"Metamax" in ampoules: instructions for use. Reviews, prices, analogues

What is the use of the drug "Methamax" in ampoules? Instructions for use and indications for receiving this remedy will be described in the materials of this article. From it you will also learn about what other form of release this medicine has, what is included in its composition, how to use it correctly and how much it costs.

Packaging, composition, form and description

What substances does the "Methamax" preparation contain in ampoules? The instruction for use states that a clear, mildly odoriferous solution for injection includes an active component such as 3- (2,2,2-trimethylhydrazinium) propionate dihydrate. Also, the medicament contains an auxiliary substance in the form of purified water.

In what packaging is the "Methamax" drug sold in ampoules? The instructions for use indicate that this 5ml preparation is placed in contour packs, which, in turn, are in packs of cardboard (10 ampoules each).

It should also be noted that this means has another form of release. White capsules "Methamax", the price of which is quite high, contain the same active substance as the injection solution. As for the auxiliary components, they include potato starch, anhydrous colloidal silicon dioxide and magnesium stearate.

The medicine is sold in contour packs (10 capsules), which are in cardboard packs.

Pharmacological properties

Description of the drug "Metamax" contains information that it has an angioprotective effect. This medication is a synthetic analogue of butyrobetaine, which inhibits the enzyme hydroxylase.

The drug under consideration is capable of lowering the synthesis of carnitine, as well as reducing the accumulation in the tissues and cells of the derivatives of acylcarnitine and acylcoenzyme A.

It should also be said that this agent improves the transport of ATP, activates glycolysis, restores the balance between transport and oxygen consumption in cells located in ischemic zones.

Pharmacodynamic and pharmacokinetic characteristics

What are the properties of the drug "Methamax" in ampoules? Instruction for use indicates that due to its features this drug has a broad pharmacological effect. It activates humoral and tissue immunity, reduces the severity of signs of physical and mental stress, has cardioprotective properties, increases the capacity for work and the intensity of metabolic processes.

If a patient develops acute ischemic tissue damage, then the medicine "Metamax" reduces the size of the necrotic zone and shortens the rehabilitation period. In chronic and acute disorders of cerebral circulation of ischemic nature, the drug promotes redistribution of blood flow in the zones of ischemia.

In people who have heart failure of a chronic nature, exercise tolerance increases, and the contractility of the myocardium increases.

With regard to patients with chronic alcoholism, then with this diagnosis, the drug in question can eliminate disturbances in the work of the nervous and somatic systems, and with dystrophic and vascular diseases of the fundus, improve local blood circulation.

After intravenous administration of the solution, its highest concentration in the blood is observed for ¼ hour. The elimination half-life is 2-4 hours and depends on the dosage. With prolonged use of the drug, its half-life may increase.

If the patient was prescribed an oral form of the drug, then the drug is very quickly absorbed from the digestive system. After 1-2 hours in the blood, the maximum concentration of the drug is observed. At the same time, its bioavailability is 78%. The half-life of this form is 3-6 hours.

The drug is excreted from the human body mainly through the kidneys.

Indications for use

The administration of medicinal products "Methamax" (ampoules and capsules) is carried out only by the attending physician. As a rule, such a remedy is used to treat such pathologies as:

• Diseases of the vessels of the fundus, dystrophy of the retina ;
• Chronic bronchitis, chronic obstructive pulmonary disease;
• Ischemic circulatory disorders in the brain;
• Allergic and infectious bronchial asthma;
• Chronic alcoholism (for relief of abstinence syndrome);
• Reduced physical performance, including those involved in sports;
• encephalopathy;
• Cerebrovascular insufficiency.

It should also be noted that the drug "Metamax", the price of which will be listed below, is often used to shorten the length of the rehabilitation period after surgical interventions.

Contraindications for use

What are the contraindications to the use of the medication "Metamax"? Ampoules and capsules can not be used for:

• Breastfeeding and pregnancy;
• Increased intracranial pressure, violation of outflow in veins, intracranial tumors, as well as organic lesions of the central nervous system;
• Hypersensitivity to drug substances;
• Childhood.

Method of application in ampoules

Dosing solution for injection should be selected only by the attending physician (depends on the type of disease). As a rule, injections are done in the morning.

With cardiovascular disease, patients are injected daily with 5-10 ml of 10% of the agent for 4-6 weeks.

With circulatory disorders in the brain (in the acute phase), the drug is prescribed once a day in a volume of 5 ml.

With dystrophic abnormalities and vascular pathology of the retina, medication is administered parabulbar and subconjunctival every day in an amount of 0.5 ml for 10 days.

In chronic alcoholism, the drug is administered intravenously or intramuscularly twice a day for 2 ampoules for 8-10 days.

How do I take capsules?

The way of application and dosage of capsules "Metamax" should also be determined by specialists. This form of medication is taken early in the morning, as the patient can develop a stimulating effect. With mental and physical exertion appoint 250 mg of the drug four times a day. In vascular diseases of the eyes and dystrophic retinal deviations, the injection form of the drug is used first (first 10 days), and then they switch to oral capsules (0.5-1 g once daily). The total duration of therapy is 5-6 weeks.

With chronic violations of the blood circulation of the brain take 500 mg of medicament per day. Duration of treatment is 5-6 weeks.

When heart diseases are prescribed, 0.5-1 g of the drug once a day. Duration of treatment is 5-6 weeks.

Adverse Reactions

Description of medicines "Metamax" (capsules and injections) contains information that they can cause the following side effects:

• Respiratory system: shortness of breath and dry cough.
• Central nervous system: agitation, headache, tremor, paresthesia, dizziness, psychomotor disorders.
• The digestive tract: dryness or hypersalivation in the oral cavity, diarrhea, dyspeptic phenomena, nausea, metallic taste in the mouth, abdominal pain, vomiting.
• Hemopoietic system: eosinophilia.
• Heart and blood vessels: changes in blood pressure, tachycardia, arrhythmia.
• General reactions at the injection site: hyperemia and pain.
• Allergy: anaphylactic shock, rash, angioedema, hives, redness of the skin and itching.
• Other: hyperthermia, increased sweating, pain in the chest, weakness, chills.

Overdose

Until now, there have been no known cases of overdose by this remedy. However, experts argue that when using high doses of medication, the patient may experience symptoms that are very similar to side effects.

To treat such conditions, gastric lavage is performed, and also a cleansing enema is used or a salt laxative is drunk.

Drug Interactions

Joint use of the drug with cardiac glycosides, hypotensive and antianginal agents intensifies the effect of the latter.

Medication "Metamax" can be combined with diuretic and antiarrhythmic drugs, as well as with anticoagulants and antiaggregants.

You should be extremely careful when using this drug at the same time with peripheral vasodilators, beta-blockers, "Nifedipine" and "Nitroglycerin." This is due to the fact that against the background of this combination the patient can develop a moderate tachycardia or arterial hypotension.

Analogues of the drug, reviews and prices in pharmacies

What can replace such a medical product as "Metamax"? The following medicines are analogues of this remedy: "Vasonat", "Trimedronate", "Vazopro", "Celebis", "Metonat", "Milkardil" and "Mildronate".

It should be mentioned that all these medicines have their own characteristics, side reactions and contraindications. In this regard, before using them, it is necessary to visit a doctor.

How much does the drug in question cost? The prices in pharmacies for this remedy may be different and depend on the mark-up, as well as on the output form. On average, for medicinal capsules you will have to give about 380 Russian rubles (for 40 pieces). As for ampoules, they are slightly more expensive. Their cost is about 500 rubles (10 ampoules). This difference in price doctors explain the effectiveness of funds. Indeed, patients' reviews say that Methamax injectable solution copes with the task better than the oral form of the drug. This is due to the fact that after intravenous administration the absorption of the drug occurs much faster and in a larger volume.