The analogue of "Diflucan" is the drug "Fluconazole"

The analogue of "Diflucan" - means "Fluconazole" - is an antifungal drug with a highly specific effect. The drug is able to block the activity of a number of enzymes, prevent the conversion into ergosterol lanosterol. In addition, the drug increases the permeability of cell membranes, prevents replication and growth of pathogens. The drug is effective in opportunistic mycoses caused by fungi of the genus Candida, including generalized types of candidiasis on the basis of immunodepression. When taken orally, the drug is good absorbability. Absorption rate does not affect food intake. Bioavailability of the drug is about 90%. The maximum content of blood in the blood reaches 30-90 minutes. The drug is well distributed to tissues and liquids, penetrates into the milk. It should be said that the price of the drug "Fluconazole" is much lower than the cost of "Diflucan" (the last will have to pay from four hundred to eight hundred rubles).

Indications

The drug "Fluconazole" (analogous to "Diflucan") is prescribed for cryptococcal meningitis, cryptococcosis and other localizations of cryptococcal infection in patients with normal immune response and with different types of immunodepression. Indications include candidiasis generalized type, disseminated candidiasis, candidemia, other types of invasive infections, the causative agent of which is the fungus of the genus Candida. The drug is recommended for the prevention of fungal lesions in patients with malignant tumors. Appoints a remedy for mycosis of the feet, groin, trunk.

Dosing regimen

The analogue of "Diflucan" - a drug "Fluconazole" - is prescribed to patients from the age of fifteen with a mass of more than 50 kg. With cryptococcal infections of different locations in the first day at a dose of 400 mg. Subsequently, the amount of medication is reduced to 200 mg per day. The duration of therapy for these pathologies depends on the effectiveness of treatment, which is confirmed by the results of mycological examinations. The use of cryptococcal meningitis should last no less than six to eight weeks. With disseminated candidiasis, candidemia and other candidiasis infections of invasive type on the first day, the amount of the drug is 400 mg, then the dose is reduced to 200 mg. In case of insufficient effectiveness of treatment, the dosage is increased back to 400 mg. The duration of treatment depends on the effectiveness of the remedy.

Side effect

Analog "Diflucan" - the drug "Fluconazole" - can cause dizziness, pain in the head, abdomen, abdominal pain, deterioration of appetite, nausea. On the basis of treatment may develop thrombocytopenia, an allergic reaction in the form of edema of the face, epidermal toxic necrolysis, skin itching. Analogues of tablets can cause a violation of liver, kidney, hypokalemia, hypertriglyceridemia.

Contraindications

Do not prescribe a drug before the age of 4, with intolerance of its components. Contraindicated combined use with the drug "Terfenadin", "Astemizol" and others, contributing to the elongation of the QT-interval. Caution in the period of therapy is manifested with a predisposition to various pathologies (to the violation of electrolyte balance, organic heart diseases and others).