Tiotriazolin: instructions for use

Do you know the drug "Tiotriazolin"? Instructions for the use of this medication will be described in detail in the article presented. In addition, we will tell you about the form in which the medicine is on sale, what are the indications, side effects and contraindications.

Composition, packaging and form of the preparation

What is the form of the drug "Tiotriazolin"? The instruction informs that it has several different forms. The most popular are the following:

• A solution intended for intramuscular and intravenous injection. 1 ml of this agent contains 0.025 g of thiotriazoline. Also, the medicament also has ancillary components in the form of water for injection. The drug can be purchased in ampoules of 4 ml (placed in a cardboard package).
• Eye drops "Tiotriazolin". Instructions for the use of this tool states that 5 ml of the drug contains 50 mg of thiotriazoline, as well as other substances. The drug goes on sale in polyethylene bottles-droppers, placed in a cardboard box.
• Tablets "Tiotriazolin." The instruction to this form of the drug states that in one white round tablet with a flat surface contains 100 mg of morpholinium methyltriazolylthioacetate, or the so-called thiotriazoline. As additional components of this drug is potato starch, microcrystalline cellulose, low molecular weight povidone, calcium stearate and sucrose. Typically, in a cardboard box there are 50 tablets.

Pharmacodynamics

What is a remedy like Tiotriazolin? Instructions for use say that this is an antioxidant drug. Its high efficiency is due to antioxidant, anti-ischemic, immunomodulating and membrane-stabilizing properties.

This medicine prevents the death of hepatocytes, promotes their recovery, reduces the degree of fatty infiltration, leads to the normalization of protein, carbohydrate, lipid and pigment metabolism, and also reduces the likelihood of centrolobular necrosis of an organ such as the liver. In addition, this drug improves the isolation and synthesis of bile, normalizes its composition (chemical).

Properties of the medicinal product

What other properties does the preparation "Tiotriazolin" have? Instructions for use of this medicine are required to read. After all, only from it you can find out that the medicine in question lowers the inhibition of oxidative processes in the Krebs cycle, preserving the intracellular ATP fund, and also enhances the activation (compensatory) of anaerobic glycolysis.

It should also be noted that after taking the medicine, the active ingredient begins to activate the antioxidant system, to inhibit the oxidative processes of fats in the ischemic parts of the body. In addition, this drug improves the properties (rheological) of the blood by activating the fibrinolytic system.

Antioxidant properties of the drug are manifested due to the fact that there are sulfur ions in the structure of the tiotrazoline molecule, which are characterized by oxidation and reduction features, as well as tertiary nitrogen, which binds an excessive amount of hydrogen ions.

It should also be noted that the active component of the drug is able to react with lipid radicals and active forms of oxygen. This is due to the pronounced reducing properties of the thiol group. In addition, the medicine prevents the formation of reactive oxygen species, reactivating such anti-radical enzymes as catalase, glutathione peroxidase and superoxide dismutase.

Pharmacokinetics

Is the drug "Tiotriazolin" absorbed? The instruction says that the period of semi-absorption of the drug is 30 minutes, and the bioavailability is 65.5%.

The maximum concentration of the drug in the blood is reached 1.4 hours after admission. The connection with proteins does not exceed 10%.

In large quantities, medicine accumulates in the tissues of the liver, heart, rectum, spleen and kidneys, and minor - in the small intestine and lungs. Tiotriazolin is excreted mainly by the kidneys.

Indications

If there are any abnormalities, tablets, injections and eye drops "Tiotriazolin" can be prescribed? Instructions for the use of these forms contain the following indications:

• cirrhosis of the liver;
• Liver damage toxic, alcoholic, viral and medicinal (for example, after taking antibiotics, antiviral drugs, antituberculosis and antitumor agents, oral contraceptives and tricyclic antidepressants);
• Hepatitis viral chronic;
• Alcoholic hepatitis chronic moderate and minimal activity;
• Fatty liver dystrophy.

Indications for the use of drops:

• Diseases of the cornea;
• Burns or eye trauma;
• Viral conjunctivitis.

Why use the ophthalmologic drug "Tiotriazolin"? The instruction (drops can be bought in any pharmacy) informs that this medication is often prescribed for the prevention of dry eyes, asthenopia and other inflammatory diseases of the visual organs.

Dosage of tablets

How should I use Tiotriazolin tablets? The instruction contains information that the given preparation should be taken only inwards. As a rule, tiotriazolin is prescribed for 1 or 2 tablets four times a day for 25-30 days.

The duration of therapy with this drug should be determined only by the physician individually (depending on the nature of the course and severity of the existing disease).

Medicinal solution "Tiotriazolin": instructions for use

Injections of "Tiotriazolin" are done intramuscularly or intravenously. Their dosage is determined by the doctor (depends on the disease). With myocardial infarction and hepatitis, the drug is injected slowly intravenously 2 ml 2-3 times a day. When cirrhosis medication is administered intramuscularly (2 ml 2-3 times a day). The course of treatment is 60 days.

Eye drops "Tiotriazolin": instructions for use

Drops for eyes "Tiotriazolin" are instilled in the conjunctival sac. Typically, the dosage for adults is 2 drops up to 4 times a day. As for children, the amount of medication is determined only by the pediatrician. Duration of treatment with eye drops should also be established only by the attending physician.

Typically, the duration of therapy with this drug is no more than 2 weeks. But if improvements are not observed, the course can be extended to a month.

In the event that the lesions of the visual organs are extensive and serious, then injections to the eye drops are additionally prescribed (the preparations alternate).

To prevent the drying out of the shells of the eye (while working at the computer), it is necessary to use a medicine for 2 drops during the day with an interval of 2 hours.

Side effects

What side effects can the drug "Tiotriazolin" (injections) cause? The instruction to this tool says that the given medicine is transferred relatively well. However, with the drug in question, undesirable reactions may still occur.

• Central nervous system: dizziness, general weakness, tinnitus.
• The digestive tract: dry mouth, nausea, bloating.
• Vessels and heart: increased blood pressure, tachycardia, arrhythmia, pain in the heart.
• Respiratory system: asthma attacks and shortness of breath.
• Allergies: fever, hypersensitivity reactions, angioedema.
• Local reactions: redness and tingling at the injection site.
• Dermatological reactions: skin hyperemia, itching, hives.

As for eye drops, there were no side effects on their part.

Drug Interactions

According to experts, the drug "Tiotriazolin" can be used in combination with basic medicines intended for the treatment of coronary heart disease. This is due to the fact that said drug is a cardioprotective agent.

It should also be noted that this drug is allowed to be used simultaneously with drugs that are prescribed for the treatment of hepatitis of the corresponding etiology.

Eye drops "Tiotriazolin" can be given to pregnant women, as well as during lactation. Also it should be said that the mentioned form of the drug is allowed to be used simultaneously with other medical devices.

Alcohol and medicine "Tiatriazolin" strengthen each other's action. In this regard, their simultaneous reception is prohibited.

special instructions

The tablets under consideration include sucrose (in the amount of 2.8 mg in one tablet). Thus, the maximum daily dose of the drug may contain about 22.4 mg of the substance. It is necessary to know about this fact in patients with diabetes mellitus.

Methods and periods of storage

Absolutely all forms of the drug "Tiatriazolin" must be stored in a place protected from light and inaccessible to children at a temperature of 14 to 26 degrees. Shelf life of the drug is 3 years.