should always refer to a doctor. By the way, the latter will be able to choose the right and most effective therapy for you.

Patient feedback on an antifungal agent

Most often, the drug is considered positive. According to the latter, it is quite actively used in gynecological practice in the treatment of thrush. However, many people argue that the antifungal agent "Fucis" helps to get rid of this unpleasant disease for a fairly long period of time. However, experts say that we should not forget about additional medications that help restore normal flora in the vagina.

Speaking about the effectiveness of the drug "Futsis", we can not fail to mention negative feedback. Some patients who used this medication note that side effects have been observed with tablets or using a solution. As a rule, they are manifested by swelling, itching of the mucous membranes of the nose and eyes, fever and severe headache.

As for the gel "Futsis", then reviews about it are much less common. In those that are available, it is said about the high effectiveness of this remedy, especially in the treatment of dermatomycosis.