Lopedium tablets: instructions for use, reviews

"Losedium" is a drug that depresses peristalsis. It is gelatin capsules with a hard shell, painted in gray or dark green color (they contain a homogeneous powder of whitish color) or white tablets.

Pharmacological properties

Tablets "Losedium" (instructions for use given in this article) consist of a substance that is able to communicate with opiate receptors of the intestine. Due to this connection, the release of acetylcholine and prostaglandins is suppressed. In this way the pulse peristalsis is reduced and the time interval of food passage through the digestive tract is significantly increased. Also, the walls of the intestine absorb more fluid, they come into muscle tone of the sphincter.

Pharmacokinetics

Most of the loperamide, which has entered the body, is absorbed in the intestine, however, due to the intensive metabolism of the first passage, the systemic bioavailability is only a quarter of a percent.

Due to the research it was found out that the drug is distributed relative to the intestinal wall, and at the same time it binds to the receptors of the longitudinal layer of the muscle shell. For the most part, loperamide binds to proteins, especially albumin.

Tablets "Losedium" (instructions for use refer to them as safe preparations) are almost completely absorbed by the liver, where they are metabolized, conjugated and excreted from the body with bile. Due to the very intense effect of the first passage of the drug through the liver, the concentration of the drug itself in the blood decreases significantly, remaining very low. The drug is completely eliminated from the body after eleven or fourteen hours.

Indications for use

"Lediumum" (pills) instruction for use recommends taking in case of chronic and acute diarrhea. This drug can be taken by people involved in travel ("diarrhea of a tourist"). In this case, the course of treatment should be two days. However, if blood is found in the bowel movement, do not use the medication until the cause of the doctor's indisposition is established.

Contraindications

Do not use the pill in the event that there is an increased sensitivity to loperamide hydrochloride or any other components of the drug.

The main contraindications for patients:

- bacterial enterocolitis, obtained as a result of the activity of certain microorganisms:

- acute dysentery, accompanied by bloody diarrhea and fever.

Combine the drug with any antibiotics with extreme caution. Be sure to tell the doctor about this.

Do not use Lodeium tablets (instructions for use warn patients) when developing constipation, bloating, or intestinal obstruction. Avoid means in case you need to avoid oppression of peristalsis.

How to take Lodepin in tablets

The drug can be used by adults and children over six years old. A capsule (tablet) should be swallowed whole, washed down with a small amount of pure water.

For chronic and acute diarrhea, the dose for adults should be 4 mg of the drug (two pcs.). For children, one thing will be enough. The drug should be taken after each liquid bowel movement. The maximum daily allowance for children and adults is six to eight tablets.

If the symptoms of acute diarrhea do not disappear within forty-eight hours, the drug should be discontinued.

Patients of advanced age do not need a special adjustment of the dosage of capsules. The same goes for people who suffer from kidney problems. "Lediumum" (pills) instruction for children 3 years of age is not recommended.

Application Features

Usually, the treatment of diarrhea is systematic. If the patient has the opportunity to determine the etymology of the disease, then in this case it is necessary to carry out specific treatment. It is possible that this drug is prescribed by doctors during the application of antibiotic therapy. In parallel with taking the "Lediumum" (pills) medication, the instruction for children recommends substitution therapy for the replenishment of electrolytes and liquid. This should be done in the event that there is an imbalance and dehydration of electrolytes.

Patients who have acquired immunodeficiency syndrome (AIDS), with diarrhea, immediately stop taking "Lopei" in case of bloating.

"Losedium" (tablets): instructions for use in pregnancy and lactation

Doctors do not recommend taking the drug to pregnant and lactating women. This is due to the fact that a small amount of loperamide can enter the breast milk. That is why women "in the situation" should always consult a doctor before buying the drug.

Interaction with other drugs

Scientists know cases of interaction with drugs that have similar pharmacological features. Medicines that have a depressing effect on the central nervous system can not be combined with the "Lopezium."

It is worth considering that loperamide is a substrate of P-glycoprotein. The simultaneous use of "Lopezium", as well as quinidine and ritonavir, can lead to a significant increase in the concentration of the drug in the blood. The dose may increase two to three times. A similar effect is observed with the use of itraconazole and ketaconazole.

It was found that drugs that have similar pharmacological properties can increase the effect of loperamide several times. But the drugs that accelerate the process of passing the contents of the gastrointestinal tract, on the contrary, reduce its effectiveness.

Overdose

Lopedium tablets (instructions for use describe the symptoms of an overdose) can lead to loss of coordination, headache, drowsiness, stupor and delay in urination. If you find these symptoms, you can take Naloxone. In rare cases, wash the stomach and drink activated charcoal.

Adverse Reactions

On the skin can form rashes, including Stevenson-Johnson syndrome; Erythema multiforme; Edema; Itching and hives.

The drug can negatively affect the nervous system. Patients may experience drowsiness, impaired coordination, loss of consciousness, hypertension and tremor.

On the part of the digestive system, patients may notice dry mouth, constipation, nausea, flatulence, vomiting, intestinal obstruction. Many patients experienced rapid fatigue.

With special care is to apply the drug to car drivers and working with mechanisms, since the drug can lead to drowsiness.

Form of release, packaging and composition

Each capsule (tablet) contains two milligrams of loperamide hydrochloride. In addition to the basic drug substance, the preparation also contains auxiliary, namely: talc, magnesium stearate, corn starch and lactose monohydrate.

For sale tablets in plates of ten pieces. In the package can be from one to five blisters.

The tablets are white in color and round in shape, convex on one side.

The drug should be stored in a dark, dry place out of the reach of children. The temperature should not exceed twenty-five degrees. Shelf life - five years from the date of manufacture. The drug can be bought at any pharmacy without a doctor's prescription. However, do not forget that self-medication can lead to negative consequences.