The medicine "Gliiformin". Instructions for use

The medication "Gliiformin 1000", whose price is about 100 rubles, belongs to the category of hypoglycemic agents for oral administration. The agent slows down gluconeogenesis in the liver, reduces absorption of glucose from the intestine, increases its peripheral utilization, enhances insulin sensitivity in tissues. The drug does not affect the level of LDL and triglycerides, normalizes or lowers weight. The drug has fibrinolytic activity, due to inhibition of the inhibitor of the tissue plasminogen activator. After application, the maximum concentration is observed after 2-2.5 hours. Bioavailability after taking the usual dose is 50-60%. Binding to proteins does not occur. The drug is found in the kidneys, liver, salivary glands. The drug is taken unchanged in the urine.

Appointment

The "Gliiformin" medication is recommended for use in the second type of diabetes mellitus in case of ineffectiveness of dietotherapy and sulfonylureas, with the first type of diabetes the agent is indicated as an addition to insulin treatment.

Contraindications

Glioblastin is not recommended (the instructions for use indicate this) with pathologies of the kidney system, intolerance, disorders of the hepatic function of a pronounced type. Contraindications include conditions complicated by hypoxia (insufficiency of breathing, cardiac activity, cerebral circulation of the acute course, myocardial infarction in the acute phase, anemia). Do not prescribe medicine for infectious lesions, extensive injuries and operations, dehydration, chronic alcoholism. "Gliiformin" medication is not recommended for use with a low calorie diet, lactic acidosis in the anamnesis, during pregnancy, metabolic acidosis (acute or chronic course), lactation, and in studies using radioactive iodine isotopes.

Adverse Reactions

On the basis of treatment, probably the occurrence of anorexia, flatulence, nausea or vomiting, diarrhea, abdominal pain, a taste in the mouth of the metal. As a rule, these undesirable effects are observed at the beginning of therapy. To exclude the development of dyspepsia, you should take the medicine "Gliiformin" (the instruction for use confirms it) while eating. Patients in the course of therapy are likely to have a disorder of the cardiovascular system and hematopoiesis. In particular, anemia (megaloblastic) is noted as a consequence of a violation of absorption of folic acid and vitamin B12. The drug can also provoke hypothermia, myalgia, respiratory disorders, hypoglycemia, hypotension, weakness, dermatitis, drowsiness.

Dosing regimen

Tablets "Gliiformin" take in a dose of 0.5-1 g or 0.85 g once every 10-15 days. In accordance with the level of glycemia, it is possible to increase the amount of the drug. The maintenance dosage is 1.5-2 g. It is not allowed to take more than 3 g per day. To reduce the intensity of undesirable consequences, you should divide the daily dose by 2-3 doses.