The drug "Xylometazoline": instructions for use, description, composition, analogues and reviews

What do you know about the drug Xylometazoline? Instructions for use, the composition of this drug will be described below. From the same article you will learn about how much this medication is worth, whether it is prescribed to children, in what form it is produced, what contraindications and side effects should be known.

Form, description, composition, packaging

You can buy the mentioned facility in the following types:

• 0.05% or 0.1% nasal drops of "Xylometazoline". Instructions for use say that the active component of this drug is xylometazoline hydrochloride. As auxiliary elements sodium hydrophosphate, sodium chloride, potassium dihydrogen phosphate and benzalkonium chloride are used. For sale, a clear, colorless or yellowish nasal solution comes in polymer bottles with a dispenser.
• 0,05% and 0,1% aerosol "Xylometazoline" (spray). Instruction for use reports that the main component of this drug is xylometazoline hydrochloride. In addition, it contains inactive ingredients in the form of disodium edetate dihydrate, sodium hydrophosphate, eucalyptus oil, potassium dihydrogen phosphate, benzalkonium chloride, sodium chloride, sorbitol, macrogol glyceryl hydroxy stearate and glycerol. The drug is packed in polymer bottles with a nebulizer, which are embedded in cardboard packs.
• Gel "Xylometazoline". The instruction for use asserts that this form of the drug also contains an active element in the form of xylometazoline hydrochloride. In addition, the medicament includes the following auxiliary components: glycerol, carbomer, propylene glycol, ammonia solution, propylparaben, ethanol, water and methyl paraben.

Pharmacological properties

What is Xylometazoline? Instructions for use (the price of the medication is listed below) states that it is decongestant, anticongestive and vasoconstrictor. Its active substance is an imidazoline derivative.

The drug is able to stimulate α1- and α2-adrenoreceptors of vessels of the nasopharyngeal mucosa. As a result of this effect, the swelling and hyperemia of the mucosa decreases, and the amount of discharge from the nose decreases.

After using the local remedy, the patient's breathing becomes noticeably easier. This medication is especially often used for allergic conditions, rhinitis and various diseases of the paranasal sinuses.

How does the Xylometazoline spray work? Instruction for use informs that this form of the preparation additionally contains eucalyptus oil. This gives it anti-inflammatory and antibacterial properties. The use of aerosol helps to reduce the swelling of the nasal mucosa.

As a rule, the action of the drug in question is manifested in ¼ hours and lasts about 10 hours.

Pharmacokinetics of the drug

What pharmacokinetic parameters does the drug "Xylometazoline" have? The instruction for use states that these properties have not been studied. With local use of the drug, its absorption is sufficient to develop systemic effects.

Indications

What can be used for this medication? According to the instruction, this tool is prescribed:

• With rhinopharyngitis;
• Rhinitis of various etiologies (viral, allergic, bacterial, traumatic);
• Otitis media and eustachyte.

Also, "Xylometazoline" is used for easy seclusion of the secret with sinusitis and diagnostic procedures in the nasal passages.

Contraindications

Does the local preparation "Xylometazoline" have contraindications? Instructions for use (for children and adults, the drug is applied equally often) reports the following prohibitions:

• Age up to two years;
• Angina pectoris;
• tachycardia;
• hypertonic disease;
• glaucoma;
• Hyperplasia of the prostate;
• Severe atherosclerosis;
• diabetes;
• Thyrotoxicosis;
• Atrophic pharyngitis and chronic rhinitis;
• Hypersensitivity to the drug.

With special care this drug is prescribed during pregnancy. In pediatric practice, the medication is not used in a concentration of 0.1% (up to two years).

Local remedy "Xylometazoline": instruction on the drug

The use of this medication should only be administered intranasally.

0.1% drops in the nose are prescribed to adult patients 2 drops in each nasal pass at a frequency of three times a day.

0.1% spray is used in adults for one push (i.e., 0.1 mg) in each nasal passage. To do this, the applicator is inserted into the nose, but at the same time the vertical position of the container is maintained. The drug is injected thrice a day every eight hours.

0.1% gel is prescribed for adults to 3 drops three times a day.

Due to possible systemic absorption and side effects, all dosages recommended by the doctor should be strictly observed.

Apply any form of medication should not be more than five days. Do not use the drug for a long time with chronic rhinitis.

In the event that there are peels in the nasal cavity, it is better to apply 0.1% gel.

With a missed dose, the subsequent dose should not be doubled.

Adverse events

Does the drug "Xylometazoline" (droplets) cause adverse reactions? Instruction for use asserts that any form of the drug in question can cause the following undesirable effects:

• Sneezing;
• Burning in the throat and nose;
• insomnia;
• Irritation of the mucosa;
• Increased blood pressure;
• Dryness of nasopharyngeal mucosa;
• Vomiting;
• headache;
• Impaired vision;
• dizziness;
• tachycardia;
• Increased excitability;
• Heart rhythm disorder;
• Edema of the nasal mucosa;
• depression.

An overdose of the drug

When using increased doses of medication, the following symptoms may appear in the patient: cyanosis, dilated pupils, vomiting, arrhythmia, nausea, pulmonary edema, fever, respiratory failure, tachycardia, hypertension, cardiac arrest and mental disorders.

Such signs as drowsiness, coma, bradycardia and apnea, suggest the suppression of the CNS.

As a treatment for such conditions, gastric lavage, artificial respiration, sorbents and drugs for lowering blood pressure, as well as anticonvulsant and antipyretic agents are performed.

Drug Interactions

The drugs that excite the sympathetic system can enhance the effect of Xylometazoline.

This medication can not be combined with antidepressants and MAO inhibitors, since their interaction contributes to the emergence of hypertensive crisis.

Analogues and price

How much does the local preparation "Xylometazoline" cost? Buy this tool in drops you can for 68-75 rubles, and in the form of gel and spray - for 53-63 rubles.

As for the analogues, the most common ones include the following medicines: Merialis, Pharmazoline, Tizin Xylo, Pharmazoline N, Otryvin with menthol and eucalyptus, Galazolin, Otryvin, Xylo-mefa ".

Reviews about the drug

Reviews of the local "Xylometazoline" are more positive. Patients note the effectiveness and duration of this medication.

According to reviews, the drug in the form of drops to dose is rather difficult, since part of the solution inevitably enters the pharynx, which contributes to the occurrence of side effects. Therefore, most patients prefer to use a dosed spray.

Many people note the following undesirable reactions after using the drug: neurosis, insomnia and anxious arousal.

Also, some patients talk about ricochet stagnation, called medical rhinitis. Prolonged use of the drug contributes to the narrowing of the vessels, which is replaced by the resumption of discharge and increased blood flow. The nasal congestion also returns.

With prolonged use of the drug, atrophy of the nasal mucosa develops. To avoid such phenomena, you should limit the use of the drug to 3 days.