What helps "Famotidine"? Instructions for use, feedback

Do you know about what "Famotidine" helps with? Only the doctor can answer this question. If you do not have time to consult a doctor, we will talk about this drug in this article.

You will learn about the properties of the medication, how much it costs, what diseases it uses, what it includes, and so on.

Composition of the medicinal product, packaging, description and form

In what form do they produce the drug Famotidine? The instruction states that this remedy can be found in the form of tablets. They have a biconvex round shape, as well as a film shell of pale brown or yellow.

What are the ingredients of the "Famotidine" preparation? The composition of this medication is simple: the main substance is famotidine. In addition to the basic substance, this agent contains auxiliary substances, such as microcrystalline cellulose, corn starch, magnesium stearate, talc, silicon dioxide and sodium croscarmellose.

As for the tablet shell, it consists of macrogol 6000, hypromellose, talc, titanium dioxide and a dye of brown iron oxide.

The medicine in question is sold in blisters, which are packaged in paper packages.

It should be especially noted that the drug "Famotidine", the instruction of which is presented below, is available in different dosages - 40 and 20 mg.

Features of the medicinal product

Before answering the question of what "Famotidine" helps with, one should tell how the given drug works. According to the instructions, the agent in question is a H2-histamine receptor blocker. It exhibits anti-ulcer properties.

The main substance of this drug helps suppress the production of basal acid (hydrochloric acid) in the stomach. In addition, famotidine reduces the stimulation of histamine, acetylcholine and gastrin, and also increases the pH of gastric juice, the activity of pepsin and reduces the production of HCL.

Due to the increased level of glycoproteins, this agent increases the formation of gastric mucus and stimulates the synthesis of prostaglandins. Thanks to the secretion of bicarbonate, the wound healing and protective properties of the preparation are achieved.

This drug helps to stop bleeding from the stomach, healing of lesions on its mucous membrane and scarring of stress ulcers.

Properties of the medicament

The drug "Famotidine" (analogs, the price of the medication is indicated below) has a weak effect on the system (oxidase) of the enzyme cytochrome P450 in the liver.

Its effect begins after 65 minutes, lasts about a day.

Kinetics of the drug

The drug "Famotidine", the indications of which are presented below, after oral administration is absorbed from the intestine. Its concentration (maximum) in the blood is reached within three hours.

The association of the drug with plasma proteins is 15-20%. It is excreted with the mother's milk and penetrates the placental barrier.

About 30-35% of the active substance of the drug in question is metabolized in the liver. In this case, the S-oxide is formed.

Elimination of this drug occurs mainly through the kidneys. About 27-40% of the drug is excreted in the urine unchanged. The half-life of Famotidine is 3-4 hours. In people with QC less than 30 ml per minute, this indicator increases to 11-12 hours.

What helps "Famotidine"?

In what cases is the medication prescribed by doctors? According to the instructions, the indications for taking this drug are the following conditions:

• Mastocytosis systemic;
• Prevention of relapses, gastrointestinal tract diseases;
• Reflux-esophagitis;
• Gastroduodenitis erosive;
• Prevention of relapses associated with prolonged use of NSAIDs;
• Zollinger-Ellison syndrome;
• Dyspepsia is functional, which is associated with increased work (secretory) of the stomach;
• Gastrointestinal ulcers are stressful and symptomatic;
• Prevention of aspiration of gastric juice in patients undergoing general anesthetic surgery (ie Mendelssohn syndrome);
• Adenomatosis polyendocrine;
• Prevention of bleeding recurrence, including postoperative period;
• Prevention of pneumonitis aspiration;
• Dyspepsia with pain in the wedge or epigastrium, which occur at night or are associated with the intake of certain foods.

Prohibitions to use the medicine

Now you know what "Famotidine" helps with. But before taking this medicine, you should read his instructions. This medication is contraindicated in the case of:

• Lactation;
• In children under three years of age (with a body weight of less than 20 kg);
• Bearing of the fetus;
• Hypersensitivity to famotidine, as well as other blockers of H2-histamine receptors.

With special care, this medicine is prescribed for liver or kidney failure, immunodeficiency, liver cirrhosis with portosystemic encephalopathy and in childhood.

How to take "Famotidine"?

This medication is prescribed by mouth. Tablets are not chewed, but washed down with a sufficient amount of liquid.

Adults should be treated only by a doctor (depending on the indication).

With the ulcer of the digestive system, especially in the phase of exacerbation, as well as symptomatic ulcers and gastroduodenitis erosive, this medication is recommended to take 20 mg twice a day or once in the amount of 40 mg (at night). If required, the daily dosage of this medication can be adjusted and increased to 80-160 mg.

The duration of treatment with this drug is 6-8 weeks.

To prevent recurrences of ulcers, the drug "Famotidine", the contraindications of which were listed, prescribed 20 mg once a day, at bedtime.

With dyspepsia, which is associated with increased secretory work of the stomach, the drug is recommended to take in the same dosage.

In the presence of reflux-esophagitis, the drug is used twice a day for 20-40 mg for 6-12 weeks.

To prevent aspiration of gastric juice with general anesthesia, the medication is prescribed in the amount of 40 mg in the evening or immediately before the operation.

With Zollinger-Ellison syndrome, the dosage of the drug and the duration of its administration are set individually. Usually the initial dose of the drug is 20 mg. Take this drug every six hours. If required, the amount of the drug can be increased to 160 mg with the same reception frequency.

In the presence of kidney failure (for example, with QC less than 30 ml per minute), the daily dosage of the drug should be reduced to 20 mg.

Method of use in children

What helps "Famotidine" for children? This remedy for babies is prescribed for the same indications as for adults. With a gastrointestinal ulcer in the phase of exacerbation, as well as reflux-esophagitis this medicine is recommended to take as follows: 2 mg per 1 kg of weight per day. This amount of the drug is divided into two doses.

Side Effects

This agent can cause such side effects as:

• Dry mouth, arrhythmia, nausea, acne vulgaris, vomiting;
• Alopecia, abdominal pain, dry skin, flatulence, decreased blood pressure, constipation;
• Skin rash, diarrhea, AV blockade, anorexia, angioedema;
• Hepatitis, itching, increased activity of liver enzymes, anaphylactic shock;
• Acute pancreatitis, manifestations of hypersensitivity, headache;
• Bronchospasm, dizziness, hyperthermia, insomnia, paresis of accommodation;
• Bradycardia, anxiety, confusion, tinnitus, vasculitis;
• Leukopenia, increased fatigue, increased urea levels in the blood, hallucinations, agranulocytosis, drowsiness;
• Thrombocytopenia, depression, hypoplasia, nervousness, pancytopenia, psychosis;
• Aplasia of the bone marrow, blurred vision, hyperprolactinemia;
• Fever, decreased libido, joint pain, gynecomastia, impotence, amenorrhea, muscle pain.

Cost and analogy

The cost of such a drug as "Famotidine" is about 30-55 rubles. If necessary, it can be replaced by analogues such as Gastromax, Kvamatel, Gastrotyd, Ulfamid, Famozol, Famodingexal, Famosan.

Reviews about the drug

The drug "Famotidine" is a very popular antiulcer. Patients claim that it effectively manifests itself in diseases associated with the gastrointestinal tract. Especially often it is prescribed for gastritis and ulcers.

Another advantage of this medicine is its relative cheapness.

As for negative reviews, they very often encounter complaints about side effects of the drug.