The drug "Cefotaxime": reviews and instructions for use

The drug "Cefotaxime" refers to the third generation of cephalosporinic semi-synthetic antibiotics, has a wide spectrum of action, destroying gram-negative and gram-positive bacteria.

Pharmacokinetic and pharmacodynamics of the drug "Cefotaxime"

Reviews of pharmacists indicate the ability of the drug to resist pathogens (bactericidal effect). It is able to neutralize strains that show resistance to penicillins, aminoglycosides and sulfonamides. When using the agent, the activity of the enzyme transpeptidase is inhibited, peptidoglycan is blocked and the synthesis of cells of pathogenic pathogens is disrupted. In comparison with the cephalosporins of earlier generations, the drug "Cefotaxime" shows less activity with respect to Gram-negative cocci.

The greatest concentration of the drug in the blood when injected into the muscle is observed after half an hour, with intravenous injection - for five minutes. The bactericidal action of the antibiotic is maintained up to half a day, which necessitates the use of the drug twice a day.

Indications for taking the drug "Cefotaxime"

The doctors' recommendations recommend the use of a medicine for the treatment of infections of the bronchopulmonary system: pleurisy, pulmonary abscesses, pneumonia. Antibiotic prescribe for the treatment of angina, sinusitis, otitis. With the help of medication, urinary tract infections are eliminated, it is used in endocarditis, bacterial meningitis, septicemia. The drug is effective for gynecological pathologies that are infectious in nature (gonorrhea, chlamydia), with Lyme disease and dermatitis.

Contraindications to taking the drug "Cefotaxime"

Reviews of therapists and instructions for use prohibit the use of the drug in patients with hypersensitivity to cephalosporin group drugs, allergic to penicillins. Incompatible treatment during pregnancy, with bleeding, with acute and chronic enterocolitis. Contraindications include liver and kidney failure.

Side effects of the drug "Cefotaxime"

Patients' testimonies indicate negative manifestations when using an antibiotic. Most often in the treatment there are local reactions in the field of drug administration. Possible skin rashes, itching, pain, hyperemia, phlebitis. After long-term therapy, symptoms of pseudomembranous colitis are observed .

Laboratory blood tests in some cases show thrombocytopenia, eosinophilia, leukopenia, neutropenia. In addition, the amount of urea, alkaline phosphatase and serum enzymes (AST, ALT) can increase.

Rarely, side effects occur in the form of encephalopathy or anaphylactic shock.

Precautions for using the drug "Cefotaxime"

Reviews and instructions indicate the inadmissibility of self-treatment, before using the medication should always consult a doctor. It must be remembered that in the presence of allergic reactions to the action of other drugs in the past, the antibiotic is used after additional studies. With caution appoint the drug "Cefotaxime" for children: reviews of pediatricians indicate that children under 2.5 years can only do intravenous injections.

After treatment, which lasted more than ten days, it is necessary to monitor the condition of peripheral blood. Pregnant and lactating women are prescribed medication only in case of emergency.

Incompatible drug "Cefotaxime" and alcohol. There may be congestion of the face, tachycardia, vomiting, cramping from the stomach area, lowering the pressure.