The drug 'Tamoxifen'. Instruction, indications

The drug "Vero-Tamoxifen" has been used for a long time. This drug belongs to the category of selective estrogen receptor modulators. The medicine, falling into the bloodstream, is distributed throughout the body.

Due to the fact that the drug "Tamoxifen" has a slight estrogenic activity, it has a very weak stimulating effect on cells. Possessing the ability to block free receptors on the surface of tumor cells, the drug inhibits the stimulation of hormones by neoplasms. Thus, the antiestrogenic effect of the drug is manifested.

The drug "Tamoxifen" instruction characterizes as a means of choice in neoplasm in the mammary gland in women in premenopausal. The medicine is prescribed and in postmenopause. However, during this period, the medication is less effective than the inhibitors (depressant action) of aromatase (a special enzyme).

The drug "Tamoxifen" instruction recommends for prostate and breast cancer in men, skin cancer, breast cancer, ovaries in women. The medicine is prescribed for female infertility. The drug "Tamoxifen - Hexal" is additionally shown as an auxiliary agent after performing surgical treatment with breast carcinoma.

Medication can also be used as a prophylaxis. Thus, the drug "Tamoxifen" is able to block the receptors of estrogens in healthy breast cells. This allows prescribing the drug to patients with a high predisposition to develop cancer, but not previously affected.

As a rule, the duration of the medication "Tamoxifen" - five years. It should be noted that in the case of the appointment of the drug in the metastatic development of a cancerous tumor, it is taken as long as its effect continues.

Dosage of the drug "Tamoxifen" instruction recommends setting individually. Usually they are prescribed twenty to forty milligrams a day.

The drug "Tamoxifen" instruction does not admit to admission during pregnancy.

The use of a medicine can provoke a number of undesirable consequences. In particular, the drug causes depression, dizziness, visual disturbance, inflammation of the veins. In some cases, there may be headache, bleeding (vaginal), genital itching, rash. The most common side effects include nausea, fever, pain in lesions and bones.

It should be noted that over time, the effectiveness of the drug "Tamoxifen" is weakening. As a result, the medicine is not able to exert the previous influence on the cells. In some cases, its effect becomes inverse. In other words, the medication begins to act as an estrogen and stimulate the development of cells, instead of suppressing them. To a greater extent, this effect is associated with the ability of estrogen receptors to change their size, density, shape or even function. In addition, the cancer in the mammary gland can be accompanied by the presence of both hormone-negative and hormone-positive cells. In this case, the drug "Tamoxifen" in relation to one cell is effective, and in relation to others - no. Thus, some receptors react, while others show resistance to the drug.

If the patient takes medication during the postmenopausal period and after two or three years becomes ineffective, the doctor usually takes the woman to aromatase inhibitors.

It should be noted that one form of therapy (for example, hormonal drugs) is not able to replace other methods of treatment. It should be borne in mind that often the value of each method of exposure is significantly increased in a complex application.

Throughout the treatment using the drug "Tkamoksifen" should monitor the blood picture systematically.